Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in JapanArticle Published on 2022-10-052022-11-16 Journal: Medicina [Category] COVID19(2023년), SARS, 변종, [키워드] 113 patient and post COVID-19 condition caused change changes in Characteristics characterized cough COVID COVID patient COVID-19 delta variant dysgeusia dysosmia fatigue Frequency hospitalizations illnesses Insomnia Japan Long manifestation material Myalgic encephalomyelitis/chronic fatigue syndrome objective omicron Omicron variant outpatient clinic Patient patients prevalent Result retrospective significantly significantly lower single-center Symptom syndrome the patient three groups university vaccination variant variants viral variant were infected [DOI] 10.3390/medicina58101393 PMC 바로가기
Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variantsArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] average B.1.1.529 B.1.617.2 caused convalescent convalescent COVID-19 patients convalescent individual convalescent individuals coronavirus COVID-19 death Delta delta variant determine escaped global pandemic Infection neutralization neutralization activity neutralize Neutralizing activity Neutralizing antibodies not neutralize not significant omicron Patient performed plasma plasma sample pre-vaccination Pseudovirus neutralization assay raise reduction replaced reported SARS-CoV-2 sera shown significant difference significantly three groups Vaccine variant [DOI] 10.3389/fimmu.2022.975533 PMC 바로가기
Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccinesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-RBD antibody CD19 CD19+ CD3+ CD3+ CD19+ cell CD4+ cell CD4+ T cell Cell cells cellular immunity Clinical characteristics Concentration CXCL10 DNT effector memory enrolled groups humoral immune profiling immune response immune system immunogenicity immunotype inactivated Inactivated vaccine innate immune response liver liver transplant recipient Lymphocyte count monocyte NAb National Neutralizing Neutralizing antibodies neutralizing antibody plasma Population positive proportion provided recipient recipients reported responders responses SARS-CoV-2 SARS-CoV-2 inactivated vaccines severe adverse event single-cell T-cell three groups time TNF-alpha Type vaccination vaccination schedule were recorded [DOI] 10.3389/fimmu.2022.954177 PMC 바로가기
Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB) was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article
Real-World Evidence for COVID-19 Delta Variant’s Effects on the Digestive System and Protection of Inactivated Vaccines from a Medical Center in Yangzhou, China: A Retrospective Observational StudyObservational Study Published on 2022-08-192022-10-04 Journal: International journal of clinical practice [Category] SARS, 바이오마커, 변종, 임상, [키워드] addition Affect alanine aminotransferase ALT analysis of variance ANOVA AST Bilirubin biochemical center changes in Chinese Cohort Coronavirus disease 2019 COVID-19 Critical Critical disease Delta delta variant diagnosed digestive system dysfunction early stage Effect evaluate function Gastrointestinal symptom global public health IL-6 level Inactivated vaccine inactive Infection interleukin 6 (IL-6 investigated lactate dehydrogenase LDH liver dysfunction marker mild illness moderate no significant difference p value Patient prevalent Prevent promoted PROTECT protection public health reported respiratory tract retrospective serum severity Significant significant difference significantly more Sinopharm Sinovac statistically significant Symptom System three group three groups total bilirubin Treatment Vaccine variant was used [DOI] 10.1155/2022/7405448 PMC 바로가기 [Article Type] Observational Study
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과Article Published on 2022-08-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine [DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article
The Risk of Obstetrical Hemorrhage in Placenta Praevia Associated with Coronavirus Infection Antepartum or Intrapartum코로나바이러스 감염과 관련된 근위태반의 산과 출혈 위험 분만 전 또는 분만 중Article Published on 2022-07-272022-09-11 Journal: Medicina [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed antepartum Birth bleeding Childbirth Complication conducted COVID driven by evaluate first trimester group hemorrhage Hemostasis histological change Hospitalization hypertension identify incidence increase infected patients Infection intrapartum labor material no infection objective obstetrical bleeding occurred Patient patients Placenta placenta accreta placenta previa placenta previa. Pregnancy pregnancy-induced hypertension Prematurity presenting Result Retrospective study risk SARS-CoV-2 SARS-COV-2 infection severity significantly Signs and symptoms similarities specific treatment statistically significant difference stratified Symptoms three groups time of delivery viral disease viral infection with infection [DOI] 10.3390/medicina58081004 PMC 바로가기 [Article Type] Article
Temporal trends and differences of SARS-CoV-2-specific antibody responses in symptomatic and asymptomatic subjects: a longitudinal study from Umbria in Italy증상이 있는 대상과 무증상 대상에서 SARS-CoV-2 특이 항체 반응의 시간적 경향과 차이점: 이탈리아 Umbria의 종단 연구Article Published on 2022-07-182022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] anti-S anti-S antibody antibody Antibody Response Antibody responses Antibody titre antibody titres Asymptomatic Clinical severity clinically Cohort correlation COVID-19 Decline Diagnosis discharged Dynamics eligible first visit Follow-up follow-up study group hospital Immunity immunology Infectious diseases Italy longitudinal overtime participant Participants PCR test persistence positive Protein recruited reduced Reinfection remained SARS-CoV-2 SARS-COV-2 infection serological Serological testing significant difference significantly higher Signs and symptoms spike Spike proteins subject subjects Symptom symptomatic symptomatic and asymptomatic Temporal the median three group three groups threshold titre titres Treatment two groups U/mL Variation Virology while without symptom [DOI] 10.1136/bmjopen-2021-056370 PMC 바로가기 [Article Type] Article
A randomised pilot trial of virtual reality-based relaxation for enhancement of perioperative well-being, mood and quality of life Research Published on 2022-07-142022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] 95% CI adherence Affect assigned cancer diagnosis cancer patient Cancer patients changes in Clinical effect Clinical outcome Colorectal cancer control group demonstrated distress Effect feasibility group in both group Intervention intervention group liver no difference Observed participant Patient pilot study Quality of life randomised receiving recruited reduced reported Research resources respiratory rate significantly standard treatment subsequent three groups Treatment Trial vital sign [DOI] 10.1038/s41598-022-16270-8 [Article Type] Research
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA VaccinePfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19 [DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article