A pseudovirus-based platform to measure neutralizing antibodies in Mexico using SARS-CoV-2 as proof-of-conceptArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Accuracy antiviral immune response applied BSL-2 BSL-3 BSL-3 facilities evaluate evidenced functional in vitro Infection information Latin lentiviral particles Live virus Luminescence methodology NAb NAbs neutralizing antibody non-replicative Particle pathogen performed platform Protein pseudotyped lentiviral particles pseudovirus reporter resource Safe SARS-CoV-2 selected sensitivity serum samples specificity target cell transduced viral pathogen [DOI] 10.1038/s41598-022-22921-7 PMC 바로가기
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019Article Published on 2022-10-172022-11-16 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome alkaline Anosmia cause Cell coronavirus COVID-19 D614G D614G mutation Efficiency Express expressing host cell hydrophobic less Loss of Smell Mucus Mutation olfactory dysfunction Olfactory epithelium olfactory function omicron Omicron variant penetration potential mechanism Prevalence Receptor binding reduce reduced SARS-CoV-2 Support target cell tissue tropism TMPRSS2 transmembrane serine protease variants [DOI] 10.1093/infdis/jiac113 PMC 바로가기
The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognitionArticle Published on 2022-09-212022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] Affect Analysis Antigen antigen processing Antiviral antiviral activity CD8 Cell Cellular immune response delta variant epitope Ex vivo Express in vitro in vitro result inhibitor Mutation N-terminus neutralizing antibody omicron Protein Replication SARS-CoV-2 SARS-CoV-2 variant suppress susceptibility T cell T cells T-cell target cell TCR the SARS-CoV-2 virus treated variant variants [DOI] 10.1038/s41467-022-33068-4 PMC 바로가기
Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2Article Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 expression Affect antibodies antibody Cell cell receptor domain Effectiveness expression Infection lentivirus Level monoclonal monoclonal antibody N-terminal domain neutralization Neutralization assay neutralize Neutralizing activity neutralizing antibody neutralizing antibody epitopes NTD polyclonal antibody polyclonal human sera pseudovirus Pseudovirus neutralization assays RBD Region SARS-CoV-2 Serum Neutralization spike epitope subset target target cell target cell receptor expression. target cells the RBD therapeutic [DOI] 10.3390/v14092061 PMC 바로가기
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy PathogenesisArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 acute respiratory distress alveolar angiotensin-converting enzyme 2 binding blocked Blood coagulation Capillaries cell types cellular co-culture Coagulopathy communication Contact COVID-19 COVID-19 patient Delta Disease progression drug DTNB endothelial Endothelial cell endotheliopathy Evidence Express expression extrinsic pathway Factor Factor-V fibrinogen functional groups had no Human human lung human lung endothelial cells humans induce infect inhibited inhibitor interactions investigated leukocyte mechanism Microvascular thrombosis neutrophil Neutrophils Pathogenesis pathway Patient potential mechanisms prevented Protein pulmonary complication Pulmonary endothelium recombinant S-protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 variant SARS-CoV-2 virion secretion severe lung injury significantly increased spike syndrome target cell TFPI therapeutic strategy thrombin thrombomodulin thrombosis tissue Tissue Factor Transcriptional upregulation vascular endothelial cell vessel Wuhan [DOI] 10.3390/ijms231810436 PMC 바로가기
SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodiesSARS-CoV-2 Omicron 하위 계통은 유사한 세포 진입을 나타내지만 치료 항체에 의한 차등 중화를 나타냅니다.Article Published on 2022-08-102022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody-mediated neutralization BNT162b2 booster vaccination cell entry cilgavimab comparable COVID-19 COVID-19 therapy Efficiency eight evade exhibit FUSE homologous or heterologous neutralization neutralized omicron Omicron variant SARS-CoV-2 Seven Sotrovimab spike susceptibility target cell target cells therapeutic therapeutic antibodies therapy Transmissibility Treatment vaccination Vaccine vaccine-induced antibodies vaccine-induced antibody variant of SARS-CoV-2 [DOI] 10.1016/j.chom.2022.04.017 PMC 바로가기 [Article Type] Article
Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped virusesArticle Published on 2022-08-012022-11-15 Journal: Phytotherapy research : PTR [Category] SARS, 치료제, [키워드] ACE2 receptor ADA Antiviral antiviral activity antivirals antivirals. approach blocked caused complementary COVID-19 pandemic death drug candidate effective drugs evaluated H5N1 HIV-1 Host indicated inhibited inhibitor inhibitory activity plant pseudotyped pseudovirus responsible Safe SARS-CoV-1 SARS-CoV-1 and 2 SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoVs Spatholobus suberectus Dunn target cell Toxicity treating COVID-19 Treatment viral entry virus viruses [DOI] 10.1002/ptr.7452 PMC 바로가기
The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor녹차 카테킨 EGCG는 범 코로나바이러스 부착 억제제에 대한 개념 증명을 제공합니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity attachment block catechin caused Cell conserved coronavirus Coronavirus-2 Coronaviruses CoV CoV infection COVID-19 pandemic CoVs EGCG Endemic epigallocatechin epigallocatechin gallate epithelial cells gallate glycans green tea HCoV-OC43 Health heparan sulfate heparin highlight highly pathogenic CoVs Infection inhibitor inhibitors Lentiviral particle lentiviral particles Lung epithelial cells mechanism murine Prevent PROTECT Proteoglycan provide pseudotyped rapid response reduce remained required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spike protein Spike proteins sulfate target cell Treatment Vaccine development virion binding virus [DOI] 10.1038/s41598-022-17088-0 PMC 바로가기 [Article Type] Article
The clinical progress of mRNA vaccines and immunotherapies Reviews Published on 2022-05-092022-10-05 Journal: Nature biotechnology [Category] 임상, [키워드] acute respiratory syndrome addition administration booster building Cancer cellular coronavirus coronavirus disease COVID-19 doses drugs effective Emergency use authorization Epstein–Barr virus highlight HIV Human immunodeficiency virus immune stimulation immunostimulatory Immunotherapy Infectious disease inherent Local MOST mRNA mRNA vaccine mRNA-based nucleic acid Protein protein expression repeated Seasonal influenza sequence target cell therapy tissues translation Vaccine Vaccines [DOI] 10.1038/s41587-022-01294-2 [Article Type] Reviews
The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19Review article Published on 2022-04-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Affect cardiac damage cardiovascular cardiovascular complication cardiovascular complications Cardiovascular function cause Cell cells cellular chemokine Comorbidity contribute coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm disorder evaluated expressed fibroblasts function immune Immune cell immunological mechanism IMPROVE infect Inflammation Inflammatory cytokine Inflammatory responses macrophages mechanism mechanisms molecular Monocytes Patient pericytes reducing regulate Regulatory T cell Research risk SARS Coronavirus SARS CoV-2 severe COVID-19 subset suppress T cell target cell therapeutic potential These cells Treatment Treg Tregs variety viral infection [DOI] 10.1016/j.lfs.2022.120392 [Article Type] Review article