Combinatorial Host-Response Biomarker Signature (BV Score) and Its Subanalytes TRAIL, IP-10, and C-Reactive Protein in Children With Mycoplasma pneumoniae Community-Acquired PneumoniaMajor Article Bacteria Published on 2024-08-152024-09-05 Journal: Nanoscale [Category] update2024, [키워드] community-acquired pneumonia host response biomarkers IP-10 Mycoplasma pneumoniae TRAIL [DOI] 10.1093/infdis/jiad573 PMC 바로가기 [Article Type] Major Article Bacteria
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort studyArticle Published on 2022-05-252023-06-18 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, [키워드] Biomarkers COVID-19 CRP host response IP-10 point-of-care testing severity prediction TRAIL [DOI] 10.1016/j.ijid.2022.05.051 PMC 바로가기 [Article Type] Article
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection혈장 프로테옴 지문은 SARS-COV-2 감염의 고유성과 임상 결과를 나타냅니다.Observational Study Published on 2021-12-072022-08-31 Journal: Viruses [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] ADM Analysis analyzed assist AUROC cardiovascular disease circulating clinical Clinical management Clinical outcome Comparative Course COVID-19 death determine diagnostics disease emergency department emergency medicine evaluated fatality fingerprint helping Hospital admission Hospitalization hospitalized patient IL-6 Infection Inflammation intensive care Kinetics MCP-3 pathophysiology Patient PD-L1 plasma plasma protein plasma proteins plasma samples Predictive presenting Protein proteome proteomic proteomics proximity extension assay risk prediction SARS-CoV-2 SARS-COV-2 infection Standard of care stratified subsequent supported symptoms of COVID-19 TRAIL translate [DOI] 10.3390/v13122456 PMC 바로가기 [Article Type] Observational Study
Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients염증 인자의 포괄적 인 프로파일 링은 성장 분화 인자 -15가 COVID-19 환자의 질병 중증도의 지표임을 보여 주었다.Immunology Published on 2021-07-152022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Admission Alanine alanine aminotransferase analyzed aspartate Aspartate aminotransferase Asymptomatic Bioinformatics analysis Biomarker blood cell candidate CD200 change Comprehensive convalescent COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critical differentiation discharge disease severity Elevation ELISA eosinophil eosinophil counts expression level expression levels FABP2 Factor functional GDF15 group groups healthy control identify include Indicator inflammatory factors lymphocyte Mild moderate neutrophil neutrophil count NLR Occurrence Patient patient sera Potential biomarker potential biomarkers predict Prevent Profiling progression Remission Revealed severe COVID-19 severe group severity severity of COVID-19 the disease TRAIL Transferrin VCAM-1 were measured White blood cell white blood cell count [DOI] 10.3389/fimmu.2021.662465 PMC 바로가기 [Article Type] Immunology
A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates3M-052-명반 보조제로 제형화된 효모 발현 RBD 기반 SARS-CoV-2 백신은 인간이 아닌 영장류에서 보호 효능을 촉진합니다Article Published on 2021-07-152022-09-12 Journal: Science Immunology [Category] Fulltext, SARS, 진단, 치료법, [키워드] accompanied accumulated adjuvants antibodies Antibody Response BAL blocked blood monocytes Bone marrow candidate CD8+ T cell Cell contrary controls correlated Decreased domain draining lymph node Efficacy expressed Frequency immune response increase in Lung inflammation MCP-1 monocyte nasal Neutralizing antibodies non-human primate plasma Plasma cell promote promoted Protective provide RBD RBD binding Reactions reduced reduction respiratory tract response rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus secretion Th1 the RBD These data TLR-7/8 TRAIL Vaccine vaccine candidate Viral load viral loads yeast [DOI] 10.1126/sciimmunol.abh3634 PMC 바로가기 [Article Type] Article
A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials임상의가 COVID-19 시험을 위한 항바이러스제를 선택하는 데 도움이 되는 컴퓨터 접근 방식Article Published on 2021-04-272022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 신약개발, 임상, 치료제, [키워드] analysed anti-viral drug Antiviral antiviral treatments antivirals applied approach assist association best build Chemical structure Clinical research clinical trial clinical trials clinician Combination Computational biology and bioinformatics Computational drug computational method Computational methods Computational models coronavirus COVID-19 curated cure database death drug drug target Efficacy experimental protocol experimental protocols genomic help IMPROVE information interactions machine learning model machine learning models mutate mutated Older open positioning predict problems Prophylactic Remdesivir renal Research similarity sofosbuvir Stage Strains Symptoms sync tenofovir Tenofovir alafenamide tenofovir disoproxil the vaccine TRAIL Treatment treatment of COVID-19 Trial umifenovir vaccine efficacy Vaccines virus viruses [DOI] 10.1038/s41598-021-88153-3 PMC 바로가기 [Article Type] Article
Highly activated TRAIL+ CD56bright NK cells are associated with the liver damage in HBV-LC patientsArticle Published on 2021-04-012023-06-13 Journal: Immunology letters [Category] B형 간염, [키워드] CD56(bright) NK cells HBV-related liver cirrhosis Liver damage TRAIL [DOI] 10.1016/j.imlet.2020.12.008
In the long shadow of our best intentions: Model-based assessment of the consequences of school reopening during the COVID-19 pandemic우리의 최선의 의도의 긴 그림자 속에서: COVID-19 전염병 동안 학교 재개의 결과에 대한 모델 기반 평가Research Article Published on 2021-03-252022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] absence Adults amplified Analysis Asymptomatic benefit children Cluster Clusters Combination Community Complication consequence Contact tracing country COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic diagnostic tests discrepancy disease dual emotional epidemiological equity feasibility food Frame Infection initial K-12 lead measure mental health occur Older Older adults open outbreak over Prevalence question receiving reduced reopening return risk robust School Schools seeking shown Spread suggested surveillance testing susceptibility susceptible the disease the United State The United States TRAIL Transmission United States Viral Viral load [DOI] 10.1371/journal.pone.0248509 PMC 바로가기 [Article Type] Research Article
Entry, egress and vertical transmission of SARS-CoV- 2SARS-CoV-2의 진입, 퇴장 및 수직 전송Review Published on 2021-03-012022-09-10 Journal: Journal of Molecular Cell Biology [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults caused children clinical manifestation clinical manifestations coronavirus COVID-19 COVID-19 outbreak demonstrated destruction disease effective entry of SARS-CoV-2 Evidence failure Fatality rate host cells life lung Lungs Mild molecular mechanism much lower Neonate other organ other organs pandemic Pandemics pathogenicity placental transmission pregnant women Psychological recent respiratory SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus TMPRSS2 TRAIL Transmission transmission of SARS-CoV-2 vertical transmission widespread [DOI] 10.1093/jmcb/mjab013 PMC 바로가기 [Article Type] Review