Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivityReview Published on 2024-02-062024-09-05 Journal: BMC Public Health [Category] update2024, [키워드] ASMase ceramide COVID-19 FIASMAs sphingomyelin [DOI] 10.1186/s12889-024-17747-z PMC 바로가기 [Article Type] Review
TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagyArticle Published on 2023-07-062024-09-05 Journal: The EMBO Journal [Category] update2024, [키워드] Autophagy & Cell Death CASM DysF membrane damage noncanonical autophagy sphingomyelin [DOI] 10.15252/embj.2022113105 PMC 바로가기 [Article Type] Article
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19Article Published on 2022-10-012022-11-15 Journal: Clinical and Translational Medicine [Category] 바이오마커, [키워드] Administered association biological properties Biomarker ceramide characteristic clinical phenotype conditions control subject coronavirus disease Course COVID-19 Critical CRP D-dimer decrease develop disease severity dynamic early phase glycerophospholipids heterogeneity heterogeneous Infectious disease Laboratory testing Lipidomics lysophosphatidylcholine mechanism mice modulation negative correlation Phosphatidylcholine positive Prevent responsible serum severe COVID-19 severity shown sphingolipid sphingolipids sphingomyelin subject subjects suppress tissue treated unsaturated [DOI] 10.1002/ctm2.1069 PMC 바로가기
Analysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesisArticle Published on 2022-03-012024-08-28 Journal: Journal of Cell Science [Category] 말라리아, [키워드] Gametocytes lipidome malaria Plasmodium falciparum sphingomyelin Transmission
Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic StrategiesImmunology Published on 2021-12-202022-10-04 Journal: Frontiers in Immunology [Category] SARS, 신약개발, [키워드] Activation adaptive Analysis anti-inflammatory agent benefit Biomarker cellular ceramide circulating circulation clinical phenotype Clinical studies Cohort Course COVID-19 Critically ill patient demonstrated Drug repurposing evaluate FDA-approved drugs FIASMA functional hallmark healthy controls independent inhibition intensive care intensive care patient lipoprotein membrane molecular biology of critical care molecular markers multicenter observational studies Organ failure pathophysiological pathway provide RBC red blood cell response SARS-COV-2 infection serum severe coronavirus disease severe COVID-19 SMPD1 sphingolipid sphingomyelin sphingomyelinase Strategy Stress subsequent Support the patient treatment strategy Trial with COVID-19 [DOI] 10.3389/fimmu.2021.784989 PMC 바로가기 [Article Type] Immunology
Link between serum lipid signature and prognostic factors in COVID-19 patientsCOVID-19 환자의 혈청 지질 특징과 예후 인자 사이의 연관성Article Published on 2021-11-042022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] (C-reactive protein) Affect affected age Analysis analyzed Biomarker C-reactive protein ceramide Coagulation COVID-19 COVID-19 patient COVID-19 patients creatinine Critical D-dimer Defense Disease progression disease progression and severity dyslipidemia Effect exhibited FIVE Horowitz hypoxia identify impairment index Inflammation Kidney function Lipid Lipidomics lipids MONITOR outcome outcomes oxidative stress Patient Prognostic factor Prognostic factors Prognostic markers reduced respiratory respiratory tract sera serum serum lipid Serum lipids severity sphingomyelin sphingomyelins sulfatide the disease the patient translation Viral viral infection [DOI] 10.1038/s41598-021-00755-z PMC 바로가기 [Article Type] Article
The acid sphingomyelinase/ceramide system in COVID-19COVID-19의 산성 스핑고미엘리나제/세라마이드 시스템Review Published on 2021-10-042022-09-10 Journal: Molecular Psychiatry [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] acid addition antibody antidepressants Antiviral approved blockade Cell cell entry ceramide cleave clinically Course COVID-19 Degradation Diseases downregulation drug Effect favorable effect Fluoxetine fluvoxamine form framework functional Genetic hydroxyzine Infection infection with SARS-CoV-2 inhibit inhibitor inhibitors lowering medication medications Molecular biology Neutral observational studies observational study Open-label plasma membrane platform Prospective Study provide Randomized repurposing restored SARS-CoV-2 sphingomyelin Support [DOI] 10.1038/s41380-021-01309-5 PMC 바로가기 [Article Type] Review
Severity of COVID-19 Patients Predicted by Serum Sphingolipids SignatureArticle Published on 2021-09-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acid sphingomyelinase analyzed Apoptosis AUC Biomarker calculated caspase 3 Cell ceramide Ceramides change characteristic characterized COVID-19 COVID-19 patient COVID-19 severity Critical critical patient decrease disease disease severity ELISA Evolution frailty GM3 healthy control in viral increase in indicated induce Infection influence inter-individual lipid metabolism mass spectrometry outcome palmitoyltransferase Patient patients Prognosis promoted Result ROC Curve SARS-COV-2 infection Serine serine palmitoyltransferase signature sphingolipid sphingolipids sphingomyelin sphingosine SPTLC1 subunit target Variability Viral load [DOI] 10.3390/ijms221910198 PMC 바로가기 [Article Type] Article
Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 PatientsMedicine Published on 2021-08-122022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] APACHE II AUC Biomarkers changes in chronic Cohort coronavirus disease COVID-19 COVID-19 case COVID-19 patient COVID-19 severity detection disease Duration Generalized linear model GLM help ICU ICU management ICU outcome identify IMV individual intensive care intensive care unit intubation Invasive mechanical ventilation LOS management Mechanical metabolite metabolomics Patient Pearson correlation Physiology predict predicted Predictive model Randomly selected serum sample sphingomyelin was performed was used [DOI] 10.3389/fmed.2021.733657 PMC 바로가기 [Article Type] Medicine
CERT L reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s diseaseResearch Published on 2021-02-172023-08-29 Journal: Alzheimer's Research & Therapy [Category] E형 간염, [키워드] 5xFAD Adeno-associated virus (AAV) Alzheimer’s disease (AD) Amyloid-β plaques ceramide Ceramide transporter protein (CERT) microglia Neuroinflammation sphingomyelin [DOI] 10.1186/s13195-021-00780-0 PMC 바로가기 [Article Type] Research