Evaluating treatment efficacy in hospitalized COVID-19 patients, with applications to Adaptive COVID-19 Treatment TrialsArticle Published on 2024-04-152024-09-05 Journal: Clinical Trials [Category] update2024, [키워드] clinical status hazard ratio Mortality Odds ratio Time to recovery totality of evidence [DOI] 10.1177/17407745241238443 PMC 바로가기 [Article Type] Article
Time to recovery and determinant factors of COVID-19 patients under treatment in Sidama region, Ethiopia: A retrospective cohort studyResearch Article Published on 2023-12-032024-09-05 Journal: Heliyon [Category] update2024, [키워드] Accelerated Failure Time (AFT) model COVID-19 Ethiopia Sidama region Time to recovery [DOI] 10.1016/j.heliyon.2023.e23245 PMC 바로가기 [Article Type] Research Article
Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopiaarticle Published on 2023-11-052024-09-05 Journal: Pneumonia [Category] update2024, [키워드] COVID-19 Proportional Hazard model Time to recovery [DOI] 10.1186/s41479-023-00119-3 PMC 바로가기 [Article Type] article
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Randomised trial to determine the effect of vitamin D and zinc supplementation for improving treatment outcomes among patients with COVID-19 in India: trial protocolArticle Published on 2022-08-292022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] all-cause mortality assisted ventilation baseline Biomarker Blood clinical trials commenced cough COVID-19 daily dose deficiency defined determine double-blind dysregulated Ethical approval ethical committee Ethics evaluate the effect Fever Final Follow-up hospital Hospital stay host responses India individual symptom Measures Micronutrient Mumbai nutrition occur outcome outcomes participant patients with COVID-19 peer-reviewed Placebo placebo-controlled trial positive individual preventive measure Primary outcome provided randomised recruited recruitment SARS-COV-2 infection secondary Shortness of breath Symptom Time to recovery Treatment outcome Trial trial protocol undergo vaccination was obtained zinc supplementation [DOI] 10.1136/bmjopen-2022-061301 PMC 바로가기 [Article Type] Article
Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 pneumonia: an open-label, randomised clinical trialRandomized Controlled Trial Published on 2022-08-042022-10-04 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] 1:1 28-day mortality 95% CI age assigned Clinical improvement clinical status clinical trial Controlled trial coronavirus disease COVID-19 death demonstrated Dexamethasone discharged Effect Efficacy enrolled Evidence High dose High-dose high-dose group hospitalised hospitalised COVID-19 patient hospitalised patient low dose low-dose male moderate no significant difference Open-label outcome oxygen Oxygen therapy Patient performed Pneumonia Primary outcome randomisation randomised Randomly receive reduced secondary seven-point ordinal scale severe COVID-19 Time to recovery worsening [DOI] 10.1183/13993003.02518-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial
Handling death as an intercurrent event in time to recovery analysis in COVID-19 treatment clinical trialsResearch article Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] 임상, 치료법, [키워드] Analysis clinical trial competing competing risk conducted COVID-19 death detect died discharged evaluate Follow-up handling hospital hospitalized patients moderate mortality risk nine parameter Patient proportion raise reconstructed Research risk survival survival analysis the patient therapy time to event Time to recovery treat Treatment treatment trials Trial [DOI] 10.1016/j.cct.2022.106758 [Article Type] Research article
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort대규모 용도 변경 노력에서 VERO-E6 세포에 대한 세포변성 SARS-CoV-2 스크리닝Article Published on 2022-07-132022-09-11 Journal: Scientific Data [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate anti-inflammatory drug approach Cell Compound COVID-19 COVID-19 disease Dexamethasone Drug discovery drugs effective effort greater highlighting idea identify inhibitor Intensive mechanism Patient patients phenotypic phenotypic screening potential therapies potential therapy reducing mortality Remdesivir repertoire Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection screened shown Support Time to recovery viral infection [DOI] 10.1038/s41597-022-01532-x PMC 바로가기 [Article Type] Article
Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trialRandomized Controlled Trial Published on 2022-06-302022-10-04 Journal: The British Journal of General Practice [Category] COVID19(2023년), SARS, 임상, [키워드] Adaptive platform trial Admission analysed Bayesian models benefit co-primary endpoint Colchicine colchicine group Community Comorbidity Complication COVID-19 COVID-19-related admission CrI criterion death determine hazard ratio Health higher risk hospital IMPROVE median time multi-arm multicentre Odds ratio Open-label other treatment participant positive primary analysis Primary Health Care Probability Prospective randomised randomised controlled trial reduce SARS-CoV-2 Shortness of breath time Time to recovery Treatment Trial usual care with COVID-19 [DOI] 10.3399/BJGP.2022.0083 PMC 바로가기 [Article Type] Randomized Controlled Trial
Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso부르키나파소에서 하이드록시클로로퀸 또는 클로로퀸과 아지트로마이신 조합으로 치료한 COVID-19 입원 환자 및 외래 환자의 회복 시간, 악화 및 사망 평가Observational Study Published on 2022-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI adjusted aggravation assessment association Azithromycin Burkina Faso Chloroquine Chloroquine phosphate clearance death disease dose fatality Follow-up Hydroxychloroquine hydroxychloroquine plus azithromycin information Inpatient Inpatients lower risk multivariable no significant difference no significant differences observational study outcome Outpatient Patient patients with COVID-19 phosphate Poisson model provided receiving retrospective SRAS-CoV-2 statistical time Time to recovery treated Treatment viral clearance Virological with COVID-19 worsening [DOI] 10.1016/j.ijid.2022.02.034 PMC 바로가기 [Article Type] Observational Study