tumor necrosis factor – Communicable Diseases Research

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis

Immunology Systematic Review

Published on 2024-03-012024-09-05
Journal: Frontiers in immunology [Category] update2024,

[키워드] Comorbidities immunosenescence interleukin 1β interleukin 6 tumor necrosis factor
[DOI] 10.3389/fimmu.2024.1330386 PMC 바로가기 [Article Type] Immunology Systematic Review

Efficacy and safety of upadacitinib in patients with ankylosing spondylitis refractory to biologic therapy: 1-year results from the open-label extension of a phase III study

article

Published on 2023-09-182024-09-02
Journal: Arthritis Research & Therapy [Category] 대상포진,

[키워드] ankylosing spondylitis biologic Inadequate response Janus kinase inhibitor Open-label extension refractory tumor necrosis factor Upadacitinib
[DOI] 10.1186/s13075-023-03128-1 PMC 바로가기 [Article Type] article

Enhanced Mouse Susceptibility to Endotoxin Shock after Plasmodium yoelii Infection Is Correlated with Increased Serum Levels of Lipopolysaccharide Soluble Receptors

Article

Published on 2023-05-162024-08-29
Journal: International Journal of Molecular Sciences [Category] 말라리아,

[키워드] endotoxic shock lipopolysaccharide soluble receptors Plasmodium yoelii 265 BY tumor necrosis factor

The effect of ACE2 receptor, IFN-γ, and TNF-α polymorphisms on the severity and prognosis of the disease in SARS-CoV-2 infection

Original Article

Published on 2023-03-062024-09-05
Journal: Journal of investigative medicine : the official p [Category] update2024,

[키워드] angiotensin converting enzyme Coronavirus disease 2019 disease severity gene variations interferon tumor necrosis factor
[DOI] 10.1177/10815589231158379 PMC 바로가기 [Article Type] Original Article

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis

Epipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다

Article

Published on 2022-08-162022-09-11
Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘,

[키워드] Abrasive addition aggregation Alpha analyzed anti-inflammatory effect Cell chronic chronic fatigue syndrome chronic inflammation contribute cough COVID cytokine cytokine network Cytokines Diseases effective epipharyngeal abrasive therapy (EAT) epipharyngitis epipharynx expression expression pattern fatigue fatigue syndrome Hypothesis IgA IgA nephropathy IL-6 IL-6 expression IMPROVE In situ hybridization induce Inflammatory cytokine Inflammatory cytokines Inflammatory diseases interleukin interleukin 6 interleukin 6 (IL-6) intractable involved Japan Local Long Long COVID Major mechanisms mRNA myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) nasal Nasal cavity Necrosis nephropathy Patient postnasal drip Proinflammatory cytokine reduced reported responsible Sedation significantly lower subject suggested suppressed suppression Symptom syndrome systemic inflammatory disease systemic inflammatory diseases systemic symptoms therapy TNFα treated Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha tumor necrosis factor alpha (TNFα). upper respiratory tract
[DOI] 10.3390/ijms23169205 PMC 바로가기 [Article Type] Article

Tissue repair strategies: What we have learned from COVID-19 in the application of MSCs therapy

Review article

Published on 2022-08-012022-10-05
Journal: Pharmacological research [Category] 바이오마커, 변종, 임상, 치료제,

[키워드] ACE2angiotensin converting enzyme 2 acute lung injury acute respiratory distress syndrome adverse outcome ALIacute lung injury alveolar type 2 cells angiotensin converting enzyme 2 ARDSacute respiratory distress syndrome AstraZeneca AT2salveolar type 2 cells ataxia telangiectasia and Rad3-related ATRataxia telangiectasia and Rad3-related BDNFbrain derived neurotrophic factor brain derived neurotrophic factor BRDbromodomain protein bromodomain protein C-reactive protein CCNG1Cyclin G1 CD147cluster of differentiation 147 Cell Clinical finding cluster of differentiation 147 confirmed case Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients COVID-19coronavirus disease 2019 CRPC-reactive protein Cyclin G1 Cytokine storm DRP1dynamin-related protein 1 dynamin-related protein 1 ECMOextracorporeal membrane oxygenation effective EGFepidermal growth factor Emergency use authorization epidermal growth factor EUAemergency use authorization EVsextracellular vesicles example exhibited Extracellular vesicles extracorporeal membrane oxygenation FGFfibroblast growth factor fibroblast growth factor galanin and gmap prepropeptide GALgalanin and gmap prepropeptide GM-CSFgranulocyte macrophage-colony stimulating factor granulocyte macrophage-colony stimulating factor HBVHepatitis B virus Heme oxygenase-1 Hepatitis B virus hepatocyte growth factor hESCshuman embryonic stem cells HGFhepatocyte growth factor hiPSCshuman induced PSCs HIVhuman immunodeficiency virus HO-1heme oxygenase-1 hPSC-CMshPSC-derived cardiomyocytes hPSC-derived cardiomyocytes hPSCshuman pluripotent stem cells human embryonic stem cells Human immunodeficiency virus human induced PSCs human pluripotent stem cells Hyperinflammatory syndrome IFN-βinterferon-β IFN-γinterferon-γ IFN-λinterferon-λ IGF1Rinsulin like growth factor 1 receptor Infection insulin like growth factor 1 receptor Intensive Interferon-β interferon-γ interferon-λ keratinocyte growth factor-2 KGF2keratinocyte growth factor-2 leukemia inhibitory factor LIFleukemia inhibitory factor management MECP2methyl-CpG binding protein 2 Mesenchymal stem cells methyl-CpG binding protein 2 Microvesicles Moderna Mortality MSCs MSCs therapy MSCsmesenchymal stem cells MVsmicrovesicles National Institutes of Health nerve growth factor NGFnerve growth factor NIHNational Institutes of Health nitric oxide associated 1 NLR family pyrin domain containing 3 NLRP3NLR family pyrin domain containing 3 NOA1nitric oxide associated 1 organ damage organ injury P4HA1prolyl 4-hydroxylase subunit alpha 1 PDGFplatelet-derived growth factor Pfizer PGE2prostaglandin E2 phosphatase and tensin homolog platelet-derived growth factor Preclinical Preferred reporting items for systematic reviews and meta-analyses PRISMAPreferred reporting items for systematic reviews and meta-analyses proinflammatory prolyl 4-hydroxylase subunit alpha 1 prostaglandin E2 PTENphosphatase and tensin homolog Pulmonary infection Randomized controlled trial RCTrandomized controlled trial S-proteinspike protein SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SEMA3Asemaphorin 3 A semaphorin 3 A severe acute respiratory syndrome coronavirus 2 sialyl Lewis X signal transducer and activator of transcription 3 SLeXsialyl Lewis X Spike protein spread of COVID-19 STAT3signal transducer and activator of transcription 3 stem cell TGF-β1transforming growth factor β1 TGFBR1transforming growth factor β receptor I Therapies therapy tissue regeneration TLR4toll-like receptors 4 TMPRSS2transmembrane protease serine protease 2 TNFTumor Necrosis Factor toll-like receptors 4 transforming growth factor β receptor I transforming growth factor β1 transmembrane protease serine protease 2 tumor necrosis factor utility Vaccine Vaccines vascular cell adhesion molecule vascular endothelial growth factor VCAMvascular cell adhesion molecule VEGFvascular endothelial growth factor
[DOI] 10.1016/j.phrs.2022.106334 [Article Type] Review article

Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndrome

Review article

Published on 2022-08-012022-10-05
Journal: Transfusion and apheresis science : official journ [Category] SARS, 바이오마커, 임상, 치료제,

[키워드] member 13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif acute respiratory syndrome ADAMTS-13a disintegrin and metalloproteinase with a thrombospondin type 1 motif American Society for Apheresis approach ARDSacute respiratory syndrome article ASFAAmerican Society for Apheresis available data benefit C-reactive protein Case series Case-control CCPCOVID-19 convalescent plasma Clinical outcome Coagulopathy conducted Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19coronavirus disease 2019 criteria Critically ill patient CRPC-reactive protein CSS CSScytokine storm syndrome Cytokine storm syndrome Cytokines D-dimer Effects Evidence excessive immune response feasibility ferritin FFPfresh frozen plasma fibrinogen level fresh frozen plasma hypercoagulable Hyperinflammatory ICUIntensive Care Unit identify IFNinterferon ILInterleukin immunomodulatory effect improvement Inflammatory factor intensive care unit interferon interleukin interleukin-6 Intervention Length of stay LOSlength of stay Lymphocyte count macrophage activation syndrome management MASmacrophage activation syndrome MODSmultiple organ dysfunction syndrome Mortality multiple organ dysfunction syndrome offer offset PaO2:FiO2pressure of arterial oxygen to fractional inspired oxygen concentration pathologic Patient patients patients with COVID-19 peer-reviewed potential clinical benefits pressure of arterial oxygen to fractional inspired oxygen concentration prevent disease progression Randomized Randomized controlled trial RCTrandomized controlled trial reduce reduce mortality resulting risk role Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary hemophagocytic lymphohistiocytosis selected Sequential Organ Failure Assessment severe acute respiratory syndrome coronavirus 2 sHLHsecondary hemophagocytic lymphohistiocytosis SOFASequential Organ Failure Assessment TAMOFthrombocytopenia-associated multiple organ failure Therapeutic plasma exchange thrombocytopenia-associated multiple organ failure TNFTumor Necrosis Factor TPE TPEtherapeutic plasma exchange treat Treatment tumor necrosis factor while with COVID-19
[DOI] 10.1016/j.transci.2022.103433 [Article Type] Review article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Contribution of CD4+ T cell-mediated inflammation to diarrhea in patients with COVID-19

COVID-19 환자의 설사에 대한 CD4+ T 세포 매개 염증의 기여

Article

Published on 2022-07-012022-09-11
Journal: International Journal of Infectious Diseases [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] ACE2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association CD4/CD8 CD4+ CD4+ T cell CD4+ T cells Cell cells chemokine chemokines Colon contribute correlation analyses Correlation analysis COVID-19 CXCL10 CXCL11 CXCR3 determine diarrhea distribution expressed expression groups Gut identify Inflammation inflammation sites lymphocyte Lymphocyte subset Lymphocyte subsets mechanism Migration mRNA mRNA expression Necrosis no difference Patient patients with COVID-19 percentage percentages performed protease protein levels receptor SARS-CoV-2 SARS-COV-2 infection Serine serine 2 significant difference T cell T cells T-box TNFα transmembrane transmembrane protease serine 2 Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha
[DOI] 10.1016/j.ijid.2022.04.006 PMC 바로가기 [Article Type] Article