pro-inflammatory mediators – Communicable Diseases Research

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells

스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다

Article

Published on 2022-06-122022-09-11
Journal: Molecules [Category] 유전자 메커니즘,

Dopamine Reduces SARS-CoV-2 Replication In Vitro through Downregulation of D2 Receptors and Upregulation of Type-I Interferons

도파민은 D2 수용체의 하향 조절 및 I형 인터페론의 상향 조절을 통해 시험관 내 SARS-CoV-2 복제를 감소시킵니다

Article

Published on 2022-05-192022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] administration affected Alter alteration Antiviral effect antiviral effects Calu Calu-3 Calu-3 cell line cell line correlation D2DR Dopamine doses downregulating downregulation epithelial Evidence expression Frame host cell IFN response IFNs immune response immune responses induce Inflammasome innate immune pathway innate immune pathways interferons Invasion ISG ISGs lung cells mechanisms mRNA NLRP3 NLRP3 inflammasome non-toxic occur pathway Pathways periphery pro-inflammatory mediators protein levels quinpirole quinpirole. recent receptor reduce reducing Replication robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly turn upregulate viral replication while
[DOI] 10.3390/cells11101691 PMC 바로가기 [Article Type] Article

In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release

미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향

Article

Published on 2022-04-062022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis
[DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article

Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19

SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할

Review

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료법,

[키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor
[DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review

Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients

의료 종사자 및 COVID-19 환자의 SARS-CoV-2 항체 및 염증 매개체 순환 수준의 비교 분석

Article

Published on 2022-02-232022-09-11
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] advance anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies Antiviral Asymptomatic Brazil CCL2 CCL2/MCP-1 chemokines clinical evolution Comparative contribute COVID-19 COVID-19 patient Cytokines cytokines/chemokines dead died evaluate explain Factor form group groups HCW healthcare healthcare worker Healthcare workers Host IFN-γ IgA IgG IL-10 IL-6 Imbalance individual individuals Inflammatory mediators Inflammatory response knowledge Level MCP-1 mediator mediators Mild pathology pathophysiology patients patients with COVID-19 pro-inflammatory mediator pro-inflammatory mediators recovered patient SARS-CoV-2 sick specific antibodies specific antibody symptomatic the disease TNF-α worker
[DOI] 10.3390/v14030455 PMC 바로가기 [Article Type] Article

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과

Research Article

Published on 2022-01-212022-09-10
Journal: eLife [Category] 변종,

[키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured
[DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article

Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury

COVID-19 급성 폐 손상과 관련된 염증성 사이토카인에 대한 다양한 치료 세포 유형 감수성의 직접 비교

Research

Published on 2022-01-152022-09-10
Journal: Stem Cell Research & Therapy [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alter Analysis ARDS ARDS patients Bone marrow Cell Cell therapy cell type cell viability cells characterized clinical evaluation clinical trial clinically Combination conditioned media COVID-19 COVID-19 ARDS patient cytokine Cytokine storm Cytokines Cytometry deleterious effect determine Direct Disease progression dose doses dysregulated immune response evaluate the effect excluded expression Extracellular Extracellular vesicles Flow flow cytometry greater high risk IL-6 immunomodulatory implicated Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators mediators Mesenchymal stromal cells Mild Mortality not altered Novel coronavirus paracrine pathology Patient pro-inflammatory mediator pro-inflammatory mediators progression proteomic receptor receptors respiratory distress Respiratory distress syndrome Result severe ARDS severe COVID-19 stem cell stem cells stromal cells supplementary material survival susceptibility syndrome the cell therapeutic therapeutic efficacy therapy Treatment umbilical Vesicle viability were assessed widespread with COVID-19
[DOI] 10.1186/s13287-021-02699-7 PMC 바로가기 [Article Type] Research

Advances and highlights in biomarkers of allergic diseases

알레르기 질환 바이오마커의 발전과 하이라이트

Review

Published on 2021-12-012022-09-11
Journal: Allergy [Category] SARS, 바이오마커,

[키워드] addition advance allergen allergen immunotherapy allergic allergic disease allergic diseases allergic rhinitis anaphylaxis approach Asthma asthmatic asthmatic patient Asthmatic patients atopic dermatitis Biomarker Biomarkers body fluid body fluids change characterized chronic urticaria clinically Clusters collected COVID-19 COVID-19 pandemic Data analysis diagnoses Diagnosis diagnosis and monitoring eosinophils epithelial food allergies fraction help highlight hypersensitivity immune response Immunotherapy include information Innate lymphoid cells lymphoid cells M2 macrophages macrophages management Mast cells mediators microbiota miRNAs nitric oxide noninvasive omics technologies outbreak parameter Perspective plethora point-of-care Precision precision medicine presenting pro-inflammatory mediators quantified recommendation Research robust serum sputum Th2 cells the disease therapeutic targets Treatment urticaria
[DOI] 10.1111/all.15089 PMC 바로가기 [Article Type] Review

