Identification of epithelial-related artificial neural network prognostic models for the prediction of bladder cancer prognosis through comprehensive analysis of single-cell and bulk RNA sequencingResearch Article Published on 2024-07-172024-09-05 Journal: Heliyon [Category] update2024, [키워드] Artificial neural network prognostic models Bladder cancer machine learning NFIC single-cell analysis [DOI] 10.1016/j.heliyon.2024.e34632 PMC 바로가기 [Article Type] Research Article
scNovel: a scalable deep learning-based network for novel rare cell discovery in single-cell transcriptomicsProblem Solving Protocol Published on 2024-05-282024-09-05 Journal: Briefings in Bioinformatics [Category] update2024, [키워드] Neural network novel rare cell discovery single-cell analysis [DOI] 10.1093/bib/bbae112 PMC 바로가기 [Article Type] Problem Solving Protocol
Recent methodological advances towards single-cell proteomicsReview Published on 2023-10-112024-09-05 Journal: Proceedings of the Japan Academy. Series B, Physic [Category] update2024, [키워드] proteomics single-cell analysis single-cell omics single-molecule microscopy [DOI] 10.2183/pjab.99.021 PMC 바로가기 [Article Type] Review
Cell-Specific Mechanisms in the Heart of COVID-19 Patientsarticle Published on 2023-05-122024-09-05 Journal: European archives of psychiatry and clinical neuro [Category] update2024, [키워드] COVID-19 endothelial cells Myocardium pericytes single-cell analysis Thromboinflammation viral tropism [DOI] 10.1161/CIRCRESAHA.123.321876 PMC 바로가기 [Article Type] article
Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccinationArticle Published on 2022-09-022022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] adaptive Adaptive immune response adaptive immune responses addition antibody antibody production B cells B-cell BCR component COVID-19 Critical develop effective flow cytometry immune immune protection immune response Infection Measures molecular mechanism natural infection offer pandemic Pathogenesis Protective recent receptor SARS-CoV-2 SARS-COV-2 infection severity single-cell single-cell analysis Support T cell T-cell receptor TCR the disease therapeutic intervention transcriptomics vaccination Vaccine variants [DOI] 10.3389/fimmu.2022.964976 PMC 바로가기
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다Article Published on 2022-07-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19 [DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
From COVID to fibrosis: lessons from single-cell analyses of the human lungCOVID에서 섬유증까지: 인간 폐의 단일 세포 분석에서 얻은 교훈Review Published on 2022-06-132022-09-11 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] alveolar cell Cell cell population cellular phenotype cellular phenotypes changes in complications COVID COVID-19 COVID-19 pneumonia disease epithelial Features fibrosis Fibrotic interstitial lung disease Gene Expression gene expression pattern gene expression patterns highlight highlighting human lung idiopathic Idiopathic pulmonary fibrosis implication Injury interstitial Interstitial lung disease Interstitial lung diseases IPF IPF cell atlas life-threatening lung Lung disease Lung diseases Macrophage mechanism monocyte-derived macrophage multiple tissue multiple tissues organs parenchymal pathologic condition Pneumonia populations pulmonary fibrosis single-cell analysis Single-cell RNA-sequencing viral disease [DOI] 10.1186/s40246-022-00393-0 PMC 바로가기 [Article Type] Review
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis면역 시공간 환경의 단일 세포 전사체 프로파일링은 다균성 패혈증에서 수지상 세포 조절 프로그램을 보여줍니다Article Published on 2022-05-292022-09-11 Journal: Theranostics [Category] 치료제, [키워드] activated adopted alteration Analysis applied available data Cancer canonical CD4 cDCs characterized co-cultured comprehensive view conserved COVID-19 patients Cytometry demonstrated dendritic dendritic cell dendritic cells described determined by dissect experiment experiments expression Flow flow cytometry generate Genes heterogeneity Host immune response hyperinflammation identify IFNGR2 immune Immune cell immune cell types immune cells immunofluorescence Immunosuppression indicated inhibitory initiated Intracellular majority maturation morbidity multiplex immunofluorescence myeloid cells naïve natural killer observation organ dysfunction pathway Pathways progression promoted protein level Puncture rationale Regulatory regulatory T cells reveal scRNA-seq ScRNA-seq analysis Sepsis septic septic patients signaling pathway single-cell single-cell analysis Single-cell RNA sequencing specific type staining STAT3 subset T cell T cells tissue tissue sites Transcriptome unique upregulation [DOI] 10.7150/thno.72760 PMC 바로가기 [Article Type] Article
An Imaging and Computational Algorithm for Efficient Identification and Quantification of Neutrophil Extracellular Traps호중구 세포외 트랩의 효율적인 식별 및 정량화를 위한 이미징 및 계산 알고리즘Article Published on 2022-01-062022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome Algorithm analyses Analysis Annexin Apoptosis approach Arthritis Asthma Cancer Cell cell death cellomics cells Combination COVID-19 death disease pathology DNA efficient eliminated ELISA ENhance exhibited extracellular trap fixation flow cytometry high content screening identification identify Image imaging immunoblotting impermeable inconsistency increase in Inflammation inhibitor intensities intensity lupus erythematosus Microscopy modulate morphology Multiple Necrosis NET NETosis NETs neutrophil Neutrophil extracellular traps Neutrophils nomenclature non-specific nuclear pathway platform provided quantification respiratory distress rheumatoid arthritis Sepsis single-cell single-cell analysis staining suffered syndrome systemic lupus erythematosus target Therapeutic approach therapeutic approaches [DOI] 10.3390/cells11020191 PMC 바로가기 [Article Type] Article