Discovering potential interactions between rare diseases and COVID-19 by combining mechanistic models of viral infection with statistical modeling바이러스 감염의 기계론적 모델과 통계적 모델링을 결합하여 희귀 질환과 COVID-19 간의 잠재적 상호 작용 발견Article Published on 2022-06-222022-09-11 Journal: Human molecular genetics [Category] 유전자 메커니즘, 치료기술, [키워드] analyzed approach consequence Consequences coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 disease COVID-19 infection demonstrated described detect disease downstream genetic component genetic variability hallmark host genetics identify in some infection process Interaction loss of function mathematical mechanism molecular Molecular Disease MOST occur pathological consequences preventive measure Prognosis rare disease rare diseases recent statistical systematic analysis viral infection with COVID-19 [DOI] 10.1093/hmg/ddac007 PMC 바로가기 [Article Type] Article
Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variantsSARS-CoV-2 알파, 델타 및 오미크론 변이체의 스파이크 단백질에서 RBD에 대한 돌연변이 평가Article Published on 2022-05-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] accelerated ACE2 acute respiratory syndrome affinity angiotensin antibody resistance Arg assessment binding binding affinity charged residue conformational coronavirus correlated Critical Delta domain evaluate faster free energy Free energy calculation Free energy calculations human ACE2 receptor human Angiotensin-converting enzyme Impact Interaction molecular molecular dynamics Mutation occur omicron other variant other variants Protein provided RBD receptor residue S protein S protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus Severe acute respiratory syndrome spike Spike protein spike protein RBD Spread systematic analysis T478K the RBD the SARS-CoV-2 the Spike variant variants [DOI] 10.1038/s41598-022-12479-9 PMC 바로가기 [Article Type] Article
Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant오미크론 변이체에서 스파이크 단백질의 수용체 결합 도메인과 인간 안지오텐신 전환 효소-2 간의 결합 상호작용Article Published on 2022-05-052022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Affect angiotensin Antibody neutralization bind conformational changes contagious COVID-19 pandemic decrease distribution electrostatic interactions exacerbated Human K417N molecular molecular dynamics Mutation mutations N501Y new SARS-CoV-2 omicron Other predicted RBD RBD mutation Receptor-binding domain resulting S-protein spike Spike protein Strains systematic analysis T478K the receptor-binding domain the spike protein Transmissibility variant [DOI] 10.1021/acs.jpclett.2c00423 PMC 바로가기 [Article Type] Article
Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis백신 이전 시대의 연령별, 시기별, 지역별 코로나19 감염-치명률 변화: 체계적 분석Article Published on 2022-04-162022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] a metric accounted adjusted African age age distribution Analysis Asian baseline Bayesian Care caused Clinical practice comorbid condition comorbid conditions country covariate covariates COVID-19 COVID-19 disease COVID-19 mortality death decrease determinant determinants disease Diseases distribution effort elevated estimate Evolution excluded exclusion criteria Factor foundation Geography Greece group health system health-care health-care system help heterogeneity Hierarchical highest hotspot identify IFR implication in some include indicate individual infections Infectious diseases interquartile range Intervention introduced Japan likelihood Local location lowest measure median Melinda Gate Melinda Gates meta-regression metric Mortality mortality rate mortality risk Moss obesity observation occurred Oman outbreak parameter pathogen physical distancing measures Population population prevalence Portugal post-hoc analysis Potential predictor Prevalence progression provide Regression reported Research resulting risk risk stratification SARS-CoV-2 virus sensitivity Seroprevalence seroprevalence survey Seven severe cases severity of COVID-19 Spain systematic analysis the disease the median the SARS-CoV-2 virus Transmission treatment for COVID-19 understanding USA Vaccine variants Variation widespread with COVID-19 [DOI] 10.1016/S0140-6736(21)02867-1 PMC 바로가기 [Article Type] Article
