Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLproSARS-CoV-2 Papain-like Protease PLpro용 유전적으로 인코딩된 형광 센서Article Published on 2022-07-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acceptor Biliverdin Cell cleavage co-expression coronavirus COVID-19 detect Donor downstream Endoplasmic reticulum energy transfer enzymatic activity fluorescence intensity fluorescent fluorescent protein FRET genetically encoded probes HeLa cells increase in inhibitors lifecycle linker live cell live cell imaging live cells membrane mNeonGreen non-structural protein non-structural proteins nsp1 NSP2 Nsp3 Papain Papain-like protease PLPro polyprotein protease protease PLpro Protein SARS-CoV-2 SARS-CoV-2 propagation sensor separated Stage the SARS-CoV-2 translocation [DOI] 10.3390/ijms23147826 PMC 바로가기 [Article Type] Article
Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 증식에 대한 시험관내 항바이러스 효과 평가Article Published on 2022-04-272022-09-11 Journal: Marine Drugs [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Abalone abalone viscera addition Antiviral antiviral activity Antiviral effect COVID-19 discus Effect evaluated expression level followed by Haliotis immunofluorescence assay inhibit SARS-CoV-2 inhibited inhibitory effect Interference nucleocapsid Nucleocapsid proteins plaque Plaque titration polysaccharide polysaccharides Propagation Quantitative Replication RNA copies RNA copy RT-PCR analysis Sargassum SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2 spikes seaweed seaweed. Treatment Vero E6 VERO E6 cells viral entry viral infection viscera western blot [DOI] 10.3390/md20050296 PMC 바로가기 [Article Type] Article
Antibacterial and antiviral high-performance nanosystems to mitigate new SARS-CoV-2 variants of concernReview article Published on 2022-03-012022-10-05 Journal: Current Opinion in Biomedical Engineering [Category] 치료제, [키워드] Aerosols Antibacterial Antiviral Biomarker Coronavirus diseases 2019 COVID-19 infection COVID-19 pandemic COVID-19Coronavirus diseases 2019 Critical diagnostics droplets Effectiveness Effects facilitate FDAFood and Drug Administration FETField-effect-transistor Field-effect-transistor filtration Food and Drug Administration functional global healthcare Health immune response Infection Layer-by-Layer LBLLayer-by-Layer management Masks mitigate Mutation Nanosystem Neutralizing new SARS-CoV-2 NSNanosystem pandemic pathway Protective quarantine respiratory fluid SARS-CoV-2 propagation SARS-CoV-2 variant SARS-CoV-2severe acute respiratory syndrome coronavirus 2 selective severe acute respiratory syndrome coronavirus 2 Severe infection severity the SARS-CoV-2 Transmission Treatment variant variants of concern virus [DOI] 10.1016/j.cobme.2021.100363 [Article Type] Review article
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responsesMEK1/2 억제제 ATR-002는 SARS-CoV-2 전파를 효율적으로 차단하고 전염증성 사이토카인/케모카인 반응을 완화합니다Original Article Published on 2022-01-102022-09-10 Journal: Cellular and Molecular Life Sciences [Category] 치료제, [키워드] accelerated activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate anti-influenza drug Anti-SARS-CoV-2 Activity antiviral drug ATR-002 block cascade caused Cell Cell culture cell line cell lines clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression cultures Cytokines death Disease progression Drug evaluation early infection epithelial epithelial cell evaluated expression fibrosarcoma high-risk patient High-risk patients hyperinflammation impair Infection inhibitor kinase kinases knockdown limit medication MEK1/2-inhibitor mitogen mitogen-activated protein kinase Novel coronavirus observé pandemic pandemic spread pathway powerful tool Prevent pro-inflammatory pro-inflammatory cytokines Protein Raf/MEK/ERK respiratory response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 propagation selective severe acute respiratory syndrome Coronavirus Signaling specific inhibitor Spread supplementary material Symptom target therapeutic intervention Treatment upstream vaccination virus replication while [DOI] 10.1007/s00018-021-04085-1 PMC 바로가기 [Article Type] Original Article
