Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in MacaquesArticle Published on 2024-03-012024-09-05 Journal: bioRxiv [Category] update2024, [키워드] antibodies compartment-specific immunity correlates of protection effector function Natural killer cells neutralization omicron SARS-CoV-2 systems immunology Vaccines [DOI] 10.1101/2024.03.01.582951 PMC 바로가기 [Article Type] Article
Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humansArticle Published on 2024-01-302024-09-05 Journal: Cell Reports [Category] update2024, [키워드] antiviral immunity conserved host response to viruses human immune response macaques non-human primates systems immunology transcriptomics virus [DOI] 10.1016/j.celrep.2024.113706 PMC 바로가기 [Article Type] Article
Using the power of innate immunoprofiling to understand vaccine design, infection, and immunityReview Published on 2023-10-262024-09-05 Journal: Human vaccines & immunotherapeutics [Category] update2024, [키워드] bioinformatics CyTOF GWAS Infectious disease Innate immune cells innate immune profiling Luminex mesoscale metabolomics MIBI Multi-color flow cytometry multiplex cytokine profiling O-Link phospho-flow RNA sequencing systems immunology vaccinology [DOI] 10.1080/21645515.2023.2267295 PMC 바로가기 [Article Type] Review
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patientsarticle Published on 2023-05-232024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] COVID-19 Immunophenotyping longitudinal modeling Multi-omics SARS-CoV-2 systems immunology [DOI] 10.1016/j.xcrm.2023.101079 PMC 바로가기 [Article Type] article
Metabolomics meets systems immunologyReviews Published on 2023-03-142024-09-05 Journal: EMBO Reports [Category] update2024, [키워드] Computational biology immunology Infection metabolism metabolomics multiomics statistical analysis systems immunology [DOI] 10.15252/embr.202255747 PMC 바로가기 [Article Type] Reviews
Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severityResearch Article Published on 2023-01-132024-09-05 Journal: Journal of medical virology [Category] update2024, [키워드] cell cycle associated molecules COVID‐19 severity proteomics SARS‐CoV‐2 systems immunology transcriptomics [DOI] 10.1002/jmv.28450 PMC 바로가기 [Article Type] Research Article
Macrophage Boolean networks in the time of SARS-CoV-2Article Published on 2022-10-172023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Boolean models COVID-19 gene regulatory network Macrophage SARS-CoV-2 systems immunology [DOI] 10.3389/fimmu.2022.997434 PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종Article Published on 2022-08-022022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology Transcriptome triplex vaccination vaccination schedule vaccine candidate [DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activationArticle Published on 2022-06-282023-07-09 Journal: Cell Reports [Category] COVID19(2023년), [키워드] CP: Immunology Cytokine variability IL-12p70 systems immunology TLR4 immune responses type I interferons [DOI] 10.1016/j.celrep.2022.110989 PMC 바로가기