Spike deep mutational scanning helps predict success of SARS-CoV-2 cladesArticle Published on 2024-07-032024-09-05 Journal: Nature [Category] update2024, [키워드] SARS-CoV-2 viral evolution Viral immune evasion [DOI] 10.1038/s41586-024-07636-1 PMC 바로가기 [Article Type] Article
When RING finger family proteins meet SARS-CoV-2Review Published on 2022-07-012023-07-08 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] antiviral immunity RNF family proteins SARS-CoV-2 Viral immune evasion [DOI] 10.1002/jmv.27701 [Article Type] Review
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopesArticle Published on 2022-05-252022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adaptive analyses antibodies antibody antigenic structure binding binding site breadth cause circulating common cold virus conformational change coronavirus domain Endemic epitope Evolution glycoprotein Human human coronavirus OC43 Immunity in-depth analysis Infection infections Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope non-neutralizing antibody OC43 persist prefusion S Prevent protective immunity reactive Respiratory disease reveal SARS-CoV-2 subject sustained trimer variants Viral immune evasion while [DOI] 10.1038/s41467-022-30658-0 PMC 바로가기 [Article Type] Article
Plasma Torquetenovirus (TTV) microRNAs and severity of COVID-19혈장 토르케테노바이러스(TTV) microRNA와 COVID-19의 심각성Article Published on 2022-05-132022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Anelloviridae association biological fluids coding sequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity detection disease DNA followed by immune immune evasion in viral incidence rate Inflammatory response investigated involved microRNA MicroRNA expression miRNA miRNAs MONITOR outcome outcomes PCR assay plasma plasma sample plasma samples Prevalence Quantitative rate ratio RT-PCR SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severity severity of COVID-19 significantly Spectrum stages subject subjects susceptible TaqMan tested the healthy the patient torquetenovirus Variation variations Viral immune evasion Viremia were assessed widespread [DOI] 10.1186/s12985-022-01812-3 PMC 바로가기 [Article Type] Article
Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease천연 비플라본은 SARS-CoV-2 파파인 유사 프로테아제에 대한 강력한 억제제입니다Article Published on 2022-01-012022-09-11 Journal: Phytochemistry [Category] SARS, 치료제, [키워드] Antiviral antiviral immunity cleavage compounds COVID-19 COVID-19 treatment deISGylation. demonstrated effective enzyme exhibited immune evasion in viral inhibitor inhibitors of SARS-CoV-2 inhibitory effect involved molecular docking National natural Natural biflavone nine Papain Papain-like protease promotion protease SARS-CoV-2 Significant Traditional Chinese medicine traditional Chinese medicines Treatment Viral immune evasion viral replication viral spread Virtual screening [DOI] 10.1016/j.phytochem.2021.112984 PMC 바로가기 [Article Type] Article
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of DiseaseReview Published on 2021-10-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Anti-viral antiviral therapy cellular membranes Community conserved contribute COVID-19 pandemic creating develop domain domains Effect Endoplasmic reticulum Express facilitate feature HCV hepatitis C highlight highlighting HIV Host host membrane HPV Human hydrophilic hydrophobic IAV immune evasion immune modulation immunomodulatory effect Infection Influenza Ion ion channels ion homeostasis knowledge mechanisms papillomavirus Polyomavirus Protein Proteins reading regulate replicative Research respiratory SARS-CoV Structure target Transport Treatment Vaccine Viral immune evasion viral infection virion assembly viroporins virus viruses [DOI] 10.3390/v13112165 PMC 바로가기 [Article Type] Review
Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future TherapeuticsReview Published on 2021-09-172024-09-02 Journal: Viruses [Category] 대상포진, [키워드] Antiviral strategies host-virus interaction HSV-1 Viral immune evasion viral replication and pathogenesis virus [DOI] 10.3390/v13091856 PMC 바로가기 [Article Type] Review
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5Article Published on 2021-09-072022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Activation Calu-3 cell caused CCL5 change circulating clade Contact Ex vivo experiment functional Human IFN IFNB1 IFNL1 immune gene in vitro innate immune isolate Lineage lung cell MERS-CoV Middle East nosocomial outbreak onward transmission pandemic parental phenotypic Pneumonia receptor reduced remained Replication replicative fitness respiratory syndrome coronavirus reveal Saudi Arabia sequence Signaling significantly increased South Korea spread to Strains Surveillance viral epidemiology viral evolution Viral immune evasion virus viruses [DOI] 10.1038/s41467-021-25519-1 PMC 바로가기 [Article Type] Article
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function Research Published on 2021-08-122022-10-05 Journal: Nature Structural & Molecular Biology [Category] SARS, 변종, [키워드] A570D ACE2 ACE2 binding amino-acid apo form B.1.1.7 binding cryo-EM structure Deletion demonstrated Effect ENhance enzyme forms Host Interaction modulate molecular Mutation N501Y mutation NAb neutralize neutralizing antibody RBD RBD binding RBDs Receptor binding Receptor-binding domain SARS-CoV-2 B.1.1.7 SARS-CoV-2 pseudovirus Spike protein Strains Substitution The B.1.1.7 the RBD the spike protein variant of SARS-CoV-2 Viral immune evasion [DOI] 10.1038/s41594-021-00652-z [Article Type] Research
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variantsArticle Published on 2021-07-262022-10-04 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Administered Alpha B.1.1.7 B.1.351 benefit coronavirus COVID-19 pandemic de novo determine E484K effective Efficacy expressing in vitro Infection Live attenuated vaccines MONITOR Mutation neutralization neutralization capacity neutralize Neutralizing activity Neutralizing antibodies polymorphism reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-S sera serum serum sample thought vaccination Vaccine Vaccine development Vaccines vesicular stomatitis virus Viral immune evasion VoC VSV-G WHO [DOI] 10.1038/s41467-021-24909-9 PMC 바로가기 [Article Type] Article