Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial중환자 기계 환기 환자의 불안, 섬망 및 인공 호흡기 일에 대한 덱스메데토미딘 진정 요법의 자가 투여 효과를 테스트하기 위한 연구 프로토콜: 공개 라벨 무작위 임상 시험Article Published on 2022-05-162022-09-11 Journal: Trials [Category] 임상, [키워드] addition aggregate alertness alleviate alteration Anxiety approach approaches assigned Care change clinical Clinical practice clinical trial Consistency Course COVID-19 case COVID-19 pandemic Critically ill delirium Depression dexmedetomidine distress Efficacy eligible Eligible participants eligible patient Eligible patients enrolment equipment extubation finding flexible functional Functional status healthcare ICU ICU care ICU patient ICU Patients identify impacted imperative intensive care intensive care unit life management Mechanical mechanical ventilation mechanical ventilatory support mechanically ventilated mechanically ventilated patient mechanically ventilated patients medication Open-label opioid outcome Oxygenation Pain Patient patient symptom Patient symptoms physical Post-traumatic stress disorder Protective protocol Psychological well-being Quality of life randomization Randomized randomized clinical trial Randomly receiving recruitment Secondary objective Secondary objectives Sedation sedative Self-management Side effects significantly study population subset Symptom therapy Trial trial enrolment usual care ventilator ventilator-free day Ventilator-free days ventilatory support [DOI] 10.1186/s13063-022-06391-w PMC 바로가기 [Article Type] Article
Trends of Cocaine Use and Manifestations in Hospitalized Patients: A Cross-Sectional StudyArticle Published on 2022-02-102023-08-30 Journal: Cureus [Category] E형 간염, [키워드] Abuse alcohol cocaine financial burden hallucinogen marijuana opioid sedative Stimulant trend [DOI] 10.7759/cureus.22090 PMC 바로가기
Associated Factors of High Sedative Requirements within Patients with Moderate to Severe COVID-19 ARDSArticle Published on 2022-01-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome addition affected age Analysis ARDS cause Combination conditions coronavirus coronavirus disease COVID-19 Critical care Critically ill demonstrated dysfunction enrolled extracorporeal membrane oxygenation Factor global healthcare High dose hypnotics and sedatives intensive care Linear regression model mechanism observation period Organ failure pandemic Patient patients Prone position prone positioning pulmonary ventilation receiving renal required Requirement Sedation sedative severe acute respiratory syndrome coronavirus 2 significantly higher significantly lower statistical analysis syndrome therapy was performed [DOI] 10.3390/jcm11030588 PMC 바로가기 [Article Type] Article
Use of Sedatives and Neuromuscular-Blocking Agents in Mechanically Ventilated Patients with COVID-19 ARDSArticle Published on 2021-11-202022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome administration agent ARDS ARDS patient baseline Combination Complication conditions COVID patient COVID-19 COVID-19 patient demographics drug implication inclusion criteria intensive care unit median neuromuscular-blocking agents Observational cohort study on mechanical ventilation Patient patients patients with COVID-19 protocol receiving regimen Sedation sedative significantly increased single-center syndrome therapy with COVID-19 [DOI] 10.3390/microorganisms9112393 PMC 바로가기 [Article Type] Article
Could the antipsychotic chlorpromazine be a potential treatment for SARS-CoV-2?항정신병제인 클로르프로마진이 SARS-CoV-2의 잠재적 치료제가 될 수 있습니까?Article Published on 2020-09-012022-09-11 Journal: Schizophrenia research [Category] 신약개발, [키워드] Abstract chlorpromazine clathrin Clathrin-mediated endocytosis Potential treatment Replication SARS-CoV-2 sedative Sedative medication Viral viral replication [DOI] 10.1016/j.schres.2020.07.015 PMC 바로가기 [Article Type] Article