Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllersarticle Published on 2023-10-132024-09-05 Journal: mBio [Category] update2024, [키워드] cellular immunity COVID-19 Efficacy Humoral immunity immunogenicity nonhuman primate Protein subunit SARS-CoV-2 tetravalent Vaccines [DOI] 10.1128/mbio.02070-23 PMC 바로가기 [Article Type] article
Immunogenicity and safety of Biological E’s CORBEVAX™ vaccine compared to COVISHIELD™ (ChAdOx1 nCoV-19) vaccine studied in a phase-3, single blind, multicentre, randomized clinical trialCoronavirus Published on 2023-04-272024-09-05 Journal: Human vaccines & immunotherapeutics [Category] update2024, [키워드] COVID-19 Protein subunit Receptor binding domain SARS-CoV-2 Spike protein Vaccine [DOI] 10.1080/21645515.2023.2203632 PMC 바로가기 [Article Type] Coronavirus
Safety and immunogenicity of a recombinant receptor-binding domain-based protein subunit vaccine (Noora vaccine™) against COVID-19 in adults: A randomized, double-blind, placebo-controlled, Phase 1 trialClinical Trial Published on 2023-02-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] COVID-19 immunogenicity Noora vaccine Protein subunit Safety SARS-CoV-2 [DOI] 10.1002/jmv.28097 PMC 바로가기 [Article Type] Clinical Trial
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Safety, tolerability and immunogenicity of Biological E’s CORBEVAX™ vaccine in children and adolescents: A prospective, randomised, double-blind, placebo controlled, phase-2/3 studyClinical Trial Published on 2022-11-222023-07-10 Journal: Vaccine [Category] COVID19(2023년), [키워드] adverse events COVID-19 Neutralizing antibodies Protein subunit Receptor binding domain SARS-CoV-2 Vaccine [DOI] 10.1016/j.vaccine.2022.10.045 [Article Type] Clinical Trial
Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody AZD1222 booster vaccination cellular Cellular immune response cellular immune responses cellular immunity coronavirus COVID-19 Delta delta variant dose effective elevated elicit Emergency use authorization emerging variants evaluated Evidence Heterologous heterologous prime-boost heterologous vaccination humoral immune immune evasion immune response immune responses IMPROVE increase in induce Infection interferon mRNA mRNA vaccine mRNA-1273 Multiple Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevent priming promote Protein subunit protein subunit vaccine provided RBD Receptor binding domain reduced regimen response SARS-CoV-2 SARS-CoV-2 variants significantly subunit suggested T cell Taiwan vaccination vaccination schedule Vaccine variant variants Viral variants wild type [DOI] 10.1128/spectrum.00609-22 PMC 바로가기
Immunogenicity and safety of two-dose SARS-CoV-2 vaccination via different platforms in kidney transplantation recipientsArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered adverse effect analyzed Anti-spike antibody BNT162b2 cellular cellular response Cellular responses ChAdOx1 Characteristics coronavirus creatinine Efficacy elicited first dose highest humoral immunogenicity interferon-γ kidney kidney transplant mRNA mRNA1273 Patient patients platform positive Protein Protein subunit recipient rejection renal function SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose the patient the spike protein vaccination Vaccination strategy Vaccine Vaccines Viral vector [DOI] 10.3389/fimmu.2022.951576 PMC 바로가기
Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label, multicentre, and randomised phase-1/2 and phase-2 clinical trialsClinical Trial Published on 2022-08-122022-10-05 Journal: EBioMedicine [Category] SARS, 변종, 임상, 진단, [키워드] adverse event Anti-RBD IgG AstraZeneca baseline Biotechnology Cellular immune response cellular immune responses clinical clinical trial Coalition conducted convalescent serum correlation COVID-19 COVID-19 vaccination COVID-19 vaccine CpG1018 Department domain doses Efficacy finding foundation funding groups humoral immune responses incidence India Innovation Melinda Gate Moderna multicentre NAb neutralising antibody observation Open-label profile Protein subunit randomised randomly divided Receptor-binding domain Registered registry reported safety profile SARS-CoV-2 SARS-COV-2 infection second dose significantly Spike protein the vaccine titre titres Trial Vaccine [DOI] 10.1016/j.ebiom.2022.104217 [Article Type] Clinical Trial
The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human MonocytesSARS-CoV-2 핵단백질은 인간 단핵구에서 선천적 기억을 유도합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] Anti-inflammatory Bacterial COVID-19 Cytokines effector cells heat-inactivated virus Human immune system human monocyte human monocytes in vitro induce Infection infections Innate Innate immunity innate memory Interaction macrophages memory monocyte Monocytes N protein nucleocapsid nucleoprotein outcome phenomenon positive Protein Protein subunit reaction reactivity S1 and S2 SARS-CoV-2 Spike protein subsequent tested the Spike virus [DOI] 10.3389/fimmu.2022.963627 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article