Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis심각한 VZV 감염 및 혈구탐식 림프조직구증을 앓고 있는 환자에서 E3 유비퀴틴 리가제 AMFR의 변이에 의한 STING 활성화 손상Article Published on 2024-01-262024-08-16 Journal: Journal of Clinical Immunology [Category] 대상포진, [키워드] AMFR HLH interferon ISG STING ubiquitin ligase VZV.
PROTAC targeted protein degraders: the past is prologue Reviews Published on 2022-01-182022-10-05 Journal: Nature Reviews Drug Discovery [Category] 신약개발, 치료제, [키워드] Cancer clinical development Degradation degrade disease-causing oncology Precision Protein provided reported review Small molecules target target protein therapeutic ubiquitin ligase [DOI] 10.1038/s41573-021-00371-6 [Article Type] Reviews
Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function독특한 SARS-CoV-2 ORF10 변이체의 출현과 단백질 구조 및 기능에 미치는 영향Article Published on 2022-01-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 변종, [키워드] acute respiratory syndrome coronavirus And ubiquitin ligase complex caused Co-occurring mutations comprehension Consequences coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CUL2 disorder Effect ELOB ELOC emergence expected expressed Frame highlight host protein human protein human proteins interact intrinsic Intrinsic protein disorder lung tissue MAP7D1 Mutation Open reading frame ORF10 pathogenicity PPT1 predicted Protein public health RBX1 Research respiratory SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single mutation THTPA TIMM8B ubiquitin ligase unique variant variants virulence virus ZYG11B [DOI] 10.1016/j.ijbiomac.2021.11.151 PMC 바로가기 [Article Type] Article
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection시겔라 유비퀴틴 리가제 IpaH7.8은 가스더민 D를 분해 대상으로 삼아 파이로ptosis를 방지하고 감염을 가능하게 한다.Article Published on 2021-10-132024-08-22 Journal: Cell Host & Microbe [Category] 세균성이질, [키워드] GSDMD Inflammasome proteasome pyroptosis Shigella ubiquitin ligase virulence
Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populationsMycobacterium tuberculosis 감염에 대한 내성에 대한 게놈 차원의 연관성 연구는 3개의 별개 집단에서 10q26.2의 유전자좌를 확인합니다Research Article Published on 2021-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95%CI activating ADAM12 allele Analysis association C10orf90 characterized chromosome Cluster Cohort Contact decreased expression defined Diagnosis ENCODE Endemic enrolled epidemiological Evidence exposure to France French Genome-wide association study genome-wide significant genotyped household contact household contacts identify IFN-γ independent individual infected individual infected individuals Infection inter-individual interferon Interferon-gamma intronic region lead locus Lymphocytes monocyte Monocytes Mycobacterium tuberculosis natural history outcome p53 patients performed Population populations positive proportion Protective Release replicated selected shown skin Skin test South Africa subject Suppressor gene Test Th17 transcription factor TST Tuberculin tuberculin skin test Tuberculosis Tumor tumor suppressor tumor suppressor gene ubiquitin ligase upstream Variability variant variants [DOI] 10.1371/journal.pgen.1009392 PMC 바로가기 [Article Type] Research Article
A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum플라스모듐 팔시파룸(Plasmodium falciparum)에서 변경된 퀴닌 및 퀴니딘 반응에 대한 새로운 후보 유전자로서의 HECT 유비퀴틴-단백질 리가제Research Article Published on 2014-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Altered Analysis antimalarial antimalarial drug Asia association candidate candidate gene changes in chromosome chromosome 13 complex conducted contribute contributing to cross cytotoxic activity defend demonstrated drug Efficacy experiment Factor Factors Genetic genetic screens genetic trait identify IMPROVE initial isolate Laboratory Ligase likelihood locus malaria malaria parasite moderate multiple allele multiple alleles mutated novel occur P. falciparum Plasmodium falciparum preservation progeny Quantitative quantitative trait locus quinidine Quinine response responsiveness segment sensitivity strain subset Surveillance susceptibility These data Treatment treatment failure ubiquitin ligase [DOI] 10.1371/journal.pgen.1004382 PMC 바로가기 [Article Type] Research Article
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene [DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article