SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumoniaArticle Published on 2024-08-132024-09-05 Journal: Nature Communications [Category] update2024, [키워드] DNA damage and repair Protein aggregation RNA splicing RNAi SARS-CoV-2 [DOI] 10.1038/s41467-024-51192-1 PMC 바로가기 [Article Type] Article
Reduction of hemagglutination induced by a SARS-CoV-2 spike protein fragment using an amyloid-binding benzothiazole amphiphileArticle Published on 2024-05-292024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Drug discovery and development peptides Protein aggregation [DOI] 10.1038/s41598-024-59585-4 PMC 바로가기 [Article Type] Article
Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregationResearch Article Published on 2024-04-232024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] deubiquitinase heterotypic aggregation Lewy body OTUB1 Parkinson's Disease Protein aggregation protein misfolding disease [DOI] 10.1016/j.jbc.2024.107315 PMC 바로가기 [Article Type] Research Article
Bioengineered amyloid peptide for rapid screening of inhibitors against main protease of SARS-CoV-2Article Published on 2024-03-072024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Biochemistry Biotechnology Nanoparticles Protein aggregation Screening [DOI] 10.1038/s41467-024-46296-7 PMC 바로가기 [Article Type] Article
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrilsarticle Published on 2023-04-252024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Nucleoproteins peptides Protein aggregation Target identification X-ray crystallography [DOI] 10.1038/s41467-023-37865-3 PMC 바로가기 [Article Type] article
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomesarticle Published on 2023-02-202024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Atomic force microscopy Protein aggregation viral infection [DOI] 10.1038/s41467-023-36234-4 PMC 바로가기 [Article Type] article
COVID-19 and Parkinson’s Disease: Possible Links in Pathology and TherapeuticsReview Published on 2022-10-012023-07-10 Journal: Neurotoxicity Research [Category] COVID19(2023년), [키워드] COVID-19 Dopamine Parkinson’s disease Protein aggregation SARS-CoV-2 Therapeutics α-synuclein. [DOI] 10.1007/s12640-022-00540-4 [Article Type] Review
In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologiesResearch Paper Published on 2021-07-052023-07-02 Journal: Biochimica et biophysica acta. Proteins and proteo [Category] SARS, [키워드] A3D, Aggrescan3D APR, aggregation-prone regions bioinformatics CoVex, Coronavirus Explorer COVID-19, coronavirus disease 19 NSP, Non-structural Proteins ORF, open reading frame PASTA, prediction of amyloid structural aggregation PDB, Protein Data Bank Protein aggregation Proteostasis SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 [DOI] 10.1016/j.bbapap.2021.140693 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegenerationSARS-CoV-2 스파이크 단백질과 아밀로이드 생성 단백질의 상호작용: 신경 퇴행에 대한 잠재적인 단서Article Published on 2021-05-212022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] accelerate aggregation assist bind binding Brain COVID-19 help heparin Heparin binding proteins include Interaction neurodegeneration neurologic outcome Post-infection Potential Prevent Protein Protein aggregation Proteins RBD Receptor binding domain S1 protein S1 RBD SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike protein shown spike Symptom the S1 protein the SARS-CoV-2 viral surface [DOI] 10.1016/j.bbrc.2021.03.100 PMC 바로가기 [Article Type] Article
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid proteinGCG는 뉴클레오캡시드 단백질의 액상 응축을 방해하여 SARS-CoV-2 복제를 억제합니다.Article Published on 2021-04-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, 치료제, [키워드] Amino acid amino acid substitutions binding coding sequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt disrupting exhibit gallate GCG Genome genome variant genomes GISAID GISAID database greater green tea identify IFN inhibit interfere knowledge leads nucleocapsid nucleocapsid protein polymorphism polyphenol Potential treatment predicted Protein Protein aggregation reveal RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication the SARS-CoV-2 Treatment Trigger triggers undergo Viral viral genome virion assembly viruses [DOI] 10.1038/s41467-021-22297-8 PMC 바로가기 [Article Type] Article