COVID-19 vaccine associated transverse myelitis-Evusheld as an option when vaccination is not recommended due to severe adverse eventsCOVID-19 백신 관련 횡단 척수염-심각한 부작용으로 인해 백신 접종이 권장되지 않는 경우 옵션으로 EvusheldArticle Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administer administration adverse event Adverse reaction antibody Autoimmune COVID-19 COVID-19 vaccine determine individual Inflammation mechanism MHRA Moderna mRNA vaccine monoclonal antibody Patient precluded prophylactic therapy PROTECT receiving resulting Safe SARS-COV-2 infection severe adverse event spike-protein therapy U.S. FDA vaccination [DOI] 10.1080/21645515.2022.2068338 PMC 바로가기 [Article Type] Article
Limited Correlation between SARS-CoV-2 Serologic Assays for Identification of High-Titer COVID-19 Convalescent Plasma Using FDA ThresholdsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody assay standardization assays authorization can be used CCP clinical trials Clinical use Cohort collected comparable Concordance consequence convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma criteria Cutoff cutoff value Donor drug Emergency Emergency use authorization EUA Expanded Access Program FDA FDA EUA FIVE food high-titer CCP high-titer convalescent plasma highlight hospitalized patients identification identify immunosuppressed patients indicate Limited lowest monoclonal antibody multiple serological assay Pandemics Pathogens positive precluded provided ranged reduce released Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serologic serologic assay serological Serological assay serological assays serology serum sample significantly Standardization therapeutic therapeutic option therapy threshold Treatment [DOI] 10.1128/spectrum.01154-22 PMC 바로가기
Hydroxychloroquine versus placebo in the treatment of non-hospitalised patients with COVID-19 (COPE – Coalition V): A double-blind, multicentre, randomised, controlled trialResearch article Published on 2022-07-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 신약개발, 임상, 치료법, [키워드] 1:1 Analysis benefit Brazil Chloroquine Clinical deterioration Coalition complement conducted Controlled trial COPE COVID-19 COVID-19 patient did not reduce double-blind Enrollment events finding form funding hospitalisation Hydroxychloroquine Infection intention-to-treat ITT matching placebo Meta-analysis Mild mITT analysis moderate molecular multicenter multicentre no significant difference non-hospitalised Outpatient participants with SARS-CoV-2 Patient patients with COVID-19 Placebo placebo group positive precluded presenting Primary outcome randomised Randomly RCT receive reducing Registered risk risk factor serology testing Seven Statistical power suggested Support Symptom Treatment treatment allocation Trial use of hydroxychloroquine was performed [DOI] 10.1016/j.lana.2022.100243 [Article Type] Research article
Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare workers: a multicentre, parallel-group randomised controlled trial from IndiaRandomized Controlled Trial Published on 2022-06-012022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 1:1 95% CI addition adverse event age ARMS assigned clinical pharmacology control arm COVID-19 COVID-19 infection Definitive determine female healthcare healthcare worker heterogeneity hospital Hydroxychloroquine hydroxychloroquine group India intervention arm laboratory-confirmed multicentre no significant difference Open-label parallel-group participant Personal protective equipment precluded primary analysis proportion public health randomisation randomised randomised controlled trial Randomised trial reduce screened Secondary outcomes Serious Adverse Event the primary endpoint Treatment Trial [DOI] 10.1136/bmjopen-2021-059540 PMC 바로가기 [Article Type] Randomized Controlled Trial
Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patientsClinical Trial Published on 2022-03-082022-10-04 Journal: Blood advances [Category] SARS, 임상, [키워드] Allogeneic Analysis antibody Antibody concentrations Antigen autologous benefit binding antibody unit Cell cell transplantation Chemotherapy chimeric antigen receptor CLL Concentration COVID-19 vaccination disease HCT hematological hematology high risk High-dose identify IgG IgG4 Immunocompromised Immunoglobulin Immunosuppressant in healthy individuals leukemia lymphoma mRNA-1273 Multiple myeloma myeloid malignancies Netherland Obtaining Patient patients patients treated precluded predicted quantified recipient Registered response S1 IgG serum severe COVID-19 subunit T-cell therapy Treatment Trial vaccination Virus neutralization [DOI] 10.1182/bloodadvances.2021006917 PMC 바로가기 [Article Type] Clinical Trial
