Recent Insights into the Molecular Mechanisms of the Toll-like Receptor Response to Influenza Virus InfectionReview Published on 2024-05-292024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] adjuvant Influenza virus TLR agonist Toll-like receptor [DOI] 10.3390/ijms25115909 PMC 바로가기 [Article Type] Review
Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory NanocarriersArticle Published on 2023-12-202024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] cell-free DNA DAMP Inflammation PAMP Toll-like receptor [DOI] 10.3390/pharmaceutics16010010 PMC 바로가기 [Article Type] Article
Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infectionResearch Article Published on 2023-11-302024-09-05 Journal: JHEP Reports [Category] update2024, [키워드] HBV cure Hepatitis B virus Immunotherapy oral antiviral small molecule Toll-like receptor viremic [DOI] 10.1016/j.jhepr.2023.100975 PMC 바로가기 [Article Type] Research Article
Interferon at the crossroads of SARS-CoV-2 infection and COVID-19 diseasearticle Published on 2023-06-242024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] coronavirus Innate immunity interferon RIG-like receptor Toll-like receptor viral immunology [DOI] 10.1016/j.jbc.2023.104960 PMC 바로가기 [Article Type] article
Nasopharyngeal epithelial cells from patients with coronavirus disease 2019 express abnormal levels of Toll-like receptorsResearch Article Published on 2023-01-182024-09-05 Journal: Pathogens and global health [Category] update2024, [키워드] Coronavirus disease 2019 epithelial cell Inflammation severe acute respiratory syndrome coronavirus 2 Toll-like receptor [DOI] 10.1080/20477724.2023.2166378 PMC 바로가기 [Article Type] Research Article
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeArticle Published on 2022-11-032022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] Analysis association chromosome Cohort controls country COVID-19 Deleterious disease expected Genetic genetics Genome-wide association study identify increase in initiative loci outcome outcomes Pathogenesis performed rare variant Result severe disease Support susceptibility the SARS-CoV-2 TLR7 Toll-like receptor variant whole-genome sequencing with COVID-19 [DOI] 10.1371/journal.pgen.1010367 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Contribution of T- and B-cell intrinsic toll-like receptors to the adaptive immune response in viral infectious diseasesarticle Published on 2022-10-122024-09-02 Journal: Cellular and Molecular Life Sciences [Category] 대상포진, [키워드] Adaptive immune response B cells Immunotherapy T cells Toll-like receptor viral infection [DOI] 10.1007/s00018-022-04582-x PMC 바로가기 [Article Type] article
Human genetic basis of severe or critical illness in COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome affecting association Asymptomatic base caused contribute coronavirus COVID-19 Critical Critical illness death determinant disease disease severity enhanced Enzymes Factor Genetic Genetic variation genetic. Host Human human leukocyte antigen immune component indicated Interaction Interleukins loci mild infection morbidity and mortality multi-organ dysfunction outcome Precision preventive measure Respiratory failure SARS-CoV-2 SARS-CoV-2 receptor Serine severity of COVID-19 Toll-like receptor transmembrane [DOI] 10.3389/fcimb.2022.963239 PMC 바로가기
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기