SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Evaluation of Seropositivity Following BNT162b2 Messenger RNA Vaccination for SARS-CoV-2 in Patients Undergoing Treatment for Cancer암 치료를 받는 환자에서 SARS-CoV-2에 대한 BNT162b2 메신저 RNA 백신 접종 후 혈청 양성 평가Research Published on 2021-05-282022-09-12 Journal: JAMA Oncology [Category] MERS, SARS, 진단, [키워드] 95% CI accompanied active treatment age analyses Analysis analyzed anti-S Antibody Response Antibody titer anticancer Beilinson Hospital blood sample Blood samples BNT162b2 BNT162b2 vaccine Cancer center Chemotherapy cohort study comparison Comparisons conducted Control control group COVID-19 COVID-19 disease Davidoff defined develop domain Enrollment evaluate exhibited Factor finding greater healthy control healthy controls high risk higher risk IgG IgG antibodies IgG antibody IgG titer IgG titers immunoassay Immunotherapy Importance intravenous measure median men messenger Messenger RNA multivariable analyses multivariable analysis objective outcome participant Participants Patient Patients with cancer Point Primary outcome prospective cohort study receiving Relevance required Research respond Result RNA SARS-CoV 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose second messenger secondary Secondary outcomes seropositive Seropositivity serum sample serum samples setting severe COVID-19 disease significantly significantly lower solid tumor solid tumors Study participants Support systemic therapy systemic treatment the patient therapy titers Treatment Tumor tumors vaccination vaccine dose [DOI] 10.1001/jamaoncol.2021.2155 PMC 바로가기 [Article Type] Research
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signalingNAADP 유발 Ca 2+ 신호에서 JPT2에 대한 필수 요구 사항Article Published on 2021-03-232022-09-11 Journal: Science Signaling [Category] SARS, 유전자 메커니즘, [키워드] acidic organelle acidic organelles Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine component Coronaviral coronaviral entry coronavirus endolysosomal endolysosomal system Essential events homolog identity JPT2 Jupiter nicotinic acid phosphate Protein pseudovirus receptor complex regulate Release required SARS-CoV-2 second messenger sensitivity severe acute respiratory syndrome Coronavirus Signaling translocation [DOI] 10.1126/scisignal.abd5605 PMC 바로가기 [Article Type] Article
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article