News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meetingArticle Published on 2022-10-152022-11-16 Journal: Biology open [Category] 유전자 메커니즘, [키워드] Biology Biophysics cell differentiation cellular Circular circular RNAs Community COVID19 disease DNA Dogma highlighting information International involved Italian modulating Molecular biology National New Non-coding RNAs, microRNAs Pandemics Protein provided RNA RNA therapies. RNAs Rome Society Stress Therapies therapy transcript translational [DOI] 10.1242/bio.059597 PMC 바로가기
The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adultsArticle Published on 2022-10-012022-11-15 Journal: Cytokine [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 activated Activation airway cells COVID-19 deleted deleted ACE2. expression full-length Genes Hospitalized IFN IFN response interferon-stimulated gene Interferon, ISG15 isoform mucosal nasopharyngeal cells positive positive correlation receptor SARS-CoV-2 subjects the SARS-CoV-2 transcript [DOI] 10.1016/j.cyto.2022.155997 PMC 바로가기
Comparison of Intracellular Transcriptional Response of NHBE Cells to Infection with SARS-CoV-2 Washington and New York StrainsArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] 24 hour acute respiratory syndrome affected analyzed bioinformatics caused Cell cellular coronavirus COVID-19 D614G mutation Data mining death DEGs different time point differentially expressed gene dysregulated Effect epithelial experiment Gene ontology Genome global pandemic GO terms Host host cells host response Host transcriptional response host-virus hpi identify immune IMPROVE include Infection infections inhibited Intracellular mechanism Mutation New York NHBE pathway Pathways Patient positive Post-infection reported response resulting RNA sequencing data SARS-CoV-2 SARS-CoV-2 isolate severe disease shown Signaling signaling pathways similarity stability strain Strains These data transcript translation viral isolate viral spike protein Virology virus virus replication Washington while Wuhan, China [DOI] 10.3389/fcimb.2022.1009328 PMC 바로가기
Human coronaviruses disassemble processing bodiesArticle Published on 2022-08-232022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] 229E caused cells characteristic common cold CoVs contribute coronavirus Coronavirus infection correlated CoVs cytokine cytoplasmic dysregulated dysregulation expression FIVE fluorescent Granule Human human coronavirus IL-6 immune response impacted infected cell Infection information innate immune response mechanism MERS mRNA transcripts NL63 OC43 processing Proinflammatory cytokine proinflammatory cytokines promote Protein respond responsible ribonucleoprotein RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein screened severe SARS-CoV-2 stability submission the N protein the viral nucleocapsid TNF transcript translation unique viral infection virus [DOI] 10.1371/journal.ppat.1010724 PMC 바로가기
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Video meeting signals: Experimental evidence for a technique to improve the experience of video conferencingRandomized Controlled Trial Published on 2022-08-032022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] added All participant benefit carried coded controls disrupt Evidence experiment fatigued group groups IMPROVE information Interaction less limitation limitations lockdowns meeting outcome overcome positive Psychological psychological problem randomised controlled trial replicated signal significantly higher social interaction transcript were given [DOI] 10.1371/journal.pone.0270399 PMC 바로가기 [Article Type] Randomized Controlled Trial
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse seraVFLIP-X 스파이크를 생성하는 원형 mRNA 백신 프로토타입은 마우스 혈청에 의한 SARS-CoV-2 변이체의 광범위한 중화를 제공합니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Amino acid amino acid sequence amino acids Antibody titers B.1.1.529 B.1.617.2 balance BNT162b2 boost cellular immune responses cleavage site COVID-19 vaccine Critical D614G detectable Disulfide disulfide bond E484K Evolution of SARS-CoV-2 FIVE flexible glycosylation greater humoral Humoral and cellular immune responses immune responses immunization immunized induce K417N L452R linear linker mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 N501Y neutralization Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers offer pre-fusion producing proline proline substitutions prolines reduced response S-2P SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sequence sera shown spike Spike protein spike trimer stability suggested T478K the spike protein transcript trimer trimeric Vaccine Vaccines variant variants variants of concern variants of interest VFLIP virus VOCs VOIs wildtype [DOI] 10.1016/j.antiviral.2022.105370 PMC 바로가기 [Article Type] Article
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severityResearch article Published on 2022-07-012022-10-05 Journal: EBioMedicine [Category] 신약개발, 유전자 메커니즘, 임상, [키워드] adverse effect African applied approach clinical investigation Colocalization complex complications conducted coronavirus disease COVID-19 COVID-19 severity COVID-19 treatments drug drug target drug targets Effect ENTPD5 European Europeans event Evidence FCRL3 finding funding genetics GWAS highlight ICAM1 ICAM5 immune system information mendelian randomization Multi-ancestry OAS1 Odds ratio other disease populations Protein protein targets provide provided recent reduce replicated risk sensitivity analysis SERPINA1 severity suggested target targets transcript Trial [DOI] 10.1016/j.ebiom.2022.104112 [Article Type] Research article
Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and OutcomeCOVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window [DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article