Unusual SARS-CoV-2 intrahost diversity reveals lineage superinfection특이한 SARS-CoV-2 숙주 내 다양성이 혈통 중복 감염을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: Microbial Genomics [Category] SARS, 변종, 치료기술, [키워드] abundance acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach characterized codetection Coinfection coronavirus 2 COVID-19 COVID-19 disease dataset defined detect difficulty distribution epidemiological data Factor Genomics Infection infections investigated Lineage Mutation mutations nine number of sample pandemic phenotype phylogenetically precluded profiles progression provide raw sequencing data Recombination representing respiratory reveal SARS-CoV-2 SARS-CoV-2 lineage sequenced Sequencing sequencing data Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Variability viral lineage viral lineages viral recombination window [DOI] 10.1099/mgen.0.000751 PMC 바로가기 [Article Type] Article
Transformation to telephonic genetic counselling during SARS-CoV-2 pandemic: challenges and suggested protocol in Indian scenarioSARS-CoV-2 대유행 중 전화 유전 상담으로의 전환: 인도 시나리오의 과제 및 제안 프로토콜Article Published on 2022-01-012022-09-11 Journal: Journal of genetics [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities COVID-19 COVID-19 pandemic diagnosed gcs Genetic genetic counselling lack lockdown Mumbai offered Patient physical platform precluded protocol public transport recommendation restriction retrospective retrospective data SARS-CoV-2 social distancing suggested their family member their family members transformation Transport wake [DOI] 10.1007/s12041-022-01370-1 PMC 바로가기 [Article Type] Article
Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suraminSARS-CoV-2 RNA 의존성 RNA 중합효소와의 약물 상호작용 연구를 위한 표면 플라즈몬 공명 접근법, 수라민의 치료 가능성 강조Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료제, [키워드] approach binding ChIP drug drug target Favipiravir highlight Interaction precluded RdRP real time ribavirin RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA sofosbuvir study drug Suramin surface plasmon surface plasmon resonance Treatment virus replication [DOI] 10.1016/j.jviromet.2021.114283 PMC 바로가기 [Article Type] Article
The effect of eye protection on SARS-CoV-2 transmission: a systematic reviewSARS-COV-2 전송에 대한 눈 보호 효과 : 체계적인 검토Research Published on 2021-11-042022-09-10 Journal: Antimicrobial Resistance and Infection Control [Category] MERS, SARS, 변종, [키워드] 95% CI adjusted article CENTRAL certainty certainty of evidence changes in clinical trial clinical trials Cochrane Library Community comparative observational study confounder country COVID-19 current determine Effectiveness Europe explained Eye protection Face shield glasses Goggles healthcare Healthcare workers heterogeneity India Infection prevention infection with SARS-CoV-2 Meta-analysis observational studies observational study Odds ratio Odds ratios PMC populations precluded Prevent Protective behaviours reduction Relative risk remains uncertain reported Research Result retrospective cohort study Risk of bias risk reduction robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections screened searched statistically significant subsequent substantial reduction substantial reductions supplementary material systematic review tested transmission of SARS-CoV-2 Trial United Kingdom USA variants [DOI] 10.1186/s13756-021-01025-3 PMC 바로가기 [Article Type] Research
Rationale and Methods for a Randomized Controlled Trial of a Dyadic, Web-Based, Weight Loss Intervention among Cancer Survivors and Partners: The DUET StudyArticle Published on 2021-09-292022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] age Biomarker Cancer Cancer survivors Characteristics Controlled COVID-19 described diet dyads effective intervention enrolled Enrollment exclusion exercise Glucose Health homeostasis identify Inflammation Internet Intervention lifestyle Loss obesity performed physical activity Physical inactivity precluded Primary outcome promote Randomized controlled trial Randomly rationale RCT recruited Regulation Result rising secondary outcome Support survivor Survivors Two-arm Waist circumference weight weight loss [DOI] 10.3390/nu13103472 PMC 바로가기 [Article Type] Article