Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer TherapyPerspective Published on 2023-12-222024-09-05 Journal: Cells [Category] update2024, [키워드] Cancer proteasome-mediated degradation protein post-translational modifications synthetic lethality therapeutic approaches ubiquitination [DOI] 10.3390/cells13010029 PMC 바로가기 [Article Type] Perspective
The FSHD jigsaw: are we placing the tiles in the right position?article Published on 2023-10-142024-09-05 Journal: Current opinion in neurology [Category] update2024, [키워드] Biomarkers clinical phenotype DUX4 epigenetics facioscapulohumeral muscular dystrophy magnetic resonance imaging therapeutic approaches [DOI] 10.1097/WCO.0000000000001176 PMC 바로가기 [Article Type] article
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promiseReview article Published on 2022-11-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] SARS, 바이오마커, 변종, 치료제, [키워드] addition anti-inflammatory property Antiviral antiviral action antiviral therapies changes Complication COVID-19 COVID-19 pandemic current Cytokine storm death direct infection endothelial damage Endothelium Evidence function host cell Hydrogen sulfide Hyperinflammatory Infection Inflammation iNOS limit nitric oxide occur platform Protective pulmonary damage rationale reduce Respiratory failure Respiratory system resulting SARS-CoV-2 signaling molecule supportive therapy therapeutic approaches thrombosis Treatment Vascular vasculature viral infection viral infections [DOI] 10.1016/j.niox.2022.08.003 [Article Type] Review article
Long Covid: where we stand and challenges aheadArticle Published on 2022-10-012022-11-15 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 진단, [키워드] addition Affect Autoimmunity Brain Breakthrough infection cardiovascular system complex defined disease driver EBV Health care system Inflammation initial kidney Long Lungs manifestation mechanism multifactorial organ organs other organ PASC Pathogenesis pathway persistence reduce SARS-CoV-2 SARS-COV-2 infection Symptom therapeutic approaches tissue vaccination virus [DOI] 10.1038/s41418-022-01052-6 PMC 바로가기
Neuroinflammation in Dementia-Therapeutic Directions in a COVID-19 Pandemic SettingArticle Published on 2022-09-222022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] activate Activation Affect cognitive complications Concentration COVID-19 cytokine production Dementia direction dysfunction Efficacy Factors Glia glial cell glial cells group of diseases heterogenous highlight human organism IL-1β immune response Inconclusive Inflammation Inflammatory Intervention molecular neurodegenerative Neuroinflammation Neuron NSAID outcome pathology peripheral pro-inflammatory signaling provide resulting risk SARS-CoV-2 setting shown Side effects therapeutic approaches TNF TNF antagonist TNF antagonists while [DOI] 10.3390/cells11192959 PMC 바로가기
COVID-19 and lung cancer: update on the latest screening, diagnosis, management and challengesArticle Published on 2022-09-012022-11-16 Journal: The Journal of international medical research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Alter approach Cancer cause caused complex Complication coronavirus coronavirus disease COVID-19 COVID-19 complications COVID-19 pandemic death deleterious effect Diagnosis disease Efficacy healthcare Healthcare system identify immune Immune checkpoint inhibitors inhibitor International lung lung cancer management Modification oncology pandemic Patient PROTECT Protecting public health crisis Radiation recommendations SARS-CoV-2 SARS-COV-2 infection Screening therapeutic approaches therapy Treatment unique [DOI] 10.1177/03000605221125047 PMC 바로가기
Mechanisms of COVID-19 pathogenesis in diabetes당뇨병에서 COVID-19 발병 기전의 메커니즘Review Published on 2022-09-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 cardiovascular cardiovascular disease caused Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pathogenesis Cytokine storm diabete diabetes Disease progression Effect enzyme global pandemic heart failure Host host cell host cells hypertension Inflammation mechanism multiorgan failure Mutation outcomes Patient receptor receptors resulting risk of infection SARS-CoV-2 SARS-CoV-2 spike proteins severe acute respiratory syndrome Coronavirus therapeutic approaches variety virus [DOI] 10.1152/ajpheart.00204.2022 PMC 바로가기 [Article Type] Review
CoVITEST: A Fast and Reliable Method to Monitor Anti-SARS-CoV-2 Specific T Cells From Whole BloodCoVITEST: 전혈에서 Anti-SARS-CoV-2 특정 T 세포를 모니터링하는 빠르고 신뢰할 수 있는 방법Article Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adjust antibodies Antibody detection automated Blood blood test can be used Cellular immune response cellular immunity cellular response comparable complex convalescent COVID-19 demonstrated determine diagnostic Donor ELISPOT Evidence explained gold gold standard healthy help house humoral immune response humoral immune responses IFN-γ IFN-γ ELISPOT immune protection immune responses Immune status IMPROVE individual less MONITOR pandemic Patient protocol Reinfection SARS-CoV-2 side simple Specific Support T cell T cells Test therapeutic approaches vulnerable patient vulnerable patients weakened immune system [DOI] 10.3389/fimmu.2022.848586 PMC 바로가기 [Article Type] Article
Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2SARS-CoV-2의 복제 주기에 대한 식물 유래 소분자 억제제의 다면적 역할Review Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Anti-inflammatory anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Anti-viral antioxidant antiviral therapeutics approved assembly caused clinical trial compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug candidate Economy Factor Google Scholar help highlight Host inhibiting knowledge mechanism New coronavirus plant plants platform polyprotein public health registry Replication SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules therapeutic approaches therapy Vaccine viral entry Viral replication cycle. [DOI] 10.1016/j.micpath.2022.105512 PMC 바로가기 [Article Type] Review