Siddha – Communicable Diseases Research

Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspective

Review article

Published on 2022-10-012022-10-05
Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 변종, 신약개발,

Phytochemical Discrimination, Biological Activity and Molecular Docking of Water-Soluble Inhibitors from Saussurea costus Herb against Main Protease of SARS-CoV-2

SARS-CoV-2의 주요 프로테아제에 대한 Saussurea costus Herb의 수용성 억제제의 식물화학적 판별, 생물학적 활성 및 분자 도킹

Article

Published on 2022-08-012022-09-11
Journal: Molecules [Category] SARS, 변종,

[키워드] activity andrographolide ATCC Bacterial binding affinity Bioavailability Biological biological activity carbohydrate carbohydrates carboxylic acid catalytic dyad Cell cell entry Compound coronavirus coronavirus SARS-CoV-2 costus COVID-19 Cys145 D614G variant Delta discrimination docked Escherichia coli event Fatty acid fatty acids FIVE followed by Gamma gas chromatography Gas Chromatography-Mass Spectrometry GC-MS GC-MS profiling Herb His41 HSV-1 virus inhibit inhibitor inhibitory effect investigated M pro main protease mass spectrometry medical system molecular docking phytochemical preference prevalent protease Protein pseudovirus ranged residue room temperature SARS-CoV-2 SARS-CoV-2 entry Saussurea Saussurea costus Siddha spike Spike proteins Staphylococcus aureus Sterol Strains tannin tannins temperature these compounds variant virucidal virus VoC water
[DOI] 10.3390/molecules27154908 PMC 바로가기 [Article Type] Article

Safety and efficacy of a Siddha Medicine fixed regimen for the treatment of asymptomatic and mild COVID-19 patients

Research article

Published on 2022-07-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 신약개발, 치료법,

[키워드] Admission All participant anti-SARS-CoV-2 antibody test antibody Asymptomatic Asymptomatic COVID-19 cardiac caused CBC Chennai clinical coronavirus 2 Coronavirus disease 2019 COVID COVID-19 COVID-19 disease COVID-19 patient cycle threshold Efficacy Electrolyte exploratory fixed function Intervention Kaba Sura Kudineer laboratory investigation Medicine Mild mild COVID-19 patient mild COVID-19 symptom negative non-randomized trial Notchi Kudineer oropharyngeal swab pandemic participant patients performed positive progression Proteins public health recruited reduce reduced regimen respiratory Result RT-PCR Safety SARS-CoV-2 severity severity of symptom Siddha Siddha Medicine significantly single-arm south India Standalone intervention Sura Symptom Symptomatic patients Tablet tablets Test Total treated Treatment Trial vitals
[DOI] 10.1016/j.jaim.2022.100589 [Article Type] Research article

A case report of moderate COVID 19 patient managed through integrative approach (Siddha and conventional medicine)

Case report

Published on 2022-07-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 치료제,

Safety and Efficacy of Siddha Medicine preparation in the management of COVID-19: A Prospective Randomised Open Label Study

Research article

Published on 2022-07-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 임상,

[키워드] 1:1 adverse events age average AYUSH baseline breathing ambient air CAM therapy clinical marker clinical symptom clinical trial complementary conducted control group COVID 19 patients COVID-19 COVID-19 patients Efficacy and safety group hospitalisation Hospitalized interquartile range Intervention intervention group lAbel management Medicine Mild Moderate COVID-19 objective open label oxygen saturation pandemic participated Patient patients hospitalized primary end point Prospective randomised Randomized receiving reduction in reported Result Safety SARS-COV-2 infection Seven Siddha spread of COVID-19 standard care statistically Symptom therapy Traditional medicine Trial two group
[DOI] 10.1016/j.jaim.2022.100597 [Article Type] Research article

Repurposing Siddha mercurial drug for mild to moderate COVID-19 – Case series and exploration of its chemical profile

Case report

Published on 2022-04-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발,

[키워드] 1H-Imidazole 9,12-Octadecadienoic acid acute respiratory syndrome age Ayurveda body temperature Chemical profile Chest compounds coronavirus cough COVID-19 COVID-19 patients Drug discovery female Fever first dose Gas Chromatography-Mass Spectrometry home quarantine infected patient Inflammatory diseases kidney liver Liver function loss of taste male Mercury Mild moderate Moderate COVID-19 normalized oxygen saturation Pain parameter plasma positive renal function renal impairment repeated repurposing required Research RT-PCR Safe SARS-CoV-2 Siddha Side-effect Swab Symptom therapy Traditional medicine treat treated Treatment Vajra was done were assessed X-ray/CT
[DOI] 10.1016/j.jaim.2021.06.009 [Article Type] Case report

