Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2막 융합을 방해하는 화합물을 식별하기 위해 광범위하게 적용 가능한 바이러스 없는 이중 보고자 분석: HSV-1 및 SARS-CoV-2에 대한 성능Article Published on 2022-06-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alkaline alkaline phosphatase antiviral agent Antiviral agents cell-cell fusion cell–cell fusion Compound doxycycline dual reporter assay Efficacy enzyme expressed expression fluorescent fusion inhibition HSV-1 identify inhibitors Internal control marker membrane fusion nanoluciferase nuclear Pathogens performance phosphatase quantification Replication reported reporter reporter fusion reporter gene SARS-CoV-2 secreted secreted alkaline phosphatase secreted nanoluciferase. Sensitivity and specificity Tetracycline transient transfection Vero Cell Vero cells viral pathogens was tested [DOI] 10.3390/v14071354 PMC 바로가기 [Article Type] Article
Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications급성 호흡 곤란 증후군(ARDS) 및 중증 COVID-19에 대한 테트라사이클린 용도 변경: 최근 간행물에 대한 비판적 논의Article Published on 2022-05-012022-09-11 Journal: Expert opinion on investigational drugs [Category] COVID19(2023년), SARS, 신약개발, [키워드] activities acute respiratory distress acute respiratory distress syndrome addition antibiotic antiviral activity approach ARDS Area benefit Combination COVID-19 COVID-19 pandemic COVID-19 patients Critical doxycycline Drug repurposing Effectiveness Efficacy Evidence expert fibrosis immunomodulatory incyclinide inflammatory reaction initial limitation limitations Minocycline overcome pharmacological repurposing respiratory distress Respiratory distress syndrome safety profile SARS-CoV2 scarcity scientific evidence severe COVID-19 shown syndrome Tetracycline tetracyclines therapeutic potential therapy [DOI] 10.1080/13543784.2022.2054325 PMC 바로가기 [Article Type] Article
In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials임상 시험에서 직접 사용하기위한 잠재적 인 SARS-COV-2 3C- 유사 프로테아제 및 바이러스 RNA- 의존성 RNA 중합 효소 억제제로서 널리 사용되고 내성 된 약물의 실리코 확인에서Article Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제, [키워드] 3 chymotrypsin like protease 3CL pro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approved approved drug Azithromycin binding free energies Bromocriptine chymotrypsin clinical trial clinical trials clinically conivaptan coronavirus coronavirus disease Coronavirus disease 2019 dihydroergotamine docking results drug drug library Drug repurposing dutasteride Eltrombopag enzyme Enzymes Ergotamine evaluate food high affinity Hydroxychloroquine in silico inhibitor initial Interaction issue MD simulation measure molecular molecular dynamics nelfinavir paliperidone persistence physiological conditions protease RdRP repurposing RNA RNA dependent RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2-infected patients searched selected severe acute respiratory syndrome Coronavirus Tetracycline tipranavir Treatment Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1080/07391102.2020.1802346 PMC 바로가기 [Article Type] Article
Tetracycline as an inhibitor to the SARS-CoV-2SARS-CoV-2에 대한 억제제로서의 테트라사이클린Article Published on 2021-07-012022-09-11 Journal: Journal of cellular biochemistry [Category] MERS, SARS, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory attachment bind binding efficiency Cell Chloroquine complement complex Contact coronavirus coronavirus SARS-CoV-2 COVID-19 cytokine doxycycline engage exhibit free energy gentamicin glycine greater human cell hydrogen ICU Infection inhibiting inhibitor lowest mechanical ventilation modulate molecular pathway public health RBD RBD complex RBD residue receptor receptor ACE2 Receptor-binding domain reduce residue SARS-CoV-2 Spike protein Tetracycline the RBD the receptor-binding domain the SARS-CoV-2 the spike protein tyrosine Viral [DOI] 10.1002/jcb.29909 PMC 바로가기 [Article Type] Article
Pleiotropic Effects of Tetracyclines in the Management of COVID-19: Emerging PerspectivesPharmacology Published on 2021-04-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Admission aerobic Anti-inflammatory ARDS Bacteria bacteriostatic antibiotics caspase caused Cell Chloroquine clinical trial complications coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient Cytokine storm doxycycline Effect effective Gram-negative bacteria high risk ICU IL-1 Infectious disease infiltration inhibit intensive care lymphopenia management matrix metalloproteinase mechanical ventilation mechanism mitochondrial Necrosis other coronavirus pathway Pathways Pneumonia proliferation QT interval reducing reduction SARS-CoV-2 Severe case syndrome synergistic Tetracycline tetracyclines treat [DOI] 10.3389/fphar.2021.642822 PMC 바로가기 [Article Type] Pharmacology
Tetracyclines in COVID-19 patients quarantined at home: Literature evidence supporting real-world data from a multicenter observational study targeting inflammatory and infectious dermatosesObservational Study Published on 2021-01-012022-10-05 Journal: Dermatologic therapy [Category] SARS, 임상, [키워드] adult outpatient age Ageusia Anosmia Antiviral effect approved COVID-19 COVID-19 outbreak COVID-19 outpatient COVID-19 patient Dermatology doxycycline drug re-proposal enrolled Evidence in vitro study in vivo Inflammatory inflammatory dermatoses literature mild symptoms Minocycline multicenter multicenter observational study Patient prospective observational study protocol real-world data resolved SARS-CoV-2 Symptom Tetracycline tetracyclines treat Treatment was performed [DOI] 10.1111/dth.14694 PMC 바로가기 [Article Type] Observational Study
IV artesunate for severe malariaArticle Published on 2020-08-102024-08-28 Journal: Med Lett Drugs Ther [Category] 말라리아, [키워드] adverse effects Artemether artemether-lumefantrine artesunate atovaquone/proguanil Chloroquine Clindamycin Coartem dosage doxycycline Drug interactions Efficacy Krintafel lactation malaria malarone mefloquine Pregnancy primaquine Quinine Safety tafenoquine Tetracycline
[Impact of Tetracycline Antibiotic on the Transcriptional Expression of Tetracycline Resistance Genes in Shigella flexneri]테트라사이클린 항생제가 시겔라 플렉스네리의 테트라사이클린 내성 유전자 전사 발현에 미치는 영향Article Published on 2020-08-082024-08-22 Journal: Huan Jing Ke Xue [Category] 세균성이질, [키워드] expression level gene abundance Shigella flexneri Tetracycline tetracycline resistance gene.
Synergistic Effect of a Pleuromutilin Derivative with Tetracycline against Streptococcus suis In Vitro and in the Neutropenic Thigh Infection ModelArticle Published on 2020-08-012023-05-31 Journal: Molecules [Category] Fulltext, 조류인플루엔자, [키워드] checkerboard assays combination therapy Streptococcus suis Tetracycline thigh infection model time-killing assays [DOI] 10.3390/molecules25153522 PMC 바로가기 [Article Type] Article
Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical DosingArticle Published on 2019-10-222024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Chemotherapy chloramphenicol ciprofloxacin Clindamycin doxycycline malaria Pharmacodynamics pharmacokinetics PK/PD Plasmodium falciparum Tetracycline