Enhanced apoptosis as a possible mechanism to self-limit SARS-CoV-2 replication in porcine primary respiratory epithelial cells in contrast to human cellsArticle Published on 2021-12-102022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] ACE2 expression Activation Analysis Apoptosis apoptotic caspase Cell Clinical sign COVID-19 dose-dependent dose-dependent manner enhanced ferrets former hallmark hamsters Health HREC human cell humans Immune cell death in vivo infect Infection infectious dose investigated less mechanism Microbiology Morphological replicated reported respiratory epithelial cell respiratory epithelial cells SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication Seroconversion susceptibility susceptible therapeutic Transmission Treatment viral shedding virus [DOI] 10.1038/s41420-021-00781-w PMC 바로가기 [Article Type] Article
Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmissionResearch Article Published on 2021-11-232022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] animal Combination comparable Contact correlated COVID-19 cycle Endemic heterogeneous high risk immune protection Immunity in both group Infection initial intranasally modeling natural infection Observed occur ranged RAT Result risk SARS-CoV-2 SARS-CoV-2 propagation seroconversion rate seropositive stability susceptible susceptible individuals threshold value Transmission vaccinated individual vaccinated individuals vaccination viral shedding virus [DOI] 10.1371/journal.pone.0260038 PMC 바로가기 [Article Type] Research Article
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung CellsPharmacology Published on 2021-10-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses [DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh방글라데시 SARS-CoV-2 게놈의 돌연변이 빈도의 시간적 풍경: 방글라데시에서 진행 중인 발병의 가능한 의미Article Published on 2021-10-012022-09-11 Journal: Virus Genes [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] age Analysis association Bangladesh change circulating condition conserved country COVID-19 D614G D614G mutation envelope envelope protein Evolution facilitate Factor Frequency function Genome GISAID Helicase implication intrinsic majority Model molecular phylogeny Mutation N protein nonspecific NSP11 NSP2 Nsp3 Nsp9 nucleocapsid protein ORF ORF3a ORF7b outbreak P323L performed platform Protein protein structure RdRP reference genome S2 domain SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 propagation SARS-CoV-2 strain selective sequenced Sex Spike protein strain susceptibility Temporal the Spike unique Vaccine development [DOI] 10.1007/s11262-021-01860-x PMC 바로가기 [Article Type] Article
Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation강력한 C형 간염 바이러스 프로테아제 억제제인 Asunaprevir, SARS-CoV-2 전파 차단Article Published on 2021-09-302022-09-11 Journal: Molecules and cells [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity asunaprevir binding block blocked calu-3 cells candidate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytopathic effect cytopathic effects daclatasvir direct-acting antiviral Drug repurposing evaluated Health hepatitis C hepatitis C virus human lung human lung Calu-3 cells include infected cells inhibited inhibitor life cycle NS5A pandemic potent Propagation Protease inhibitor protein level protein levels RNA RNA polymerase inhibitor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 vaccine SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus significantly sofosbuvir therapeutic agent Treatment vaccination Vero E6 VERO E6 cells viral life cycle virion [DOI] 10.14348/molcells.2021.0076 PMC 바로가기 [Article Type] Article
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19비강 섬모 세포는 COVID-19 초기 단계에서 SARS-CoV-2 복제의 주요 표적입니다Article Published on 2021-07-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, 치료기술, 치료제, [키워드] addition Analysis apical side cells cellular cellular tropism ciliated ciliated cell ciliated cells COVID-19 defined early stage epithelial cells Evidence host molecule host molecules Infectious disease Molecular pathology mRNA expression nasal Nasal Epithelial cells nasal epithelium pathology patients with COVID-19 precursor Prevent protein level protein levels replaced REPLACED BY replicated respiratory SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication single-cell squamous epithelium target upper respiratory tract [DOI] 10.1172/JCI148517 PMC 바로가기 [Article Type] Article