Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemicSARS-CoV-2의 스파이크 조각이 구피 포에실리아 망상체의 게놈 불안정성과 DNA 손상을 유발할 수 있습니까? COVID-19 전염병의 예상치 못한 영향Article Published on 2022-06-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] animals Brain Can catalase correlated COVID-19 COVID-19 pandemic demonstrated dismutase dispersal DNA damage ecosystem Effect ENA evaluate Frequency Freshwater fish gel electrophoresis genomic genotoxic genotoxicity Impact increase in induce knowledge lipid peroxidation liver malondialdehyde mutagenic Mutagenicity New coronavirus nuclear Olive Organisms parameter peptide peptides Protein raised reduction reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles significantly Single Cell Spike protein Superoxide Superoxide Dismutase tail the Spike Toxicity Viral particles water Water pollution [DOI] 10.1016/j.scitotenv.2022.153988 PMC 바로가기 [Article Type] Article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Total antioxidant capacity as a marker of severity of COVID-19 infection: Possible prognostic and therapeutic clinical applicationCOVID-19 감염의 중증도 마커로서의 총 항산화 용량 : 가능한 예후 및 치료 임상 적용Article Published on 2022-04-012022-08-31 Journal: Journal of medical virology [Category] 바이오마커, [키워드] activity antioxidant antioxidant enzyme blood sample Blood samples catalase causative pathogen collected Concentration control group COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Defense dismutase Enzymes healthy individual healthy individuals healthy volunteer infected individual infected individuals Infection investigated marker Mild Mild disease nitric oxide oxidative stress Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 Predictive prognostic Research SARS-COV-2 infection sera serum serum levels severe disease severely ill patients severity of COVID-19 statistically significant Superoxide Superoxide Dismutase susceptible TAC therapeutic Total total antioxidant capacity Variation was performed were measured with mild disease [DOI] 10.1002/jmv.27500 PMC 바로가기 [Article Type] Article
Resistance to artemisinin in falciparum malaria parasites: A redox-mediated phenomenonarticle Published on 2022-02-282024-09-01 Journal: Free Radical Biology and Medicine [Category] 말라리아, [키워드] antioxidant Artemisinin and Plasmodium GSH redox resistance Superoxide [Article Type] article
Mechanism of Caspase-1 Inhibition by Four Anti-inflammatory Drugs Used in COVID-19 TreatmentCOVID-19 치료에 사용되는 4가지 항염증제에 의한 Caspase-1 억제 메커니즘Article Published on 2022-02-062022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 치료제, [키워드] “cytokine storm” active site activity alleviate Amino acid analyzed anti-inflammatory drug Anti-inflammatory drugs antioxidant carbonyl caspase caspase-1 cause causes Colchicine Compound Computational methods Corticosteroid covalent bond COVID-19 COVID-19 infection COVID-19 therapy COVID-19 treatment cytokine cytokine release Cytokine storm Cytokines death Dexamethasone drug drugs effective excessive cytokine production help indicated Inflammatory Inflammatory response inhibition inhibitor mechanism Methylprednisolone molecular protease protons raloxifene reported residue scavenging Superoxide therapy these compounds transfer Treatment Trigger triggers [DOI] 10.3390/ijms23031849 PMC 바로가기 [Article Type] Article
Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19 †염증 세포의 부검 결과 및 치명적인 코로나19에서 4-하이드록시노넨알과 전신 혈관 및 산화 스트레스의 연관성 †Article Published on 2022-01-272022-09-11 Journal: Cells [Category] 바이오마커, 진단, [키워드] 4-hydroxynonenal 4-hydroxynonenal (4-HNE) absence acute tubular necrosis affected alveolar damage analyzed astrocytes Autopsy Biomarker Biomarkers blood vessel blood vessels Brain cells COVID-19 detrimental died differential expression Diffuse alveolar damage dismutase edema edematous finding Granulocytes immune system Immunohistochemical analysis Infection inflammatory cell inflammatory cells inflammatory parameters kidneys lethal leukocyte lipid peroxidation lung Lungs mitochondrial MPO myeloperoxidase nine organ organs oxidative burst oxidative stress Patient reactive reactive oxygen species (ROS) SAR-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Sepsis SOD2 Stress suggested Superoxide Superoxide Dismutase superoxide dismutase (SOD) survivor systemic the cells tissue Tubular Necrosis Vascular vascular stress [DOI] 10.3390/cells11030444 PMC 바로가기 [Article Type] Article
Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody InductionSuperoxide Dismutase는 SARS-CoV-2로 유도된 형질 세포 사멸을 방지하고 특정 항체 유도를 안정화시킵니다Research Article Published on 2022-01-172022-09-12 Journal: Oxidative Medicine and Cellular Longevity [Category] 진단, [키워드] administration alum alum adjuvant apoptotic cell count concurrent coronavirus disease CoV COVID-19 Culture Decline effective element generate heat stress immunization immunized induce induction Infection Maotai mice oxidative stress pathogenic plasma Plasma cell Plasma cells portion prevented promote promoted protein antigens reduced Safe SARS-CoV-2 spike protein Specific specific antibodies specific antibody Spike protein spleen Stress Superoxide treated [DOI] 10.1155/2022/5397733 PMC 바로가기 [Article Type] Research Article
Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 − Monocytes From COVID-19 PatientsCOVID-19 환자의 CD14 높은 CD16- 단핵구에서 지속적인 산화 스트레스 및 염증 활성화Immunology Published on 2022-01-142022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] addition caspase caspase-1 caused CD14 CD14highCD16− monocytes CD16 Cell contribute coronavirus coronavirus disease correlated COVID-19 dependent on disease severity displaying enrichment evidenced hallmark healthy controls hyperinflammation Hyperinflammatory IL-1β immunopathology implicated in vitro Inflammasome inflammasome activation lipid peroxidation Mild mitigate mitochondrial monocyte Monocytes NLRP3 NLRP3 inflammasome outcome outcomes oxidative oxidative stress oxidative stress response pathway Patient persistent response SARS-CoV-2 secretion severe COVID-19 patient severe COVID-19 patients signaling pathway Stress stress response stress responses Superoxide therapy [DOI] 10.3389/fimmu.2021.799558 PMC 바로가기 [Article Type] Immunology
The role of NADPH oxidases in infectious and inflammatory diseases감염성 및 염증성 질환에서 NADPH 산화효소의 역할Review Published on 2021-12-012022-09-12 Journal: Redox Biology [Category] MERS, SARS, 진단, [키워드] acute lung injury adaptive antigen processing Autoimmune disease Autoimmunity biological function caused Cell contribute COVID-19 diabete disease Donor DUOX1 DUOX2 enzyme epithelial expression free radical generate Human hydrogen peroxide Immunity implicated infection with SARS-CoV-2 Inflammasome inflammatory disease Innate immune defense involved lung molecular NADPH NADPH oxidase normal physiological processe NOx NOX2 oxidative stress oxygen pathology phagocytosis phosphate Regulation scavenging Seven Signaling Superoxide Superoxide. targeting therapy tissue type I interferons [DOI] 10.1016/j.redox.2021.102159 PMC 바로가기 [Article Type] Review
COVID-19: captures iron and generates reactive oxygen species to damage the human immune systemCOVID-19: 철분을 포획하고 반응성 산소종을 생성하여 인간 면역 체계를 손상시킵니다.Article Published on 2021-06-012022-09-11 Journal: Autoimmunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition adopted Antigen applied Asymptomatic asymptomatic infection attacked autophagy B cells bioinformatics Cell cell death complications Coronavirus pneumonia cytokine Cytokine storm damaged decrease destruction domain E protein Emergency envelope protein free radical generate Haemoglobin Human immune system hydrogen hydrogen peroxide hydrolase Hydrolases hydroxyl hydroxyl radicals hypoxia immune system infected cell infected cells inhibited iron lymphocyte Lymphocytes lymphopenia lysosome Macrophage mechanism membrane memory B cell memory B cells NK cell NK cells novel Novel coronavirus novel coronavirus pneumonia Organ failure oxygen pathogenic phagocyte phagocytes phagocytic cell phagocytic cells Pneumonia Previous studies previous study Re-infection reactive oxygen specy Reinfection released resulting ROS subsequent Superoxide superoxide anion superoxide anions surface antigen synthesised T cell T cells the patient tissue tissues Vesicle vesicles Viral viral infectivity virus viruses water while widespread [DOI] 10.1080/08916934.2021.1913581 PMC 바로가기 [Article Type] Article