Competitive Endogenous RNA Network Activates Host Immune Response in SARS-CoV-2-, panH1N1 (A/California/07/2009)-, and H7N9 (A/Shanghai/1/2013)-Infected Cells경쟁적인 내인성 RNA 네트워크는 SARS-CoV-2-, panH1N1(A/California/07/2009) 및 H7N9(A/Shanghai/1/2013)에 감염된 세포에서 숙주 면역 반응을 활성화합니다Article Published on 2022-01-302022-09-11 Journal: Cells [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 치료기술, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Apoptosis autophagy Avian Influenza binding Cell cellular coronavirus Coronaviruses downregulated gene endogenous expression H1N1 H7N9 Hope host cell host cells in viral indicated infected cells Infection Influenza influenza A influenza A virus influenza A viruses Influenza virus inhibit Interaction involved IRF1 IRF1 mRNA lncRNA metabolic pathways molecular mechanism molecular mechanisms mRNA network noncoding RNA Other outbreak p53 p53 signaling pathway pandemic pathogenicity pathway pertussis provide Regulation Research respiratory respiratory virus response responsible RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2- severe acute respiratory syndrome Coronavirus signaling pathway susceptibility therapeutic agent therapeutic agents these viruses three group three groups Transcriptome Tuberculosis unique upregulated upregulated gene upregulation Viral viral pathogenicity virus viruses [DOI] 10.3390/cells11030487 PMC 바로가기 [Article Type] Article
Molecular Mechanisms of Cardiac Injury Associated With Myocardial SARS-CoV-2 InfectionCardiovascular Medicine Published on 2022-01-202022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] activated acute respiratory syndrome Analysis Apoptosis Bioinformatics analysis cardiac cardiac injury caused Cell cellular coronavirus Coronavirus disease 2019 COVID-19 Cytokine activation dataset DEGs differentially expressed gene drug enrichment analysis excessive inflammatory response expression profiling functional Gene Expression Omnibus Genes Genome GEO GSEA hypoxia immune Inflammation inhibited Injury involved KEGG Kyoto myocardial injury Ontology Pathogenesis Pathway analysis patients with COVID-19 PPI Protein–protein interaction reduction response resulting RNA-Seq SARS-CoV-2 SARS-COV-2 infection Spread upregulated gene was obtained [DOI] 10.3389/fcvm.2021.643958 PMC 바로가기 [Article Type] Cardiovascular Medicine
Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue RegenerationImmunology Published on 2022-01-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] “cytokine storm” affected Alter Analysis biological function bronchoalveolar lavage sample CD40 Cell cell proliferation Cell therapy cell types chemotaxis clinical conditions Control COVID-19 COVID-19 patient Cytokine storm cytoplasmic Data analysis dispersion FHL2 Genes IFNGR1 IFNGR2 immune individual individuals induce inhibitor involved lung marker MDA5 mesenchymal stem cell Mild mild case mild COVID-19 patients MSC MSCs Necrosis NF-κB NFKBIA not express OPTN overexpression paracrine Patient performed PKR PPP2CB promote inflammation pulmonary receptors regeneration RNA secretion sequence Severe case severe COVID-19 single cell RNA sequencing single-cell RNA-seq STEM stem cell Target genes therapeutic therapeutic potential therapy for COVID-19 these cell tissue tlr-3 TLRs TNFR1 TNFR2 Transcription transcriptionally treat triggered upregulated upregulated gene upstream virus virus load [DOI] 10.3389/fimmu.2021.780900 PMC 바로가기 [Article Type] Immunology
Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions전사체 연구에 따르면 COVID-19가 주요 건강 상태에 미치는 병태생리학적 영향Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ADAM8 Analysis association canakinumab Captopril Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 progression diabetes Diabetes Mellitus disease downregulation drug candidate dysregulated Factors gene expression analyses Genes genetic determinant genetic determinants health condition hypertension Inflammatory responses influence influences IRF7 lung cancer mechanism METTL7A Microarray MicroRNAs molecular basis MX2 Myocardial infarction notable outcome Pathogenesis pathophysiological Pathways patients Potential biomarker potential biomarkers PPARGC1A predominant prevalent prognostic provide Regulatory rilonacept RNA-Seq SARS-CoV-2 severity shared pathway shared pathways signaling pathway therapeutic transcription factor transcription factors upregulated gene upregulated genes upregulation [DOI] 10.1093/bib/bbab197 PMC 바로가기 [Article Type] Article
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses통합 생물정보학 분석을 기반으로 한 COVID-19 및 뎅기열 숙주 인자 상호작용 네트워크 식별Immunology Published on 2021-07-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition Analysis bioinformatics bioinformatics analyses Biological functions biological process build candidate drug candidate drugs categories CCL2 CCL4 Clinical practice Co-infection conducted contribute coronavirus disease Coronavirus disease 2019 COVID-19 Dengue Dexamethasone drug dysregulated enrichment analysis expressed Factor Genes Genistein Health crisis Host host factor interaction networks ICAM-1 identification identify IL-1 Interaction international public health Intervention lung management mechanism molecular Molecular Complex Detection network outbreak pathologic pathway performed potential therapeutic agents potential therapeutic target potential therapeutic targets PPI probe protein-protein interaction provide raised receptor signaling respiratory Respiratory disease Result resveratrol screened signaling pathway signaling pathways significant effect significant pathways target therapeutic agents TNF-α Toll-like receptor Treatment upregulated gene upregulated genes [DOI] 10.3389/fimmu.2021.707287 PMC 바로가기 [Article Type] Immunology
