In vivo assessment of TiO 2 based wear nanoparticles in periprosthetic tissuesResearch Paper Published on 2024-05-102024-09-05 Journal: Analytical and bioanalytical chemistry [Category] update2024, [키워드] fractionation Inductively coupled plasma mass spectrometry Raman spectroscopy scanning electron microscopy tissue samples Titanium nanoparticles [DOI] 10.1007/s00216-024-05320-x PMC 바로가기 [Article Type] Research Paper
Massive macroglossia, a rare side effect of COVID-19: clinical, histologic, and genomic findings in COVID-19-positive versus COVID-19-negative patientsArticle Published on 2022-12-012022-11-16 Journal: Oral and maxillofacial surgery [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] African Analysis CD45 COVID-19 Genetic Genetic predisposition Genetic testing genomic histologic histology Histopathology identify IHC immune cells immune response immunohistochemistry include Inconclusive individual infected with SARS-CoV-2 Intubated massive oral oral pathology oral surgery Oral surgery. organ Patient persistence Result retrospective robust Secondary objective Sequencing Side effect susceptibility tissue samples tissues whole-exome sequencing [DOI] 10.1007/s10006-021-01031-0 PMC 바로가기
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care Research Published on 2022-05-242022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect amplify analytical sensitivity assays Cancer Cancer cells cervical cancer Combination complement demonstrated DNA Efficacy expression HPV Infection ISFET isothermal amplification limit of detection majority marker molecular target mRNA point-of-care resolved selected single copy strain tissue tissue samples tissues transcriptase transistor virus [DOI] 10.1038/s41598-022-12557-y [Article Type] Research
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic Transcriptomic profiling type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
Portable real-time colorimetric LAMP-device for rapid quantitative detection of nucleic acids in crude samples원유 샘플에서 핵산의 빠른 정량적 검출을위한 휴대용 실시간 비색 램프-기기Article Published on 2022-03-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Accuracy amplification Analysis biomedical engineering BRAF Cancer clinical utility COVID-19 testing demonstrated Detection limit Device diagnostics extracted RNA feature LAMP Loop-mediated isothermal amplification nucleic acid PCR-based techniques phenol Phenol red platform point-of-care promise quantification Quantitative Quantitative analysis real time Saliva sensitivity simplicity specificity swabs tissue tissue sample tissue samples Tolerance wild-type [DOI] 10.1038/s41598-022-06632-7 PMC 바로가기 [Article Type] Article
Late Cardiac Pathology in Severe Covid-19. A Postmortem Series of 30 PatientsCardiovascular Medicine Published on 2021-10-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] adipose alteration Analysis Arterial hypertension Atherosclerosis Autopsy cardiac Cardiac pathology cardiovascular cardiovascular condition chronic heart failure Cohort Comorbidity condition COVID-19 death died disease Evolution heart histological histopathological finding Hospital stay hypertrophic cardiomyopathy Infection Inflammation invasive lesion macroscopic male median age median time myocarditis obesity pathological finding Patient patients performed Postmortem RNA RT-PCR SARS-CoV-2 Sery severe COVID-19 symptoms onset tissue samples Two patient valve replacement ventricular [DOI] 10.3389/fcvm.2021.748396 PMC 바로가기 [Article Type] Cardiovascular Medicine
Dysbalance of ACE2 levels – a possible cause for severe COVID-19 outcome in COPDACE2 수준의 불균형 - COPD에서 심각한 COVID-19 결과의 가능한 원인Article Published on 2021-09-012022-09-11 Journal: The journal of pathology. Clinical research [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Arterial hypertension CD147 change changed changes in chronic lung disease chronic lung diseases chronic obstructive chronic obstructive pulmonary disease circulating cofactor controls COPD coronavirus Course COVID-19 datasets decrease determined by Donor downregulated elevated enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epithelial cells expression expression levels EZR ezrin fibrosis furin Gene Expression Healthcare system Healthcare systems healthy control histological analysis hypertension infection mechanism Localization lung Lung disease lung tissue obstructive pulmonary disease outcome Patient patients plasma Plasma levels plasma samples Protective pulmonary arterial hypertension pulmonary disease pulmonary fibrosis pulmonary hypertension putative receptor quantitative PCR reduced Region risk factor Risk factors RNA sequencing sACE2 SARS-CoV-2 SARS-COV-2 infection scRNAseq Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Single-cell RNA sequencing susceptibility tissue expression tissue sample tissue samples TMPRSS2 TMPRSS2 expression transmembrane serine protease transmembrane serine protease 2 viral entry virus were used [DOI] 10.1002/cjp2.224 PMC 바로가기 [Article Type] Article
The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues두 개의 원숭이 종에서 SARS-COV-2 감염의 급성기 후에는 폐 및 외부 조직에서 진행중인 바이러스 복제 및 병리의 징후와 관련이 있습니다.Article Published on 2021-08-232022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] activated acute phase animal models Computed tomography Conjunctiva consequence COVID-19 cynomolgus macaque cynomolgus macaques detectable Extrapulmonary extrapulmonary tissue feces heart histological Histopathology humans immune activation Infection investigated lesion lung lung tissue Lungs Lymph node lymph nodes macaque macaques Messenger RNA necropsy NHPs non-human primates nose nose and throat phase positron emission Positron emission tomography pulmonary pulmonary lesion pulmonary lesions respiratory respiratory tract rhesus salivary salivary gland SARS-CoV-2 SARS-COV-2 infection SIGN Specy tissue sample tissue samples tomography tracheobronchial tracheobronchial lymph nodes Viral Viral RNA virus replication [DOI] 10.3390/v13081673 PMC 바로가기 [Article Type] Article
Intravenous, Intratracheal, and Intranasal Inoculation of Swine with SARS-CoV-2SARS-COV-2를 사용한 돼지의 정맥 내, 쇄골 내 및 비강 내 접종Article Published on 2021-07-302022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition animal model animals Antibody titer change Clinical signs collected Contact coronavirus D614G Diseases Epidemiology experiment greater group histologic Host human SARS-CoV-2 Infectious diseases inoculation intermediate hosts intranasal route intratracheal intravenous isolate Laboratory multiple coronaviruses Mutation naïve nasal/oral swab necropsy Neutralizing antibody titer New York City PCR positive pig PIGS positive rectal swab Rectal swabs reservoir reservoirs respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread Support susceptibility susceptible swine tiger tissue sample tissue samples titers Viral viral replication virus virus isolation [DOI] 10.3390/v13081506 PMC 바로가기 [Article Type] Article