Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammationArticle Published on 2021-11-152022-10-04 Journal: Nature Communications [Category] 변종, [키워드] accelerate accompany activate activating Alzheimer's disease binding Brain cDNA Cognitive impairment disease extrinsic Genes HIV Human immunodeficiency virus in vitro in vivo induce Inflammation innate immune response Innate immunity Interaction interferon mechanism microglia microglial neurodegeneration neurodegenerative neurodegenerative disorders Neuroimmunology NFκB nuclear nuclear translocation pathway PQBP1 primary culture promote Protein receptor resulting Transcription Trigger virus infection [DOI] 10.1038/s41467-021-26851-2 PMC 바로가기 [Article Type] Article
Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar MacrophagesArticle Published on 2021-09-022022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] ACE-2 Activation activities Alpha alveolar macrophage analyzed angiotensin-converting enzyme-2 Anti-inflammatory anti-inflammatory property caused COVID-19 COVID19 COX2 cytokine demonstrated downregulation downstream IL-1β IL-6 immunomodulatory activity increase in inflammatory pathway Inflammatory response inhibit involved MAPK marker mechanism of action MOST murine murine alveolar macrophages NF-κB nitric oxide NLRP3 nuclear palmitoylethanolamide pathway primary culture proinflammatory receptor receptors reduced response SARS-CoV-2 SARS-CoV-2 spike glycoprotein selective several gene spike Spike protein tested therapeutic potential TLR4 TNF-α um-PEA upregulation [DOI] 10.3390/metabo11090592 PMC 바로가기 [Article Type] Article
The first few days of a SARS-CoV-2 infection viewed at single-cell resolutionSARS-CoV-2 감염의 처음 며칠 동안은 단일 세포 해상도로 볼 수 있습니다.Comment Published on 2021-04-262022-09-10 Journal: PLoS Biology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral Cell component coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 evaluated feature host response host responses Infection initial manuscript primary culture question respiratory respiratory virus SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell subsequent virus [DOI] 10.1371/journal.pbio.3001217 PMC 바로가기 [Article Type] Comment
Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial PeptoidsArticle Published on 2021-03-312022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activity Affect Air-liquid interface AMP AMPs antimicrobial antimicrobial peptide Antiviral antiviral activity Antiviral agents antiviral drug antiviral drugs antivirals appear approach Bioavailability candidate caused clinical development COVID-19 cryo-EM cytotoxicity effective epithelial cells examined Factors glycine Herpe host cell membranes HSV-1 in vitro incubated Infection infections LL-37 mechanism membrane disruption molecular feature oligomers peptides Peptoid peptoids potent primary culture Proteases Safe SARS-CoV-2 shown stability treat unique viral envelope viral particle virus viruses Visualization [DOI] 10.3390/ph14040304 PMC 바로가기 [Article Type] Article
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis갑상선 세포에서 SARS-COV-2 수용체 ACE-2 mRNA 검출: 코로나19 관련 아급성 갑상선염의 단서Original Article Published on 2020-10-062022-09-10 Journal: Journal of Endocrinological Investigation [Category] MERS, 진단, 치료제, [키워드] ACE-2 ACE-2 receptor angiotensin Angiotensin-converting enzyme carboxypeptidase Cell cell cultures cells cellular entry clinical study coronavirus COVID-19 described detection enzyme Ex vivo expressed expression follicular follicular cell follicular cells Future GAPDH human tissue in vitro independent involved mRNA nodules pandemic pathogenic pathway Patient patients with COVID-19 primary culture receptor Renin Renin-Angiotensin pathway reporter reporter genes required responsible Result RT-PCR SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection surgical the mean Thyrocytes Thyroid thyroid follicular cells thyroid nodules thyroidectomy Thyroiditis tissue sample tissues transcript transmembrane type I was performed β-actin [DOI] 10.1007/s40618-020-01436-w PMC 바로가기 [Article Type] Original Article
Primary cultures of aspiration residual specimens predict outcomes of hepatocellular carcinoma patients receiving curative treatmentArticle Published on 2020-09-012023-06-13 Journal: The Kaohsiung journal of medical sciences [Category] B형 간염, [키워드] fine-needle aspiration Hepatocellular carcinoma outcome primary culture recurrence [DOI] 10.1002/kjm2.12221
Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitisArticle Published on 2019-01-082022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, [키워드] administration Affect anti-viral response Apoptosis death demonstrated Depletion described double-stranded RNA early stage exacerbate fulminant viral hepatitis Genotype HBV HBV infection Hepatitis Hepatitis B virus hepatocyte homozygous infected patients labeling Liver damage liver parenchymal cell liver tissue Macrophage mice mimicking murine murine hepatitis virus Mutation pathogen-associated molecular polymorphism Prevent primary culture PROTECT Protein RIPK1 risk secreted severe symptom signaling pathway stimulated syndrome TNF-α to define transaminase triggered wild-type worsening [DOI] 10.1038/s41419-018-1277-3 PMC 바로가기 [Article Type] Article
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation말단 부속기 단백질 CEP164에 대한 조건부 녹아웃 마우스는 기도 다중섬모 세포 분화에서 필수적인 역할을 밝힙니다Research Article Published on 2017-12-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affecting airway airways arising Arl13b Asthma basal body binding Brain Cby1 Cell cell differentiation cells CEP164 cerebrospinal fluid characterized chronic obstructive ciliary ciliary dyskinesia circulation clearance component Control COPD Critical cystic fibrosis develop differentiation disease disorder distal docking dysfunction dyskinesia Evidence female reproductive tract fiber fibrosis fluids Genetic genetic disease GTPase Health human biology hydrocephalus implicated Infection infertility knockout mice lack lining male male infertility membrane vesicle membrane vesicles mice modulate molecular mechanism molecular mechanisms Mucociliary clearance Mucus multicilia oviduct Patient Perturbation physiological primary ciliary dyskinesia primary culture Protein Proteins provide recruitment regulate Regulation respiratory respiratory diseases selective Structure Symptom Testis tissue tracheal Transport unique Vesicle while [DOI] 10.1371/journal.pgen.1007128 PMC 바로가기 [Article Type] Research Article