Abnormal global alternative RNA splicing in COVID-19 patientsCOVID-19 환자의 비정상적인 글로벌 대체 RNA 스플라이싱Article Published on 2022-04-142022-09-11 Journal: PLoS Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affecting Alter Analysis antiviral immunity Blood coagulation CD74 changes in Clinical severity contribute correlated COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients cytokine production disrupt domain down-regulated dysregulation ExoN expression functional highlight Host host transcriptome induce Infection Intensive LRRFIP1 neutrophil neutrophil activation proteomic reduced RNA splicing SARS-CoV-2 SARS-COV-2 infection sequencing data severe COVID-19 patient severe COVID-19 patients systematic analysis therapeutic activity therapy transcript Transcriptome transcriptome analysis transcriptomic transcripts viral infections widespread [DOI] 10.1371/journal.pgen.1010137 PMC 바로가기 [Article Type] Article
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients조합 분석은 경증 COVID-19 환자에서 나중에 항바이러스 면역을 예측하는 고도로 조정된 초기 단계 면역 반응을 보여줍니다Article Published on 2022-03-292022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] Analysis antibody antibody levels Antibody Response antibody-secreting cell antibody-secreting cells antiviral immunity Arm Asymptomatic CD4 CD8 T cells cellular Cohort combinatorial analysis controls COVID-19 CXCL10 cytokine cytokine response dendritic cell Diagnosis dominant early-stage response expression feature Frequency functional hospitalized patient hospitalized patients immune immune cells immune reaction immune response immune responses immunology immunopathology Inclusion innate immune cell Innate immune cells interferon IP10 marker Mild mild COVID-19 patient mild COVID-19 patients mild patient mild patients non-hospitalized observé Patient PCR predict predict antibody levels Predictive remained response reveal SARS-CoV-2 severe COVID-19 systematic analysis systems immunology T cell T cells trajectory transient cytokine response. while [DOI] 10.1016/j.xcrm.2022.100600 PMC 바로가기 [Article Type] Article
Sentiment analysis and topic modeling for COVID-19 vaccine discussionsArticle Published on 2022-02-252022-10-29 Journal: World Wide Web [Category] COVID-19, [키워드] Analysis approved coronavirus country COVID-19 COVID-19 vaccine Data visualization deaths delta variant effective Effectiveness emotional Government IMPROVE in-depth analysis information language media natural novel coronavirus disease outbreak pandemic Perspective processing risk sentiment analysis Side effects social media platform social media platforms Support systematic analysis the vaccine Topic topic modeling Vaccine WHO World Health Organization [DOI] 10.1007/s11280-022-01029-y PMC 바로가기 [Article Type] Article
High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein스파이크 단백질을 넘어 SARS-CoV-2의 게놈 전체 분석에 의해 밝혀진 국가 간 Delta 변이체의 높은 다양성Article Published on 2022-02-142022-09-10 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha variant Amino acid Analysis Beta Bioinformatics analysis contagious coronavirus country Delta delta variant dominant feature focus genomes highlight identify life list Microbiology, Virology & Host Pathogen Interaction Missense mutation Mutation mutations neutralization nucleocapsid other variant other variants pathogenic performed Prevalence prevalent prevalent strain Protein Proteins proteome public health reduced SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 genomes SARS‐CoV‐2 protein SARS‐CoV‐2 proteins SARS‐CoV‐2 spike Spike protein susceptibility systematic analysis the Spike Transmissibility Vaccines Viral viral loads while [DOI] 10.15252/msb.202110673 PMC 바로가기 [Article Type] Article
Systematic molecular evolution enables robust biomolecule discovery Research Published on 2021-12-302022-10-05 Journal: Nature methods [Category] 변종, [키워드] adjust automated change changes Evolution Factor IMPROVE Laboratory molecular occur outcomes Protein random reliability RNA robust selective pressure systematic analysis the timing Variation [DOI] 10.1038/s41592-021-01348-4 [Article Type] Research
An Investigation into Art Therapy Aided Health and Well-Being Research: A 75-Year Bibliometric AnalysisArticle Published on 2021-12-262022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] addition Adolescent Analysis art therapy bibliometric analysis Cancer children co-occurrence co-occurrence analysis coronavirus disease COVID-19 Dementia Depression disease Diseases elderly Health Health and well-being investigation limitations mental health Palliative care Perspective physical Population promote provide psychological Impact psychotherapy Quantitative Research Schizophrenia systematic analysis therapeutic therapeutic effect therapeutic method therapy trauma virtual reality [DOI] 10.3390/ijerph19010232 PMC 바로가기 [Article Type] Article