Evolution of naturally arising SARS-CoV-2 defective interfering particlesArticle Published on 2022-10-272022-11-16 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] addition anti-viral agents arising can be used defective viral genome fusion protein gene delivery Genome identify Infection interfere multiplicity of infection parental Particle passaging of SARS-CoV-2 Replication SARS-CoV-2 selected synthetic the SARS-CoV-2 genome variant viral replication virus virus propagation [DOI] 10.1038/s42003-022-04058-5 PMC 바로가기
Twitter sentiment analysis: An Arabic text mining approach based on COVID-19Article Published on 2022-10-102022-11-16 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis approach Arabic changed country COVID-19 COVID-19 pandemic Culture dataset effort Express Facebook Government Gulf handling information Instagram Interaction machine learning machine learning - ML media mitigate natural language processing platform problem public health raw data reporter Research sentiment analysis (SA). social media social media platform social media platforms Spread spread of COVID-19 synthetic Synthetic Minority Over-sampling Technique (SMOTE) technique text text mining transmitted virus was done YouTube [DOI] 10.3389/fpubh.2022.966779 PMC 바로가기
Sticking – pulling strategy for assessment of combined medicine for management of tough symptoms in COVID-19 Pandemic using different windows of spectrophotometric Platform-Counterfeit products’ detectionResearch article Published on 2022-09-012022-10-05 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] 치료기술, [키워드] absorbance Absorbance difference (AD) ACE Aceclofenac AGREE amplitude Analysis analyzed approach calculated can be used complementary constant COVID-19 detect drug Extended Extended absorbance difference (EAD) Factorized derivative ratio null contribution (FDD- NC) in-silico index induced Induced dual amplitude difference (IDAD) linear management methodology Paracetamol physical platform Quality control Rabeprazole Spectral Spectral similarity index (SSI) SPS statistical Sticking Sticking - pulling strategy (SPS) Symptom synthetic Treatment window [DOI] 10.1016/j.saa.2022.121256 [Article Type] Research article
Handling class imbalance in COVID-19 chest X-ray images classification: Using SMOTE and weighted lossResearch article Published on 2022-08-012022-10-05 Journal: Applied Soft Computing [Category] 진단, 치료기술, [키워드] Accuracy assist AUC build Chest X-ray image Chest X-ray images claimed classification classifiers clinician CNNs COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 samples Data imbalance dataset datasets deep learning early diagnosis Efficiency examined hospitals Infection investigated Loss multi-classification positive patient Precision reduce selected sensitivity shown significantly specificity synthetic technique transfer transfer learning Viral pneumonia [DOI] 10.1016/j.asoc.2022.109588 [Article Type] Research article
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
Improved HPLC method for the determination of ribavirin concentration in red blood cells and its application in patients with COVID-19적혈구 내 리바비린 농도 측정을 위한 개선된 HPLC 방법 및 COVID-19 환자에 대한 적용Article Published on 2022-07-012022-09-11 Journal: Biomedical chromatography : BMC [Category] 치료제, [키워드] addition Adverse drug reactions Anemia antiviral drug Blood changes in Concentration correlation coefficient COVID-19 declined determine Efficacy erythrocyte hematocrit hematological parameter hematological parameters hemoglobin HPLC Improved Interim linear lowest Patient patients with COVID-19 phosphatase phosphorylated ranged red blood cell red blood cells ribavirin synthetic the patient [DOI] 10.1002/bmc.5370 PMC 바로가기 [Article Type] Article
Beyond Vaccination Rates: A Synthetic Random Proxy Metric of Total SARS-CoV-2 Immunity Seroprevalence in the Community예방 접종 비율을 넘어서: 지역 사회의 총 SARS-CoV-2 면역 혈청 유병률의 합성 무작위 프록시 메트릭Article Published on 2022-07-012022-09-12 Journal: Epidemiology (Cambridge, Mass.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjust Administered analyzed applied approach asymptomatic patient biologic clinical impact Community correlation country COVID-19 Critical dataset discrepancy driven by Effect expected Explicit knowledge hospital IgG immune Immune status Immunity Immunoglobulin IMPROVE incidence Infection limit magnitude metric Metrics mitigate natural infection naturally acquired immunity population immunity Prevalence random response SARS-CoV-2 Seroprevalence Surveillance symptomatic disease synthetic the disease the timing Total vaccination vaccination rate Vaccine Vaccine-induced immunity [DOI] 10.1097/EDE.0000000000001488 PMC 바로가기 [Article Type] Article
SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World’s PopulationSM-COLSARSPROT: 전 세계 인구를 대상으로 하는 고 면역원성 초돌연변이 합성 펩타이드Article Published on 2022-05-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid Antibody titre Antigen presentation approach backbone complementary concerning Coverage Covering disrupting DNA E protein genetic variability Genetic variant genotyped histocompatibility complex human leukocyte antigen immune response induce Interaction leukocyte major histocompatibility complex methodology MHCII modified synthetic peptides molecular multiepitope mutant mutational variants Neutralising Antibodies neutralising antibody pandemic parental peptide peptides physicochemical polymorphism Population predicted replacing residues SARS-CoV-2 SARS-CoV-2 S selected Specific Structure supramutational synthesised synthetic synthetic peptides Trial Vaccine development vaccine for COVID-19 virus worldwide coverage. π-π interaction [DOI] 10.3389/fimmu.2022.859905 PMC 바로가기 [Article Type] Article
Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제에 대한 잠재적인 항바이러스제로서의 합성 플라보노이드Article Published on 2022-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3-benzyloxyflavones 3-O-flavonol glycosides antiviral agent antiviral drug antiviral drugs binding binding affinity binding free energy catalytic dyad causative agent claimed complex Compound computational studies Computational study conserved COVID-19 COVID-19 pandemic crystal structure demonstrated docking Drug discovery effective facilitated filtered flavonoids flavonols free energy Free energy calculations healthcare providers in silico In silico methods in-silico Infection inhibit inhibitor Interaction iterative M pro molecular molecular docking molecules oxoaurones Panic performed protease protein-ligand reproduction residue resulting SARS-CoV-2 SARS-CoV-2 main protease stability substrate binding site synthetic targeting thioaurones thioflavonols. Treatment treatment of COVID-19 unavailability Vaccine Virtual screening [DOI] 10.1080/07391102.2020.1850359 PMC 바로가기 [Article Type] Article
Peptide-based simple detection of SARS-CoV-2 with electrochemical readout전기화학적 판독으로 SARS-CoV-2의 펩티드 기반 단순 검출Article Published on 2022-05-012022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus antigens approaches caused complex coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 detect followed by gold impedance Impedimetric biosensor infected patient infected patients Infectious disease Interaction limit of detection lysed nanomaterials outbreak pandemic path peptide platform Protein reported reproducibility respiratory SARS-CoV-2 SARS-CoV-2 particles SARS-CoV-2 spike protein Screen sensitivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 simplicity Spectroscopy spike Spike protein synthetic synthetic peptide tested the Spike virus [DOI] 10.1016/j.aca.2022.339739 PMC 바로가기 [Article Type] Article