A randomized, placebo-controlled pilot study of upamostat, a host-directed serine protease inhibitor, for outpatient treatment of COVID-19Randomized Controlled Trial Published on 2023-03-012023-07-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] clinical trial COVID-19 SARS-CoV-2 serine protease inhibitor Upamostat. [DOI] 10.1016/j.ijid.2022.12.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus [DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic ApplicationReview Published on 2022-02-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] alpha-1 antitrypsin alpha-1 antitrypsin deficiency anti-inflammatory activity antitrypsin application binding canonical Cell changes in circulation cleavage Complement C3 complex Coronavirus disease 2019 (COVID-19) Critical cytokine Cytokines disorder electrostatic hydrophobic immune response immunomodulatory increasingly innate immune interactions interleukin-6 mechanism methionine modulate molecular neutralise partner Potential protease Proteases Protein protein-protein interaction reactive residue review serine protease inhibitor therapeutic therapy [DOI] 10.3390/ijms23052441 PMC 바로가기 [Article Type] Review
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway culturesResearch Article Published on 2022-02-022022-10-30 Journal: Life Science Alliance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome administration air–liquid interface airway angiotensin-converting enzyme-2 apical surface binding Bioavailability blockade blocked Camostat mesylate Cell circulation cleavage clinical trial compounds coronavirus COVID-19 Culture cultures demonstrated develop effective enzalutamide epithelial cell evaluated experiment had no human airway Infection Local metabolised Prevent primary human airway Prophylaxis receptor restrict Safe SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection serine protease serine protease inhibitor Spike protein targeting therapeutic therapeutic strategy TMPRSS2 TMPRSS2 inhibitor topical transmembrane serine protease Treatment Viral transmission [DOI] 10.26508/lsa.202101116 PMC 바로가기 [Article Type] Research Article
Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of CoronavirusesArticle Published on 2022-01-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] caused coronavirus CoV CoVs disease drug evaluated expression frameshift identifying in viral inhibit inhibited inhibitor Ligand MERS-CoV mRNA negative controls outbreak programmed ribosomal frameshifting provide Recurrent SARS-CoV-2 serine protease inhibitor significantly Spectrum stimulate subset suppressed Therapeutics translation viability Viral proteins virus zoonoses Zoonotic coronavirus [DOI] 10.3390/v14020177 PMC 바로가기 [Article Type] Article
Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illnessResearch Published on 2022-01-062022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, [키워드] addition administration Analysis animal model anti-inflammatory actions anti-inflammatory effect Anti-viral behavioural Blood Brain circulating leukocytes CNS collected COVID-19 CXCL1 CXCL10 cytokine production DMSO evaluated evidenced examined Exogenous expression had no host response IFN-γ immunohistochemistry immunomodulatory effects increased expression induce Inflammation Inflammatory response inhibit inhibiting injection Intravenous injection liver lung marker mice nafamostat pathology phenotype provide qPCR reduce reducing restored Result robust serine protease inhibitor shown Sickness Sickness behaviour significantly ssRNA suppressed systemic inflammation temperature TLR7/8 TMPRSS2 TNF Treatment treatment for COVID-19 turn viral cell viral infection virus virus infection was determined [DOI] 10.1186/s12974-021-02357-y PMC 바로가기 [Article Type] Research
Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic InflammationChemistry Published on 2021-11-152022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] activated activity biochemical cardiovascular cardiovascular disease cathepsin G chronic chronic inflammatory disorders Comorbidity complications COVID-19 immune defense immunological indicated Inflammation management neutrophil Neutrophil elastase proteinase 3 proteolytic activity SARS-CoV-2 selective serine protease serine protease inhibitor serine protease inhibitors serine proteases Support thrombosis [DOI] 10.3389/fchem.2021.784003 PMC 바로가기 [Article Type] Chemistry
[Progress of researches on serine protease inhibitors for zoonotic cestode family Taeniidae]Review Published on 2021-11-012023-06-22 Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of [Category] 조류인플루엔자, [키워드] Cestode family Taeniidae Immune escape serine protease inhibitor zoonosis [DOI] 10.16250/j.32.1374.2021024 [Article Type] Review