Transcriptional Start Site Coverage Analysis in Plasma Cell-Free DNA Reveals Disease Severity and Tissue Specificity of COVID-19 PatientsGenetics Published on 2021-05-282022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory distress affected Analysis antiviral activity Asymptomatic biological processe Biomarker blood cell Blood cells cell-free DNA cfDNA Characteristics Clinical management control group coronavirus disease Coverage COVID-19 COVID-19 patients COVID-19 progression COVID-19 severity critical condition Cytokine storm death demonstrated disease severity DNA downregulated gene evidenced feasibility function Gene Expression high risk immune system individual Infection involved lung cell lung cells mechanism noninvasive plasma plasma DNA provided Region SARS-CoV-2 Severe case severe COVID-19 patient severe COVID-19 symptoms Severe patient severe patients severe pneumonia Site the disease tissue tissue specificity transcriptional Transcriptome TSS coverage upregulated gene utility Variation viral replication [DOI] 10.3389/fgene.2021.663098 PMC 바로가기 [Article Type] Genetics
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2 , Suggesting Severe Symptoms to SARS-CoV-2 InfectionACE2와 TMPRSS2를 모두 발현하는 대장암, SARS-CoV-2 감염에 심각한 증상 시사Society Journal Archive Published on 2021-04-152022-09-10 Journal: Pathology and Oncology Research [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 addition affected analyzed Cancer cancers Care COAD Colon Colorectal Colorectal cancer colorectum coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak DNA methylation DNA methylation levels Epidemic expressing expression Gene Expression health emergency host cell human cancers implicated novel Novel coronavirus novel coronavirus disease overexpression pathogenic Patient rectum reported risk factor SARS-coronavirus SARS-CoV-2 SARS-COV-2 infection systematic analysis TMPRSS2 Tumor tumors upregulated upregulated gene Viral viral entry [DOI] 10.3389/pore.2021.612969 PMC 바로가기 [Article Type] Society Journal Archive
Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids인간 기관지 오르가노이드의 SARS-CoV-2 감염 중 관련 허브 유전자 발현의 탐색 및 검증Genome Database Published on 2021-03-162022-09-10 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] 3D structure model acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed Bioinformatics analysis bronchial organoid CCL2 CCL5 coronavirus COVID-19 CXCL1 CXCL10 CXCL8 Cytokines DEGs differentially expressed gene Differentially expressed genes downloaded downregulated gene EGF exploration expressed expression feasibility FGF2 FN1 Gene Expression Gene ontology Genes genomes GEO Health help high mortality hub genes Human bronchial organoids human bronchus ICAM1 identify IL1B IL6 immune response in vitro model Infection infection mechanism infection rate Interaction KEGG Kyoto Microarray MMP9 mRNA mRNA expression Novel coronavirus Novel coronavirus infection pandemic Pathogenesis pathway Pathways patients PBMC PBMCs Potential treatment PPI prognostic protein-protein interaction Protein–protein interaction R software respiratory Result SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus significantly suggested System three-dimensional structure Treatment upregulated gene were used [DOI] 10.1186/s40246-021-00316-5 PMC 바로가기 [Article Type] Genome Database
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysisResearch Paper Published on 2021-01-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] A549 ACE2 acute respiratory distress acute respiratory syndrome alteration Analysis angiotensin-converting enzyme 2 annotation applied approach bioinformatics caused cells clinical manifestation complement contribute controls coronavirus CoV COVID-19 CoVs current diagnose disease distress dysregulation effective enrichment epithelial exacerbate Gene Expression Gene ontology gene signature Genetic host cell immune system in silico induce Infection Ingenuity Pathway Analysis interferon kill Lung epithelial cells medication NHBE overexpression pandemic pathogenic coronavirus pathway Pathways performed receptor signaling Research response RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severely ill patients syndrome target upregulated gene Venn diagram Visualization were infected [DOI] 10.7150/ijms.52256 PMC 바로가기 [Article Type] Research Paper
Meta-analysis of transcriptome datasets: An alternative method to study IL-6 regulation in coronavirus disease 2019Research Article Published on 2020-12-242022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Analysis Biomarker cardiovascular disease Cardiovasculardisease clinical heterogeneity clinical study Complication conditions coronavirus disease COVID-19 Cytokine release syndrome death Diseases downstream Factor ICAM1 IL-6 immune response mechanism Meta-analysis other disease Patient patients PFKFB3 regulated Regulation Research Respiratory disease resveratrol severe COVID-19 significantly suggested Transcriptome transcriptome dataset transcriptome datasets Treatment upregulated gene virus infection [DOI] 10.1016/j.csbj.2020.12.010 PMC 바로가기 [Article Type] Research Article