severely infected patients – Communicable Diseases Research

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

흰 족제비에서 SARS-CoV-2 감염의 연령 의존적 병원성 특성

Article

Published on 2022-01-102022-09-12
Journal: Nature Communications [Category] SARS, 진단, 치료기술,

[키워드] activated T cells age Characteristics clinical symptom Clinical symptoms Contact COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity direct contact ferret ferrets gene expression profile group groups healthy Human individuals infected with SARS-CoV-2 Infection inflammatory cell inflammatory cell infiltration interferon lung Macrophage macrophage responses manifestation mimicking nasal not differ Older Pathogenesis pathogenesis of SARS-CoV-2 pathogenic Patient reveal SARS-CoV-2 SARS-COV-2 infection Seroprevalence severe COVID-19 patients severe symptom severe symptoms severely infected patients significantly T cells Transcriptome transcriptome analysis transcriptomic profile Transmission type I interferon Viral host response viral loads Viral transmission virus while
[DOI] 10.1038/s41467-021-27717-3 PMC 바로가기 [Article Type] Article

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.

Article

Published on 2021-12-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article

SARS-CoV-2: is there neuroinvasion?

SARS-CoV-2: 신경 침범이 있습니까?

Review

Published on 2021-07-142022-09-10
Journal: Fluids and Barriers of the CNS [Category] 치료기술,

[키워드] ACE2 ACE2 distribution acute respiratory distress acute respiratory distress syndrome Affect aging Blood–brain barrier (BBB) Brain brains breadth Cerebrospinal fluid (CSF) Choroid plexus CNS Complication complications conditions Consensus contribute coronavirus CoV COVID-19 CSF diabete diabetes disease distress distribution Effects Evidence evidence of flux Health health condition help hypertension include information inhalation Invasion main receptor male mechanism medical condition MMP9 mucosa multiorgan failure neurological Neurological complications neurological manifestation neurological manifestations neurological problems Neuron neurons obesity Older olfactory outcome outlined parenchyma pathway Pathways Patient present Replication respiratory respiratory distress Respiratory distress syndrome Respiratory system route of infection SARS-CoV-2 SARS-CoV-2 neuroinvasion severely infected patients significantly syndrome tissues understanding Vascular vascular dysfunction vessels virus while
[DOI] 10.1186/s12987-021-00267-y PMC 바로가기 [Article Type] Review

SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

SARS-CoV-2 조기 감염 시그니처는 잠재적인 주요 감염 메커니즘 및 약물 표적 식별

Research Article

Published on 2021-02-182022-09-10
Journal: BMC Genomics [Category] MERS, 신약개발, 유전자 메커니즘,

[키워드] addition antidepressants association atorvastatin BALF BALF cells bimodal biopsies Bronchoalveolar lavage fluid Bronchoalveolar lavage fluid cells candidate Candidates caused Cell characterized COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 outbreak COVID-19 treatments cultured cell cultured cells database dataset deaths Differential gene expression disease drug drug target early infection effective Efficacy expression profile Gene Expression gene signature HDAC healthy healthy and infected patients highlighting ibuprofen identify IFIT2 Immune cell immune cells infected patient infected with SARS-CoV-2 Infection infection mechanism inhibitors investigated ketoconazole lung lung biopsies mechanism moderate mononuclear cell mononuclear cells Mortality NFKBIA PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPP1R15A Previous studies previous study public health Result robust safety profile SARS-CoV-2 SARS-CoV-2 gene expression signature SARS-COV-2 infection Sequencing severely infected patient severely infected patients severity shown signature single-cell supplementary material the disease the SARS-CoV-2 therapy TNFAIP3 transcriptional activity treating SARS-CoV-2 infection Treatment Vaccine
[DOI] 10.1186/s12864-021-07433-4 PMC 바로가기 [Article Type] Research Article

Impact of congestive heart failure and role of cardiac biomarkers in COVID-19 patients: A systematic review and meta-analysis

코로나19 환자에서 울혈성 심부전의 영향과 심장 바이오마커의 역할: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-01-012022-08-31
Journal: Indian heart journal [Category] MERS, SARS, 바이오마커,

[키워드] 95% CI Acute cardiac injury appear Biomarker Biomarkers BNP cardiac Cardiac arrhythmia cardiac arrhythmias Cardiac biomarkers cardiac injury cardiovascular comorbidities cardiovascular disease CK-MB collected conducted congestive heart failure coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients database Deceased determined by disease severity elevated Google Scholar hypertension identify Impact in-hospital mortality increased risk mean difference Meta-analysis Mortality mortality risk non-survivor NT-proBNP outcome outcomes Patient paucity of data Prognosis Relative risk reported risk risk factor Risk factors selected severe disease severely infected patients significantly survival systematic review troponin Troponin-I was used
[DOI] 10.1016/j.ihj.2020.12.002 PMC 바로가기 [Article Type] Meta-Analysis

Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease

Article

Published on 2020-06-242022-10-31
Journal: Computation (Basel, Switzerland) [Category] COVID-19,