Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney InjuryAcute Kidney Injury Published on 2023-04-132024-09-05 Journal: Journal of the American Society of Nephrology [Category] update2024, [키워드] acute renal failure chronic renal failure clinical nephrology congestive heart failure transcription regulation transcriptional profiling [DOI] 10.1681/ASN.0000000000000057 PMC 바로가기 [Article Type] Acute Kidney Injury
Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 InfectionArticle Published on 2021-08-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] A549 acute respiratory syndrome Algorithm Analysis applied biological process Biomarkers Bronchial epithelium bronchial epithelium cells candidate drugs categories caused Cell cell line cells clinical trial co-expression network Combined conducted coronavirus correlated COVID-19 COVID-19 infection COVID-19 patient Defense disease drug drug target effective enrichment analysis evaluate Explainable artificial intelligence gene co-expression network gene signature HEPHL1 human lung epithelium IL-17 in vitro in vivo Infection KEGG pathway lung alveolar machine learning module network NHBE pandemic pathogenesis of COVID-19 pathogenicity pathway PGLYRP4 prognostic Regulation SARS-CoV-2 signaling pathway significantly therapeutic approaches therapeutic targets transcriptional change transcriptional profiling translational treat Treatment type I interferon Vaccine validation viral infection virus WGCNA [DOI] 10.3390/jcm10163567 PMC 바로가기 [Article Type] Article
Transcriptional Profiling of Immune and Inflammatory Responses in the Context of SARS-CoV-2 Fungal Superinfection in a Human Airway Epithelial ModelArticle Published on 2020-12-112022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Aspergillus characterized chemokines component Context coronavirus coronavirus disease COVID-19 deregulation determine epithelial Evidence form highlight Host transcriptional response Human Human airway epithelium IFN indicate induce Infection Inflammatory responses innate immune invasive invasive aspergillosis management mechanism Model monocyte nasal neutrophil Prevalence Profiling response SARS-CoV-2 superinfection transcriptional transcriptional profiling unique [DOI] 10.3390/microorganisms8121974 PMC 바로가기 [Article Type] Article