Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infectionArticle Published on 2023-03-312023-06-11 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] HBV Hi-C host-virus interaction Liver cancer single cell sequencing structural variation (SV) TAD and A/B compartments transposable element (TE). [DOI] 10.3389/fimmu.2023.1161522 PMC 바로가기
A cross entropy test allows quantitative statistical comparison of t-SNE and UMAP representationsArticle Published on 2023-01-132024-09-05 Journal: Cell Reports Methods [Category] update2024, [키워드] Dimensionality reduction flow cytometry mass cytometry single cell sequencing T-SNE UMAP [DOI] 10.1016/j.crmeth.2022.100390 PMC 바로가기 [Article Type] Article
Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolutionArticle Published on 2022-08-012023-08-30 Journal: Clinical and Translational Medicine [Category] E형 간염, [키워드] Crosstalk single cell sequencing [DOI] 10.1002/ctm2.886 PMC 바로가기
Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic ImplicationsReview Published on 2022-06-302023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] COVID-19 Immunotherapy Memory-like NK cells SARS-COV-2 infection single cell sequencing [DOI] 10.3389/fimmu.2022.888248 PMC 바로가기 [Article Type] Review
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617B.1.617에 대한 효능을 유지하는 단일특이성 및 이중특이성 단일클론 SARS-CoV-2 중화 항체Article Published on 2022-03-282022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibody B cell B cells B.1.617 B.1.617.2 binding patterns Breakthrough infection breakthrough infections caused clone complex conformations COVID-19 Critical cryo-EM structure cryo-EM structures death delta variant ectodomain Efficacy Epitopes expand facilitate functional generate humanized identify immunized in vivo inhibitory activity lead mAb mAbs maintain monoclonal monoclonal antibodies monoclonal antibody nanomolar affinity neutralize Neutralizing Neutralizing antibodies neutralizing antibody occur pathogen prefusion Prophylactic RBD Receptor binding domain repertoire SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants single cell sequencing Spike receptor binding domain spike trimer therapeutic therapeutic option Therapeutics translation Vaccine variants variants of concern virus [DOI] 10.1038/s41467-022-29288-3 PMC 바로가기 [Article Type] Article
Cell specific peripheral immune responses predict survival in critical COVID-19 patients세포 특이적 말초 면역 반응은 중요한 COVID-19 환자의 생존을 예측합니다Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Accuracy Activation antibody Antigen presentation Applied immunology Blood CD14 CD16 Cell cell cycle cell type cell types cells circulating Clinical management complex COVID-19 COVID-19 patients Critical critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients dataset Differential gene expression framework identify identifying Immune cell immune cell type independent Infection interferon interferon signaling machine mechanism monocyte Monocytes mononuclear cells Mortality NK-cell Pathogens pathway Peripheral blood peripheral immune response predict predictor prognostic indicator promote Regulation risk stratification SARS-CoV-2 sequence Single Cell single cell sequencing Single-cell RNA sequencing survival systemic immune response transcriptional transcriptomes transcriptomics Trigger triggers viral infection [DOI] 10.1038/s41467-022-28505-3 PMC 바로가기 [Article Type] Article
Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic dataArticle Published on 2022-01-192022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] advance Algorithm can be used Cancer cancer cell Cancer genomics Cell cell population cell type classical Computational models dataset defined estimate expression flexible Gene Expression granular heterogeneity identify immune immune response lung tumors mapping marker Proteins quantification Region resolved single cell sequencing Statistical methods tissue transcriptomic data transcriptomics tumors Tumour immunology [DOI] 10.1038/s41467-022-28020-5 PMC 바로가기 [Article Type] Article
Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors부인과 종양과 코비드 -19 회복기에서 면역 세포의 조성 및 기능에 대한 화학 요법 및 면역 요법의 영향Research Paper Published on 2021-12-152022-09-01 Journal: Aging (Albany NY) [Category] SARS, 진단, [키워드] acute infection anti-viral activity B cells cancers caused Chemotherapy clonal expansion convalescent Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CoVs effort ENhance facilitated functional phenotype healthy donor ICIs Immune cell immunological change Immunological memory Immunotherapy Impact molecular feature molecular features neutropenia NK cells pandemic Patient patients PBMC PBMCs performed Peripheral blood peripheral blood samples proportion PROTECT Reinfection resurgence SARS-CoV-2 virus single cell sequencing Single-cell RNA sequencing T and B cells T cell T cells Treatment Tumor tumors [DOI] 10.18632/aging.203739 PMC 바로가기 [Article Type] Research Paper
A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge ModelArticle Published on 2021-04-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal animal model antibody approach cellular fraction challenge clinical evaluation COVID-19 COVID-19 pandemic demonstration disease Diseases effective Efficacy flow cytometric hamster histopathological immune responses immune stimulation Immunological response Inactivated vaccine Inactivated virus vaccine Infection live SARS-CoV-2 many cases Model neutralizing antibody novel photochemical Prevent produced promote RBD Riboflavin SARS-CoV-2 SARS-CoV-2 virus single cell sequencing Spike protein spread of COVID-19 Th1 tissue utility UV light vaccination Vaccine vaccine candidate vaccine for COVID-19 vaccine production viral shedding virion [DOI] 10.3390/vaccines9040340 PMC 바로가기 [Article Type] Article
Single cell sequencing shines a light on malaria parasite relatedness in complex infectionsarticle Published on 2020-02-282024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] co-transmission complexity of infection (COI) malaria Relatedness single cell sequencing superinfection [Article Type] article