Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19: A randomized placebo-controlled trialResearch article Published on 2022-08-012022-10-05 Journal: Asian Journal of Urology [Category] 임상, [키워드] acute respiratory distress administration baseline caused Complete complete recovery control group coronavirus disease COVID-19 criteria Daily dysfunction effective Efficacy Erectile dysfunction function Health index intervention group men objective Outpatient Patient Placebo polymerase chain Prevalence questionnaire randomized placebo-controlled trial Result risk Safe Sexual function significantly higher subsequent syndrome Tadalafil the patient Treatment was performed [DOI] 10.1016/j.ajur.2022.05.006 [Article Type] Research article
The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Micearticle Published on 2022-05-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] Gametocytes humanized mice phosphodiesterase Plasmodium falciparum Tadalafil Transmission [Article Type] article
Data mining methodology for response to hypertension symptomology—application to COVID-19-related pharmacovigilance고혈압 증상에 대한 데이터 마이닝 방법론 - COVID-19 관련 약물 감시에 적용Research Article Published on 2021-11-232022-09-10 Journal: eLife [Category] MERS, SARS, 치료기술, [키워드] acting acute respiratory illness ADE ADEs Adverse Affect affecting angiotensin Antihypertensive drug antihypertensive drugs Antithrombotic artificial intelligence association beraprost blockers blood pressure bosentan build calcium calcium channel calcium channel blockers candesartan Cluster Combination confounding factor confounding factors coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related pharmacovigilance data-driven methodology demographics disease Disease prevalence distribution doxazosin drug drugs effective endothelin receptor antagonist Endothelin receptor antagonists Epoprostenol evaluated exhibited Factor FDA FDA ADE database feature filtered Friedman test funding geometric geometric mean group had no hidden high risk highest hypertension Hypothesis incidence limit macitentan medication medications meta-analyses Meta-analysis methodology monotherapy Nifedipine None operator outcome Patient patients pharmacovigilance Potential potential therapy profile Pulmonary function pulmonary symptomology Quantitative randomized clinical trials Renin renin-angiotensin system reported Reporting respiratory Respiratory illness retrieved rilmenidine selected drug selected drugs selexipag shown Side effect significant difference significant differences significantly higher Sildenafil Stage Tadalafil Therapeutics therapy [DOI] 10.7554/eLife.70734 PMC 바로가기 [Article Type] Research Article
Virtual screening, molecular dynamics and structure-activity relationship studies to identify potent approved drugs for Covid-19 treatmentCOVID-19 치료를위한 강력한 승인 약물을 확인하기위한 가상 스크리닝, 분자 역학 및 구조-활성 관계 연구Article Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] Accuracy active site applied approach approved approved drug approved drugs best binding energy binding energy prediction binding free energy binding site Bromocriptine candidate complexes COVID-19 COVID-19 treatment Cys145 determined by dominant drug drug design Drug screening drugs Ergotamine facilitate FDA FDA approved drug food free energies His41 hydrogen hydrogen bonding hydrophobic hydrophobic interactions identify Interaction MD simulation MD simulations MLR MM/PBSA molecular molecular docking molecular dynamics MPro Multiple linear regression offer Pattern recognition performed predicted Principal component principal component analysis protease Protein Quantitative receptor residues SAR SARS-CoV-2 SARS-CoV-2 main protease selected drug selected drugs Simeprevir similarity stability structural–activity relationship. Tadalafil the SARS-CoV-2 Treatment [DOI] 10.1080/07391102.2020.1794974 PMC 바로가기 [Article Type] Article
Bioequivalence and food effect of a fixed-dose combination of macitentan and tadalafil: Adaptive design in the COVID-19 pandemicClinical Trial Published on 2021-10-012022-10-05 Journal: Pharmacology Research & Perspectives [Category] 임상, [키워드] adaptive AUC Bioequivalence C max CIs clinical study clinically Combination condition conditions conducted confidence interval COVID-19 pandemic enrolled evaluated fasted fed fixed-dose combination food effect geometric mean ratio GMR GMRs healthy subjects limit limitations limits macitentan Open-label pharmacokinetic Phase 1 plasma concentration pulmonary arterial hypertension Randomized safety profile Serious Adverse Event significant difference single-center Study design subject subjects Tablet Tadalafil tadalafil. treatment groups was determined [DOI] 10.1002/prp2.846 PMC 바로가기 [Article Type] Clinical Trial
