Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role Due to Low ExpressionArticle Published on 2024-07-012024-09-05 Journal: Cells [Category] update2024, [키워드] acetylpolyamine oxidase Doxorubicin polyamines spermidine spermine virus replication [DOI] 10.3390/cells13131134 PMC 바로가기 [Article Type] Article
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetesArticle Published on 2023-11-012024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] β cell Disease modification islet ornithine decarboxylase polyamines prevention Trial Type 1 diabetes α-difluoromethylornithine β cell stress [DOI] 10.1016/j.xcrm.2023.101261 PMC 바로가기 [Article Type] Article
Gut Microbial Metabolites on Host Immune Responses in Health and DiseaseReview Article Published on 2023-02-242024-09-05 Journal: Immunology [Category] update2024, [키워드] bile acids immunomodulation microbiota polyamines Short-chain fatty acid [DOI] 10.4110/in.2023.23.e6 PMC 바로가기 [Article Type] Review Article
The capture of host cell’s resources: The role of heat shock proteins and polyamines in SARS-COV-2 (COVID-19) pathway to viral infectionReview Published on 2022-04-192023-07-08 Journal: Biomolecular concepts [Category] COVID19(2023년), [키워드] drug targets heat shock proteins human hosts polyamines SARS-CoV-2 [DOI] 10.1515/bmc-2022-0008 [Article Type] Review
Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients순환 아세틸 화 된 폴리아민Research Paper Published on 2021-09-152022-09-01 Journal: Aging (Albany NY) [Category] 진단, [키워드] acetyl transferase acetylated aggregate anthranilic acid bacterial metabolites baseline Cancer cancer patient Cancer patients cardiovascular disease characterized COVID-19 COVID-19 diagnosis COVID-19 severity Cytokines Depletion described Diagnosis elevated Elevation enrolled exhibiting General population Hospitalization immunosuppressive increase in indicate indole Inflammatory cytokines Kynurenine malignant disease metabolite metabolome metabolomic signature metabolomics microbiota Mild mild or severe Covid-19 MOST neurodegeneration overactivation Patient patients Patients with cancer polyamine polyamines poor prognosis positively correlated prolonged viral shedding SAT1 serum severe COVID-19 severity spermidine spermine Support susceptible Trial Tryptophan uninfected Viral [DOI] 10.18632/aging.203525 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antiviralsSARS-CoV-2 매개 대사 및 자가포식 조절 장애, 숙주 표적 항바이러스제 밝혀Article Published on 2021-06-212022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, 치료제, [키워드] accumulate accumulation Activation administration AKT1 AMPK Antiviral ATG14 Autoimmune response autophagic pathway autophagic pathways autophagy autophagy marker autophagy markers BECN1 Cell cell type cellular metabolism Compound COVID-19 COVID-19 patients disease dysregulation Host host cell human lung cell identify immune gene immune genes in vitro infected cells Infection Inflammatory inhibit SARS-CoV-2 inhibitor intestinal organoid Intestinal Organoids limit lung Macroautophagy membrane metabolism metabolites MK-2206 modulate mucosal niclosamide oligomers pathway polyamines Protein reduce reduction responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells selective Sequencing single-cell Skp2 spermidine spermine Support targeting transcriptional regulation Treatment TSC2 Ulk1 virus inhibition [DOI] 10.1038/s41467-021-24007-w PMC 바로가기 [Article Type] Article
Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry표적 폴리아민은 세포 부착 및 진입을 감소시켜 코로나바이러스 감염을 억제합니다Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antivirals attachment bat bats binding biosynthetic biosynthetic pathway cells China coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication Coronaviruses COVID19 Critical Depletion disease drug target Endemic Epidemic evaluate facilitate human cells human populations humans in vitro infect Infection limitation MERS MERS-CoV metabolite Middle East Middle East respiratory syndrome Coronavirus outbreak Outbreaks pathway polyamine polyamines reduce reduced replication mechanism respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spread targeting treat widespread [DOI] 10.1021/acsinfecdis.0c00491 PMC 바로가기 [Article Type] Article
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkersCOVID-19 환자의 대사체 분석은 단계 의존적 및 예후 바이오마커를 밝힙니다.Clinical Trial Published on 2021-03-112022-08-13 Journal: Cell Death & Disease [Category] SARS, 바이오마커, 임상, 진단, [키워드] alteration amino acids Analysis anthranilic acid circulating metabolome cohort of patient COVID-19 COVID-19 patient COVID-19 patients Critical Critical disease derivatives disease Diseases Elevation Evolution Hospitalization immunosuppressive properties individual Indoleamine 2,3-dioxygenase inhibit intensive care intensive care unit interleukin-10 interleukin-10 and -18 Kynurenine Kynurenine pathway lipids maintenance metabolite metabolome metabolomics Mild mild COVID-19 patients moderate moderate disease organism oxygen Oxygen therapy oxygen therapy) pathogenic challenges pathway physiological state plasma plasma metabolome Pneumonitis polyamines prognostic biomarker Prognostic value provide rate-limiting enzyme rate-limiting enzymes required single metabolite sugars therapeutic utility Tocilizumab transfer Tryptophan tryptophan 2,3-dioxygenase viral infection [DOI] 10.1038/s41419-021-03540-y PMC 바로가기 [Article Type] Clinical Trial
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines박테리아의 DNA 슈퍼코일링 차이는 폴리아민에 의한 이질적인 DNA 자이라제 활성화로 인해 발생합니다.Research Article Published on 2020-10-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation activity addition Alter Amino acid Bacteria bacterial species bacterial specy change changes in Concentration conserved Control determine discrepancies discrepancy disparate DNA DNA supercoiling E . coli enzyme Enzymes Escherichia coli Extracellular gyrase humans identify identity in vivo inhibit living cell mechanism metabolic conditions metabolic pathway metabolic pathways organism pathogen Pathogens pathway physiological polyamine polyamines precursor putrescine reducing reflect regulate regulated responsible Salmonella Signal transduction spermidine target topoisomerase [DOI] 10.1371/journal.pgen.1009085 PMC 바로가기 [Article Type] Research Article
Ornithine Decarboxylase Inhibition: A Strategy to Combat Various Diseasesarticle Published on 2018-12-312024-09-01 Journal: Mini-Reviews in Medicinal Chemistry [Category] 말라리아, [키워드] African sleeping sickness antibiotic Cancer malaria ornithine decarboxylase polyamines [Article Type] article