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

Article

Published on 2021-10-152022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

[키워드] accompanied ACE2, angiotensin-converting enzyme II Activation acute respiratory distress acute respiratory syndrome ADAM17, metalloprotease 17 alarmin ALI, acute lung injuries approach AT1R, activation of angiotensin-1-receptor BAFFR, B-cell activating factor receptor BLC, B-lymphocyte chemoattractant bortezomib c-AMP, cyclic adenosine phosphate CASP3, caspase 3 CCL, chemokine ligand CD40⁺, cluster of differentiation 40 CDC, Center for Disease Control and Prevention chemokine coronavirus disease Coronavirus-2 Corticosteroid cough CoV, coronavirus COVID-19 COVID-19, Coronavirus disease 2019 COX-2, cyclooxygenase-2 cross-talk CRP C, reactive protein CTLs, cytotoxic T lymphocytes CXCL C-X-C, motif chemokine ligand CXCL, C-X-C- motif chemokine cytokine Cytokine storm Cytokine storm syndrome DAMP, damage-associated molecular patterns (DAMP) demonstrated Dexamethasone Diseases Dyspnoea dysregulated Effectiveness Enzymes ERK1/2, extracellular signal-regulated kinases expression feature Fever GSDMD, Gasdermin highlight Host Host immune response IKK, IκB kinase IL-1R, Interleukin 1 receptor (IL-1R) IL, interleukin immune dysregulation immune system Inflammation Inflammatory cytokine inhibitor iNOS, nitric oxide synthase IP-10, interferon-inducible protein 10 JAK, Janus kinase JNK, Jun amino-terminal kinases life-threatening LPS, lipopolysaccharides LTβR, Lymphotoxin-β receptor manifestation MAPK, Mitogen-activated protein kinase MAPKs, mitogen-activated protein kinases MCP-1, monocyte chemoattractant protein 1 MIG, monokine induced by interferon-γ MIP-1α and MIP-1β, macrophage inflammatory protein 1α and 1β, respectively monoclonal antibody morbidity and mortality multiple organ failure NEMO, regulatory subunit IKKγ NF-κB NF-κB, nuclear factor kappa B cells NF-κB NK, natural killer NO, Nitric Oxide Novel coronavirus nucleotide offer PAMPs, pathogen-associated molecular patterns pathway PKR, threonine-derived kinases pro-inflammatory mediators PTMs, post-translational modifications RANK, receptor activator of NF-κB Remdesivir responsible RSV, respiratory syncytial virus SARS-CoV-2 SARS, Severe acute respiratory syndrome Septic shock Severe acute respiratory syndrome severe complication severe COVID-19 patients Signal transduction significant decrease SMD, SOD, superoxide dismutase STAT3, signal transduction activator of transcription factor 3 STING, stimulator of interferon genes syndrome systemic inflammation Th, helper T cells therapeutic intervention therapeutic strategy therapy TLR-4, Toll-like receptor-4 TNF-α TNF, Tumour Necrosis Factor TNFR, tumour necrosis factor receptor tyrosine upregulating VEGF, Vascular endothelial growth factor
[DOI] 10.1016/j.intimp.2021.108255 PMC 바로가기 [Article Type] Article

Endothelial Cell Activation by SARS-CoV-2 Spike S1 Protein: A Crosstalk between Endothelium and Innate Immune Cells

Article

Published on 2021-09-142022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] “cytokine storm” activated Activation addressed adhesion molecules alteration amplify cell activation chemokine chemokines Coagulopathy Combination conditioned contributing to COVID-19 Crosstalk CXCL10/IP-10 Cytokines decrease endothelial activation Endothelial cell endothelial cells Endothelial dysfunction Endothelium Evidence expression human lung human monocyte-derived macrophage hyperinflammatory state ICAM-1 impairment increased expression Infection Inflammatory response Innate Macrophage macrophages MDM mechanism medium multi-organ failure occur Pathogenesis pro-inflammatory mediator pro-inflammatory mediators Protein prothrombotic state released S1 protein SARS-CoV-2 severe COVID-19 spike spike S1 protein THBD the disease the S1 protein the SARS-CoV-2 the spike protein tissue Vascular vascular homeostasis VCAM-1
[DOI] 10.3390/biomedicines9091220 PMC 바로가기 [Article Type] Article