Targeting the SARS-CoV-2 3CL pro and NO/cGMP/PDE5 pathway in COVID-19: a commentary on PDE5 inhibitorsCommentary Published on 2021-02-122022-10-31 Journal: Future Cardiology [Category] COVID-19, MERS, SARS, [키워드] 3CL pro 3CLpro COVID-19 NO/cGMP pathway PDE5 PDE5 inhibitor PDE5 inhibitors SARS-CoV-2 Sildenafil Tadalafil targeting the SARS-CoV-2 Thromboembolism [DOI] 10.2217/fca-2020-0201 PMC 바로가기 [Article Type] Commentary
Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection?Review Published on 2021-01-012022-10-04 Journal: Sexual medicine reviews [Category] 신약개발, [키워드] acute respiratory distress addition adjuvant Anti-inflammatory antiapoptotic antioxidant Apoptosis CINAHL Clinical efficacy Cochrane Library combating contribute coronavirus disease COVID-19 COVID-19 infection COVID-19 pathology curative cytokine database demonstrated distress drug drugs dysfunction Effect enzyme exaggerated immune response Google Scholar Healthcare system Hydrogen sulfide immune response implication Inflammation inhibitor literature review lung Manifestations monophosphate offer oral outbreak pandemic pathway Pathways patients with COVID-19 PDE5 inhibitor PDE5 inhibitors phosphodiesterase Potential protocol provided public health emergency Regulation role SARS-CoV-2 Sildenafil Support Tadalafil Treatment Vaccine Vardenafil Vardenafil. was performed while worsening [DOI] 10.1016/j.sxmr.2020.08.006 PMC 바로가기 [Article Type] Review
Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approachArticle Published on 2020-11-052022-10-04 Journal: Scientific Reports [Category] 신약개발, 임상, 진단, 치료제, [키워드] 3CLpro active against addition adopted approach AutoDock baloxavir marboxil bind binding binding affinity binding energy binding free energy clinical trial Compound coronavirus crystal structure darunavir database death dihydroergotamine Drug discovery drug trials drugs healthcare help homology host cell identify Infection inhibit lack Lonafarnib Medicinal chemistry molecular Nilotinib outbreak pandemic Papain-like protease phthalocyanine PLPro protease Protein RdRP reached reported Research RNA-dependent RNA polymerase SARS-CoV-2 screened Spike protein Spread Structure Tadalafil target targets Theoretical chemistry these compounds Treatment viral infection virus [DOI] 10.1038/s41598-020-75762-7 PMC 바로가기 [Article Type] Article
Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods: The Case of Milbemycin, Ivermectin, and Baloxavir MarboxilShort Communication Published on 2020-01-012022-10-28 Journal: Avicenna Journal of Medical Biotechnology [Category] COVID-19, [키워드] Antiviral agents baloxavir baloxavir marboxil binding activity clinical trial COVID-19 Dependent docking drug drugs effective global pandemic high affinity highest binding affinity inhibitor Ivermectin Laboratory Milbemycin new virus RdRP respiratory RNA SARS-CoV-2 Tadalafil the disease the SARS-CoV-2 Treatment Vaccine Viral RNA PMC 바로가기 [Article Type] Short Communication
Advice for travelersArticle Published on 2019-10-072024-08-28 Journal: Med Lett Drugs Ther [Category] 말라리아, [키워드] acetazolamide Adalat adverse effects Aemcolo Alertec altitude illness Ambien Antihistamines Arakoda armodafinil atovaquone/proguanil Azithromycin bismuth subsalicylate Bonamine Ceralyte Chikungunya Chloroquine Cialis Cipro ciprofloxacin Decadron Deep vein thrombosis DEET Dengue Dengvaxia Dexamethasone dimenhydrinate dosage doxycycline Dramamine Duranon DVT Efficacy Escherichia coli fluoroquinolones Gastrolyte Gravol Hetlioz Histanil ibuprofen Imodium insect bites insect repellents Insomnia jet lag ketoconazole Krintafel leptospirosis Levaquin levofloxacin loperamide malaria malarone meclizine mefloquine melatonin modafinil motion sickness Nifedipine Nuvigil ofloxacin ORS Pepto-Bismol Permanone Permethrin Phenergan Pregnancy primaquine Procardia Promethazine Provigil ramelteon rifamycin rifaximin Rozerem Safety Scopolamine Sublinox sunburn sunscreens Tadalafil tafenoquine tasimelteon Transderm Scop Transderm V Travel Travelers' diarrhea Vaccines Venous Thromboembolism Vibramycin Xifaxan Zaxine Zika Zithromax zolpidem.