IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivoArticle Published on 2024-07-042024-09-05 Journal: bioRxiv [Category] update2024, [키워드] COVID-19 Eicosanoids IL-13 prostaglandin SARS-CoV-2 scRNA-seq [DOI] 10.1101/2024.07.03.601941 PMC 바로가기 [Article Type] Article
Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID-19비스테로이드성 소염제 및 기타 에이코사노이드 경로 조절제가 항바이러스 및 알레르기 반응에 미치는 영향: COVID-19 시대의 에이코사노이드 합의 보고서에 대한 EAACI 태스크포스Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료제, [키워드] allergic allergic diseases allergic inflammation allergy analgesic effect antagonist Anti-inflammatory anti-inflammatory drug Antipyretic Antiviral applied Asthma Biologicals biologicals. cannabinoids chronic inflammatory disease Consensus COVID-19 COVID-19 treatment Effect eicosanoid General population Horizon identify Inflammation Inflammatory diseases Interaction knowledge leukotriene leukotriene receptor antagonist leukotriene receptor antagonists LTRA mechanism mechanism of action medication medications NERD non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pandemic of COVID-19 pathway Pathways predict prostaglandin prostaglandin D2 Research Respiratory disease respiratory infections response SARS-CoV-2 selectivity Symptom therapy Treatment unmet need viral infection viral infections [DOI] 10.1111/all.15258 PMC 바로가기 [Article Type] Article
Characterization of prostanoids response to Bordetella pertussis antigen BscF and Tdap in LPS-challenged monocytesArticle Published on 2022-07-312024-09-02 Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids [Category] 백일해, 파상풍, [키워드] Bordetella pertussis lipids prostacyclin prostaglandin Prostanoid Vaccine PMC 바로가기
Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected MiceSARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication [DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article
Indomethacin-based PROTACs as pan-coronavirus antiviral agents범 코로나바이러스 항바이러스제로서의 인도메타신 기반 PROTACArticle Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents antiviral potency Chimera class coronavirus Coronavirus-2 CoVs demonstrated develop early stage example host protein human CoVs indicated indomethacin infected Vero E6 cells inhibit inhibit SARS-CoV-2 interact knowledge mechanism mechanism of action Nsp7 PGES-2 prostaglandin prostaglandin E PROTAC Protein proteolysis proteomic study Replication reported SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 strains Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support synthesis targeting the SARS-CoV-2 Vero E6 VERO E6 cells [DOI] 10.1016/j.ejmech.2021.113814 PMC 바로가기 [Article Type] Article
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19Dexamethasone은 심각한 COVID-19에서 미성숙 호중구와 인터페론 프로그래밍을 조절합니다Article Published on 2021-11-152022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료법, [키워드] activated acute respiratory distress acute respiratory distress syndrome affected affecting ARDS Bacterial cellular interaction cellular interactions characterized circulating neutrophils coronavirus disease Coronavirus disease 2019 COVID-19 Critical Defense develop Dexamethasone downregulated driver Effect expansion Host host defense IFN immature neutrophil immune immune cells immunosuppressive Immunotherapy information Innate innate immune cell Innate immune cells Innate immunity interferon interferon-stimulated gene interferon-stimulated genes mechanism modulate molecular mechanism molecular mechanisms neutrophil Neutrophils New outcomes Pathogens pathologic Patient plasma proteomics programming proportion prostaglandin respiratory respiratory distress Respiratory distress syndrome Respiratory pathogens severe COVID-19 Signaling single-cell Single-cell RNA sequencing steroid syndrome Target identification Therapeutic benefit viral infection [DOI] 10.1038/s41591-021-01576-3 PMC 바로가기 [Article Type] Article
Differential Effects of Prostaglandin D 2 Signaling on Macrophages and Microglia in Murine Coronavirus EncephalomyelitisResearch Article Published on 2021-09-072022-10-29 Journal: mBio [Category] Coronavirus, [키워드] absence activated Activation Central nervous system clearance CNS complex coronavirus disease Effect Encephalitis Encephalomyelitis expression identify immune response Infection infections infiltrating innate immune response Macrophage mice microglia mouse hepatitis virus (MHV) Ms4a3-cre murine myeloid cells neurotropic opposite PGD PGD2/DP1 axis phagocytosis prostaglandin receptor recruitment required resulting Signaling virus virus clearance [DOI] 10.1128/mBio.01969-21 PMC 바로가기 [Article Type] Research Article
Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitisArticle Published on 2021-08-102022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Biomarker C-reactive protein C-reactive protein (CRP changes in correlation CRP CRP level decrease enrolled Inflammatory bowel disease interval investigated metabolite mucosal Patient prospective observational study prostaglandin reduced reflected remained significantly ulcerative colitis Variation [DOI] 10.1038/s41598-021-95761-6 PMC 바로가기 [Article Type] Article
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease프로스타글란딘 E2에 의해 매개되는 손상된 면역 반응은 심각한 COVID-19 질병을 촉진합니다Research Article Published on 2021-08-042022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] affected age Anti-viral B-cell B-cells Blood level blood levels blood sample Blood samples courses COVID-19 disease COVID-19 patient COVID-19 patients cyclo-oxygenase Defense differentiation disease severity elevated enzyme epithelial cells expression immune response Immunity Impaired individual induce infected with SARS-CoV-2 infections inhibitor life style Lower lung lung epithelial cell Male sex master regulator memory old age Older age pandemic PAX5 PGE2 Precision Prevent proliferation promote prostaglandin prostaglandin E2 reduce reducing regular exercise risk SARS-CoV-2 SARS-CoV-2 coronavirus secretion serum Serum level serum levels severe COVID-19 disease severe disease severe disease course subjects survival Taxifolin Treatment upregulated upregulating [DOI] 10.1371/journal.pone.0255335 PMC 바로가기 [Article Type] Research Article
Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro SystemsSARS-COV-2 펩티드 및 LPS- 활성화 된 인간 시험 관내 시스템에서 살릭 피질 추출물 및 아세틸 살리실산의 비교 항 염증 효과Comparative Study Published on 2021-06-232022-08-31 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] Salix species Acetylsalicylic acid acetylsalicylic acid (ASA) acid activated Anti-inflammatory anti-inflammatory drug Anti-inflammatory drugs Anti-inflammatory effects anti-inflammatory treatment Cell cells co-culture Comparative compounds cortex COVID-19 patient Culture cytokine Cytokines Effect Efficacy enzyme activity Extract Fever Human human body human PBMC IL-10 IL-1β IL-6 IMPROVE in vitro in vitro data Inflammation Inflammatory ingredient intestinal liver cell LPS-activated mediator metabolism outcome Pain PBMCs peptide peptides PGE PGE2 precursor prostaglandin prostaglandin E2 protein expression retained salicin salicylic acid SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides suppressed suppression System therapy Willow willow bark [DOI] 10.3390/ijms22136766 PMC 바로가기 [Article Type] Comparative Study