Short telomeres in alveolar type II cells associate with lung fibrosis in post COVID-19 patients with cancerResearch Paper Published on 2023-06-152024-09-05 Journal: Aging (Albany NY) [Category] update2024, [키워드] ATII cells COVID-19 Lung fibrosis SARS-CoV2 telomeres [DOI] 10.18632/aging.204755 PMC 바로가기 [Article Type] Research Paper
Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review
SARS-CoV-2 triggers DNA damage response in Vero E6 cellsArticle Published on 2021-09-152023-06-16 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, [키워드] DNA damage response Genome instability SARS-CoV-2 telomeres [DOI] 10.1016/j.bbrc.2021.09.024 PMC 바로가기 [Article Type] Article
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 SurvivorsCOVID-19 생존자의 생물학적 연령 가속 및 텔로미어 단축에 대한 증거Hypothesis Published on 2021-06-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] acceleration ACE2 ACE2 expression age age determination alteration analyzed Biological biological age characterized Cohort COVID-19 CpG cytokine death defined DeltaAge determine difficulty DIFFICULTY CONCENTRATING DNA methylation DPP-4 Dyspnea Epigenetic epigenetics fatigue fibrosis Immunosuppression increase in Inflammatory cytokine memory memory loss non-infected normality post-COVID-19 Post-COVID-19 patients PPCs pyrosequencing respiratory distress SARS-COV-2 infection Severe respiratory distress shortening sleep disorders subject survivor Survivors syndrome telomere telomeres Volunteer world population younger patient younger patients [DOI] 10.3390/ijms22116151 PMC 바로가기 [Article Type] Hypothesis
Shorter telomere lengths in patients with severe COVID-19 disease중증 코로나19 환자의 텔로미어 길이 감소Research Paper Published on 2021-01-152022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] age aging Cell cell types chromosome contribute COVID-19 COVID-19 patient disease higher risk highest impair incidence increase individual infect limit Lymphocytes maintain manifestation mechanism molecular Mortality older patient older patients Pathologies pathway Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Protective regeneration regenerative SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severe COVID-19 disease severe manifestations of COVID-19 severity severity of COVID-19 Structure telomere telomeres the disease tissue tissue homeostasis tissues Trigger [DOI] 10.18632/aging.202463 PMC 바로가기 [Article Type] Research Paper
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesisReview article Published on 2020-09-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 유전자 메커니즘, [키워드] addition adenine Affect Ageing alteration antigen-presenting cell biological function Cellular immune response change chromosome circulating pro-inflammatory cytokine Complication COVID 19 COVID-19 COVID-19 patient Cytokine storm death dinucleotide Effects elderly Factor Gas exchange Hospitalization Hypothesis immune Immune cell immune function immune system immunomodulator impairment increase in Increasing influence inhibitory effect lung lymphocyte morbidity and mortality NAD+ positive Prevent pro-inflammatory cytokine Respiratory function risk sensitivity Severe infection stability susceptibility telomere telomeres [DOI] 10.1016/j.jiph.2020.06.004 [Article Type] Review article
Endogenization and excision of human herpesvirus 6 in human genomes인간 게놈에서 인간 헤르페스바이러스 6의 내생성 및 절제Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting association childhood chromosome chromosome 22q chromosomes contribute described direct repeats Diseases DRs East Asians Evolution excision expected explain Genome genome sequence Genome sequences germline germlines HHV-6 HHV-6A HHV-6B homologous Human Human genome Human genomes human herpesvirus 6 humans in vivo infect Infectious virus integration Japan Japanese Japanese people leads life locus MOST MOV10L1 nuclear physically PIWI-interacting RNAs polymorphism Polymorphisms question raise Reactivation Recombination reported required risk RNA screened sequence sequences solo-DR subject subtelomere telomere telomeres transposons variant Viral viral genome viral reactivation virus WGS whole-genome sequencing [DOI] 10.1371/journal.pgen.1008915 PMC 바로가기 [Article Type] Research Article
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesisReview Article Published on 2020-06-072024-09-04 Journal: Journal of infection and public health [Category] 대상포진, [키워드] Ageing COVID-19 Cytokine storm NAD+ telomeres [DOI] 10.1016/j.jiph.2020.06.004 PMC 바로가기 [Article Type] Review Article
Cellular aging dynamics after acute malaria infection: A 12‐month longitudinal study급성 말라리아 감염 후 세포 노화 역학: 12개월 종단 연구Original Article Published on 2017-11-162024-08-12 Journal: Aging Cell [Category] 말라리아, [키워드] CDKN2A cellular aging malaria Plasmodium falciparum telomerase telomeres [DOI] 10.1111/acel.12702 PMC 바로가기 [Article Type] Original Article
Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association bind binding Cancer caused cells chromatin chromosome chromosomes complex difficulty DNA DNA binding DNA break DNA breaks DNA replication double-stranded elements elongation End facilitate finding followed by function generate Genome hallmark independent induce interstitial lead mechanism NHEJ non-homologous occur physical predict Previous studies protein-protein interaction proximal reduce Region repair Replication replication fork reported Site solution telomerase telomere telomeres transition turn yeast [DOI] 10.1371/journal.pgen.1006479 PMC 바로가기 [Article Type] Research Article