Association between sex hormones and anti-S/RBD antibody responses to COVID-19 vaccines in healthcare workersResearch Article Published on 2023-11-142024-09-05 Journal: Human vaccines & immunotherapeutics [Category] update2024, [키워드] anti-S/RBD COVID-19 Estrogen Healthcare workers progesterone Sex difference Testosterone Vaccine [DOI] 10.1080/21645515.2023.2273697 PMC 바로가기 [Article Type] Research Article
The sex and gender dimensions of COVID-19: A narrative review of the potential underlying factorsReview article Published on 2022-09-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 ACE-2 receptor addition airway alcohol Biological difference cardiovascular diseases cells complex interplay coronavirus disease COVID-19 diabetes dimension discrepancy disorders downregulating Estrogen Evidence exhibited expression Factor Factors female females Gender Gender disparities health regulations Hormones immune response increase Infection involved kidney lung male Male sex males men men and women Mortality Multiple outcome outcomes progesterone protective role reduced risk risk factor Risk factors robust severe disease severity of COVID-19 Sex smoking Sociocultural effects statistically the SARS-CoV-2 viral infections virus with COVID-19 women [DOI] 10.1016/j.meegid.2022.105338 [Article Type] Review article
Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approachArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19 [DOI] 10.3389/fimmu.2022.975848 PMC 바로가기
The next two decades of mifepristone at FDA: History as destiny,Review article Published on 2022-05-012022-10-05 Journal: Contraception [Category] 비임상, [키워드] abortion approval drug FDA food history labeling mifepristone Pregnancy progesterone regulatory authority RU-486 unlikely [DOI] 10.1016/j.contraception.2022.01.016 [Article Type] Review article
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone프로게스테론에 의한 SARS-CoV-2를 포함한 바이러스에 대한 선천 면역 반응의 조절Article Published on 2022-04-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate Activation antiviral gene antiviral genes antiviral response Cell downstream Effects Host humoral hypothalamic-pituitary-adrenal axis immunomodulatory induce infectious Inflammatory diseases innate immune response IRF3 knockout metabolism mice modulate opposite PGR phosphorylate progesterone progesterone receptor promote receptor regulated SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients severity of COVID-19 SRC Stimulation transcriptional tyrosine viral infection virus [DOI] 10.1038/s41392-022-00981-5 PMC 바로가기 [Article Type] Article
Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model여성 성 호르몬인 프로게스테론은 시리아 햄스터 모델에서 SARS-CoV-2로 인한 폐렴의 심각성을 개선합니다Letter Published on 2022-02-142022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] Infection Infectious diseases Pneumonia progesterone severity Sex [DOI] 10.1038/s41392-021-00860-5 PMC 바로가기 [Article Type] Letter
Association Between Sex Hormone Levels and Clinical Outcomes in Patients With COVID-19 Admitted to Hospital: An Observational, Retrospective, Cohort StudyObservational Study Published on 2022-01-272022-10-04 Journal: Frontiers in Immunology [Category] 임상, [키워드] age ARDS association both sexes clinical cohort study confounders COVID-19 COVID-19 patients death estradiol hormone Hospitalized in-hospital mortality Italy Level male males median age Older outcome Patient Probability progesterone Protective Regression model reported retrospective severe COVID-19 severity Sex sex hormone Sex hormones stratified by sex STROBE survivor Testosterone understanding with COVID-19 [DOI] 10.3389/fimmu.2022.834851 PMC 바로가기 [Article Type] Observational Study
The impact of calcitriol and estradiol on the SARS-CoV-2 biological activity: a molecular modeling approachArticle Published on 2022-01-132022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 addition Affect Alter Angiotensin converting enzyme-2 approach binding binding energy clinical investigation Computational biophysics coronavirus coronavirus spike protein COVID-19 COVID-19 infected patient death Dexamethasone entry of SARS-CoV-2 facilitated Gender high risk host cell Hydrocortisone Interaction Invasion molecular Molecular modelling Mortality novel coronavirus disease Potential Prednisone progesterone protease protease active site recent reduce Replication replication of SARS-CoV-2 reported SARS-CoV-2 severity Spike protein spike trimer Structure the disease the SARS-CoV-2 the spike protein virus was increased [DOI] 10.1038/s41598-022-04778-y PMC 바로가기 [Article Type] Article
Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19Pharmacology Published on 2021-12-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulating Analysis bioinformatics analyses Bioinformatics analysis Biological functions comorbid disease Comorbidities Comorbidity condition conducted COPD COVID-19 COVID-19 pandemic data sets database Dexamethasone drug effective interventions enrichment analysis evidence of Factor Factors Host host factor interaction networks Identified Interaction Intersection management mechanism molecular mechanism network network analysis nitric oxide Ontology Pathway enrichment analysis Perspective progesterone protein-protein interaction Respiratory disease signaling pathway Transcription [DOI] 10.3389/fphar.2021.718874 PMC 바로가기 [Article Type] Pharmacology
Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trialRandomized Controlled Trial Published on 2021-11-302022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Admission adverse events Anti-inflammatory antibody production approved drug Biology center clinically Corticosteroids COVID-19 death determine disease severity double blind drug Efficacy Ethical approval Ethics evaluate food general endocrinology Hospital stay hospitalised Hospitalised patients HRT HRT. immune response immune tolerance include Infectious diseases Inflammatory biomarker intramuscular mechanical ventilation Medicine mitigate New New Orleans Occurrence Oestradiol outcome Participants Patient peer-reviewed Phase 2 Placebo placebo-controlled primary endpoint Primary outcome progesterone proportion randomised readmission reduce reducing Result Sample size secondary Sex sex steroids & Sponsor Standard of care steroid subjects submitted the WHO therapeutic option therapy Trial university USA was obtained WHO ordinal scale [DOI] 10.1136/bmjopen-2021-053684 PMC 바로가기 [Article Type] Randomized Controlled Trial