Proteomic screening identifies RPLp2 as a specific regulator for the translation of coronavirusArticle Published on 2023-01-092024-09-05 Journal: International journal of biological macromolecules [Category] update2024, [키워드] coronavirus Eukaryotic translation initiation factor eIF4E PEDV Ribosomal protein RPLp2 translation initiation viral nucleocapsid protein [DOI] 10.1016/j.ijbiomac.2023.123191 PMC 바로가기 [Article Type] Article
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVIDArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute phase Antigen Appendix CD68 Convalescent patients COVID COVID-19 defined Diagnosis exhibited explained gastrointestinal tract Immune cell Immunocompromised patient immunohistochemistry individual Long COVID macrophage marker multiplex multiplex immunohistochemistry nucleocapsid protein occur Patient positive Post-acute COVID-19 syndrome raise reported residual SARS-CoV-2 RNA SARS-CoV-2 SARS-COV-2 infection Symptom symptom onset target the SARS-CoV-2 virus tissue tissues Viral antigen viral nucleocapsid protein viral persistence viral replication Viral RNA virus World Health Organization [DOI] 10.3389/fimmu.2022.939989 PMC 바로가기
Anti-SARS-CoV-2 seroprevalence in King County, WA-Cross-sectional survey, August 2020킹 카운티, WA-단면 조사, 2020년 8월의 Anti-SARS-CoV-2 혈청 유병률Article Published on 2022-08-222022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] 95% confidence interval Accuracy age all age groups anti-SARS-CoV-2 antibody best cause children conducted COVID-19 cross-sectional dried blood spot Dried blood spots effective sample size Factor FIVE highest Hispanic Hospitalization Household survey Households Immunoglobulin Immunoglobulin G incidence income Infection King lowest Older participant Positive test Prevalence proportion Protein provided random SARS-CoV-2 Seroprevalence seroprevalence survey Seven Sex Spike protein statistically significant tested the spike protein the viral nucleocapsid Viral viral nucleocapsid protein virus Weighting white [DOI] 10.1371/journal.pone.0272783 PMC 바로가기 [Article Type] Article
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases급성 후 COVID-19는 염증성 장 질환에서 장 바이러스 항원 지속성을 특징으로 합니다Article Published on 2022-08-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Antigen biochemical CD8 Chain Reaction clinical trials Confirmed COVID-19 infection controlled clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Culture detectable endoscopy enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated expression of SARS-CoV-2 flow cytometry globe Gut gut mucosa IBD immune immune response immunofluorescence immunosuppressive immunosuppressive therapy Inflammation Inflammatory bowel disease intestine investigated large intestine majority means Mild nucleocapsid nucleocapsid protein pandemic Patient performed persistence polymerase chain polymerase chain reaction populations Postacute COVID-19 Quantitative quantitative polymerase chain reaction questionnaire reported RNA SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severity Stool syndrome T cells therapy tissue Viral antigen Viral Antigen Persistence. viral nucleocapsid protein viral transcripts virus cultivation [DOI] 10.1053/j.gastro.2022.04.037 PMC 바로가기 [Article Type] Article
Natural SARS-CoV-2 Infection in a Free-Ranging Black-Tailed Marmoset (Mico melanurus) from an Urban Area in Mid-West Brazil브라질 중서부 도시 지역의 자유 범위 검은꼬리 마모셋(Mico melanurus)에서 자연적인 SARS-CoV-2 감염Article Published on 2022-06-012022-09-11 Journal: Journal of comparative pathology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] alveolar septa animal Antigen Area Black-Tailed Marmoset Brazil clinical history COVID-19 female Hepatitis Host human populations immunohistochemistry Interstitial nephritis intestine large intestine liver lung lung tissue Lymph node Lymphocytes lymphoid marmoset Mild motor vehicle nasopharyngeal natural natural infection necropsy New World New World monkey nodule one health oropharyngeal swab pathogen Pathogens peribronchial periportal platyrrhines. Polytrauma pool Protein risk SARS-CoV-2 SARS-COV-2 infection Spike protein spleen state the viral nucleocapsid urban urban area viral nucleocapsid protein Viral RNA viral RNA detection [DOI] 10.1016/j.jcpa.2022.03.005 PMC 바로가기 [Article Type] Article