An open clinical evaluation of selected siddha regimen in expediting the management of COVID-19 –a randomized controlled study

Research article

Published on 2022-01-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발,

[키워드] 2019-nCoV accelerated Accelerated recovery acute respiratory disease addition analyzed assigned Asymptomatic average benefit Care caused clinical evaluation clinical study COVID COVID-19 CT chest drug evaluate group infections limit lung involvement management material Mild moderate NLR novel corona virus objective open label parameter Patient polymerase chain Randomized randomized controlled study Ratio reduction regimen Result RT-PCR Sample size SARS-CoV-2 selected Siddha Siddha strategy standard treatment standard treatment alone subject Symptom synergistic synergistic effect Treatment Virus Disease
[DOI] 10.1016/j.jaim.2021.01.002 [Article Type] Research article

Structure-based docking, pharmacokinetic evaluation, and molecular dynamics-guided evaluation of traditional formulation against SARS-CoV-2 spike protein receptor bind domain and ACE2 receptor complex

Original Paper

Published on 2021-10-182022-10-31
Journal: Chemicke Zvesti [Category] COVID-19,

[키워드] ACE2 ACE2 receptor Analysis angiotensin-converting enzyme 2 antiviral property binding caffeic acid Cell classical clinical trial complex Computational docking study docking docking score domain Favipiravir FIVE Glide in silico in vivo experiment Interaction Kabasura kudineer Ligand MD simulation molecular molecular dynamics nontoxic outbreak pandemic PDB pharmacokinetic preventive measure Protein RBD receptor residue ribavirin SARS-CoV-2 SARS-CoV-2 spike protein selected Selection Shwas kuthar rasa Siddha suggested supplementary material Talisadi churna the SARS-CoV-2 therapeutic viral entry was performed was used
[DOI] 10.1007/s11696-021-01917-z PMC 바로가기 [Article Type] Original Paper

Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, India

Randomized Controlled Trial

Published on 2021-09-152022-10-04
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 95% CI adverse effect adverse event age Asymptomatic Asymptomatic COVID-19 Asymptomatic COVID-19 cases AYUSH Biochemical parameters changes in Chennai clinical clinical examination clinical presentation clinical symptom co-morbidities conducted control group coronavirus disease COVID COVID-19 COVID-19 cases Ct value declined drug Efficacy effort exploratory groups IFNγ IL-10 IL-2 IL-6 Immunity in both groups India individual interferon gamma Kabasura kudineer marker Necrosis no significant difference observé Occurrence Polyherbal decoction polymerase chain Primary outcome progressed progression Randomized Randomized controlled trial randomized, controlled trial recruited reduced reducing reduction in registry Result SARS-CoV-2 viral load Secondary outcomes Siddha Siddha Medicine significantly single-center Standard of care statistical analysis symptomatic t -test the disease the SARS-CoV-2 the study group threshold TNF α Traditional medicine Trial Vaccine Viral load Vitamin C was used
[DOI] 10.1186/s13063-021-05583-0 PMC 바로가기 [Article Type] Randomized Controlled Trial

Efficacy of two siddha polyherbal decoctions, Nilavembu Kudineer and Kaba Sura Kudineer, along with standard allopathy treatment in the management of mild to moderate symptomatic COVID-19 patients—a double-blind, placebo-controlled, clinical trial

Randomized Controlled Trial

Published on 2021-08-282022-10-04
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] acute respiratory syndrome Adverse adverse effect adverse event age analyzed Arm ARMS assessment Asymptomatic baseline blood biochemical breathlessness C-reactive protein clinical symptom clinical trial Coronavirus-2 cough COVID-19 COVID-19 patient CRP D-dimer diagnosed diarrhea discharge discharged disease double-blind Double-blinded RCT drug ECG Effect effective Efficacy Electrolyte enrolled evaluate event female ferritin Fever hospital Hospital stay ICU IL6 Inflammatory marker intensive care interleukin-6 Kaba Sura Kudineer Kruskal-Wallis test lactate dehydrogenase LDH Liver function main outcome measure male management mean value Medicines Mild Mild to moderate COVID-19 moderate Moderate COVID-19 Nilavembu kudineer not significantly different parameter participant Patient Placebo placebo-controlled primary outcome measure Public health intervention pursuit Randomized recorded recruited reduction in renal function respective treatment Result RT-PCR Safe SARS-CoV-2 SARS-CoV-2 viral load severe symptom Siddha Siddha Medicine significantly statistically significant reduction Sura Symptom symptomatic the patient the placebo group therapy three group Treatment viral epidemics Viral load virus vomiting were recorded while
[DOI] 10.1186/s13063-021-05478-0 PMC 바로가기 [Article Type] Randomized Controlled Trial