Possible modulating functions of probiotic Lactiplantibacillus plantarum in particulate matter-associated pulmonary inflammationarticle Published on 2024-01-092024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] alveolar cell protection anti-inflammatory cytokines gut microbiota dysbiosis gut-lung axis Nrf2 activation probiotics supplementation pulmonary inflammation [DOI] 10.3389/fcimb.2023.1290914 PMC 바로가기 [Article Type] article
Engineered extracellular vesicles derived from dermal fibroblasts attenuate inflammation in a murine model of acute lung injuryArticle Published on 2023-10-052024-09-05 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] update2024, [키워드] anti-inflammatory extracellular vesicles Engineered extracellular vesicles Lung injury nonviral gene delivery novel nanocarriers pulmonary inflammation [DOI] 10.1002/adma.202210579 PMC 바로가기 [Article Type] Article
Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2article Published on 2023-05-192024-09-05 Journal: Journal of Nanobiotechnology [Category] update2024, [키워드] COVID-19 outer membrane vesicles pulmonary inflammation Sepsis Synthetic bacterial vesicles Vaccine [DOI] 10.1186/s12951-023-01928-w PMC 바로가기 [Article Type] article
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathwayArticle Published on 2023-01-302022-11-16 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, 치료기술, [키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α toll-like receptor 4 treated Treatment were assessed were measured [DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Novel application of [18F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)Article Published on 2022-09-012022-11-16 Journal: Nuclear medicine and biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation added BAL Blood Bronchoalveolar lavage Chest COVID-19 dendritic cell determine diagnostic increased expression Infection infection process Inflammation initial injection lesions lung lung tissue Lymph node marker nonhuman primates novel performed pet PET-CT positive post infection principal pulmonary pulmonary inflammation pulmonary lesion pulmonary lesions Rhesus monkey Rhesus monkeys SARS-CoV-2 Seven Swab swabs timepoint TSPO TSPO. viral respiratory infections [DOI] 10.1016/j.nucmedbio.2022.05.002 PMC 바로가기
The efficacy of combined therapy of qingfeiPaidu capsule and lianhuaqingwen capsule nursing interventions for hospitalized patients with COVID-19: A retrospective study of medical recordsRandomized Controlled Trial Published on 2022-08-122022-10-04 Journal: Medicine [Category] 임상, [키워드] affecting alleviate anti-inflammatory effect baseline Blood Blood urea nitrogen C-reactive protein caused Chinese circulating Clinical characteristics clinical symptom Clinical symptoms Combined Combined therapy COVID-19 COVID-19 patient criteria demonstrated discharge Efficacy enrolled global pandemic group groups Hospitalization hospitalized patient immune function individuals Inflammation Intervention Laboratory lactate dehydrogenase life-threatening lung Lymphocyte count medical record Medicine Mild Moderate COVID-19 outcome outcomes Patient patients with COVID-19 Prognosis pulmonary inflammation Randomly Retrospective study severity scores therapy Traditional Treatment were recorded White blood cells [DOI] 10.1097/MD.0000000000029964 PMC 바로가기 [Article Type] Randomized Controlled Trial
TRPC6 is altered in COVID-19 pneumoniaTRPC6은 COVID-19 폐렴에서 변경됩니다.Article Published on 2022-08-012022-09-11 Journal: Chemico-biological interactions [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggravate alveolar septa anatomical Capillaries cellular ciliated ciliated epithelium cough COVID COVID pneumonia COVID-19 COVID-19 pneumonia Dissection dissections distribution drugs Fever fibrosis Gene Expression Human human lung human lung tissue hyaline membrane hyaline membranes immunohistochemistry Inflammation inflammatory lesions inhibiting investigated involved lesions lung lung; molecular mechanism molecular mechanisms observation observations patients with COVID-19 Pneumonia pneumoniae processed Protein pulmonary inflammation reported Support Symptom target Therapies therapy tissue tissues TRP TRPC6 TRPC6 channels vessel wall was obtained [DOI] 10.1016/j.cbi.2022.109982 PMC 바로가기 [Article Type] Article
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Whole-genome sequencing reveals host factors underlying critical COVID-19전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제, [키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing [DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article