Inactivation and Recovery of High Quality RNA From Positive SARS-CoV-2 Rapid Antigen Tests Suitable for Whole Virus Genome Sequencing전체 바이러스 게놈 시퀀싱에 적합한 양성 SARS-CoV-2 신속 항원 테스트에서 고품질 RNA의 비활성화 및 회수Article Published on 2022-05-032022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] aligned Antigen antigen testing applied B.1.1.7 can be used circulating variant circulating variants Community Concentration conserved coronavirus 2 demonstrated detect diagnostic diagnostic protocol diagnostic test diagnostic tests each time-point epidemiological Epidemiology Genome genomic sequence identify imperative inactivated Infection lateral flow Lateral flow device Lineage Lineage B.1.1.7 lysed lysis management Omicron variant outbreak positive positive result protocol public health qPCR Quality Rapid Rapid antigen diagnostic test replicating virus respiratory risk Risk management RNA RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 viral sequence Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread stability storage strain Suspension Template Test tested utility Variation viral nucleocapsid protein viral particle Viral particles Viral RNA virus virus genome was used were used whole virus genome sequencing. [DOI] 10.3389/fpubh.2022.863862 PMC 바로가기 [Article Type] Article
Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3pSARS-CoV-2의 고도로 보존된 s2m 요소는 키스 복합체를 통해 이량체화되고 숙주 miRNA-1307-3p와 상호 작용합니다Article Published on 2022-01-252022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, 치료법, [키워드] biological processe causative agent cellular complex conserved coronavirus COVID-19 COVID-19 pandemic discontinuous transcription Diseases element Genome highlight homodimeric Host interact life cycle majority microRNA miRNA molecular mechanism motif Protein Region Replication required RNA SARS-CoV-2 SARS-CoV-2 genome sequence Structure survival the disease the SARS-CoV-2 the SARS-CoV-2 genome the viral nucleocapsid therapeutic drug translation untranslated region viral nucleocapsid protein Viral protein while [DOI] 10.1093/nar/gkab1226 PMC 바로가기 [Article Type] Article
Targeted Detection of SARS-CoV-2 Nucleocapsid Sequence Variants by Mass Spectrometric Analysis of Tryptic Peptides트립신 펩티드의 질량 분광 분석에 의한 SARS-CoV-2 뉴클레오캡시드 서열 변이체의 표적 검출Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid Analysis antigen detection approach approaches Chain Reaction Coronavirus-2 COVID-19 COVID-19 case detect detection expected flexibility gene encoding highlight immunoassay Liquid chromatography mass mass spectrometry methodology minor Modification nasopharyngeal swabs nucleocapsid nucleocapsid protein nucleotide peptide prevalent Protein proteomic Proteomic analysis qRT-PCR Quantitative quantitative reverse transcription-polymerase chain reaction respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single amino acid protein variants Single nucleotide polymorphism single nucleotide polymorphisms Spread Tandem mass spectrometry target the SARS-CoV-2 the viral nucleocapsid Vaccine variant variants variants of SARS-CoV-2 Viral viral nucleocapsid protein Viral variants virus Whole genome sequencing [DOI] 10.1021/acs.jproteome.1c00613 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory MiceSARS-COV-2 관심의 변이체는 호흡기를 감염시키고 야생형 실험실 마우스에서 염증 반응을 유도합니다.Brief Report Published on 2021-12-242022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation addition analyzed B.1 B.1 lineage B.1.1.7 B.1.351 C57BL/6 C57BL/6 mice CCL2 change chemokine chemokines Concentration concern Coronavirus-2 COVID-19 cytokine Cytokines evaluated expression greater histopathological Host host-range hosts IL-1β IL-6 Immune escape infecting Infection Inflammation inoculated intranasally lineages lung lung tissue lung tissues Lungs mice mouse mouse-adapted SARS-CoV-2 mRNA level mRNA levels multiple cytokine multiple cytokines Mutation pathogenicity public health replicated respiratory response robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the spike protein These data TNF-α tract Transmissibility upregulated variant variants of concern Viral Viral load viral nucleocapsid protein virulence virus viruses wild-type [DOI] 10.3390/v14010027 PMC 바로가기 [Article Type] Brief Report
Longitudinal detection of SARS‐CoV‐2‐specific antibody responses with different serological methods다양한 혈청학적 방법을 통한 SARS-CoV-2 특이 항체 반응의 종단적 검출Comparative Study Published on 2021-06-112022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibodies antibody Antibody Response Antigen antigens assays Blood donors cells children collected Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 detect diagnostic eight ELISA ELISAs healthy blood donors highest IgA IgG IgM immunofluorescence Immunoglobulin immunoglobulin A Immunoglobulin G immunoglobulin M immunosorbent indirect immunofluorescence individual infections information Kinetics longitudinal Patient peaked polymerase chain polymerase chain reaction Prevalence Protein provided respiratory S1 domain SARS‐CoV‐2 SARS‐CoV‐2‐infected SARS‐CoV‐2 seasonal coronaviruses selected sensitivities sensitivity sera serological serological assays Serological testing serology serum sample serum samples specific antibodies specific antibody specificity Spike protein substrate symptom onset tested the viral nucleocapsid Viral viral nucleocapsid protein virus [DOI] 10.1002/jmv.27113 PMC 바로가기 [Article Type] Comparative Study