Novel approach based on GQD-PHB as anchoring platform for the development of SARS-CoV-2 electrochemical immunosensorArticle Published on 2022-11-012022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition analyzed antibodies antibody approach Blood carbon Carbon nanomaterial Concentration conditions coronavirus spike protein decrease develop domain Dot DPV Electrochemical devices Fever functional Graphene human serum Immunosensors construction. Interaction investigated matrix effect Modification novel PBS performed platform probe Protein provided pulse quantum RBD SARS-CoV-2 selective SEM serum shown was tested was used [DOI] 10.1016/j.aca.2022.340442 PMC 바로가기
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
One health genomic surveillance and response to a university-based outbreak of the SARS-CoV-2 Delta AY.25 lineage, Arizona, 2021Article Published on 2022-10-312022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses clade Clinical data clone collected Community conducted contributed defined Delta Evidence facilitate Genome genomic genomic data Genomic surveillance Health identify infectious disease outbreak Lineage local public health Mutation new SARS-CoV-2 occurred one health outbreak Phylogenetic analysis positive provided public health RT-qPCR SARS-CoV-2 SARS-CoV-2 genome secondary transmission sequenced single mutation Spread spread of COVID-19 subsequent subset Surveillance targeted interventions the SARS-CoV-2 through contact variant variants was tested wastewater were used [DOI] 10.1371/journal.pone.0272830 PMC 바로가기
Association of Results of Four Lateral Flow Antibody Tests with Subsequent SARS-CoV-2 InfectionArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome adjusted anti-SARS-CoV-2 IgG antibody assist association baseline Cohort cohort study conducted coronavirus Coverage COVID COVID-19 demonstrated disease risk England fire Flow Follow-up hospital IgG Immunity immunoassay immunoassays incidence rate individual Infection investigated Laboratory laboratory assays Lateral Lateral flow device lateral flow device. lateral flow immunoassay Lateral flow test LFIA LFIAs management microbiologically natural infection pandemic participant point-of-care test Poisson regression model Police service Population screening positive predicted prospective cohort study Protective Rapid Rapid test rapid test cassette recruitment Research Result risk risk factor Roche SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 IgG SARS-COV-2 infection specificity subsequent Surescreen susceptibility symptomatic SARS-CoV-2 infection Test threshold United Kingdom unvaccinated populations Vaccine was tested [DOI] 10.1128/spectrum.02468-22 PMC 바로가기
Pre-vaccination RT-PCR negative contacts in workplace settings show high, SARS COV-2 neutralizing antibody levelsArticle Published on 2022-10-252022-11-15 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 진단, [키워드] age anti-SARS-CoV-2 antibody carried characterized Cohort cohort study collected Contact COVID-19 evaluated individual Infection infection control measure neutralization Neutralizing antibodies neutralizing antibody Outbreaks PCR PCR negative contacts positive Protective Ratio risk factor Risk factors RT-PCR SARS-CoV-2 SARS-COV-2 infection selected Seroprevalence significantly higher specific neutralizing antibody tested Transmission dynamics transmission of SARS-CoV-2 vaccination was tested while Workplace Workplace settings. [DOI] 10.1186/s12889-022-14381-5 PMC 바로가기
Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ability ACE2 binding antibody Antibody titer Antigen binding domain binding epitope characterized concern coronavirus 2 coronavirus disease COVID-19 COVID-19 neutralizing antibody Delta domains effective high affinity high stability highlight Infection introduced lung cell Neutralizing neutralizing antibody New omicron pathogen plasma Protein RBD respiratory SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibody Spike protein suggested therapeutic option unique variable variant VNAR therapy was tested was used [DOI] 10.3390/ijms232012267 PMC 바로가기
Early detection of COVID-19 outbreaks using textual analysis of electronic medical recordsResearch article Published on 2022-10-012022-10-05 Journal: Journal of Clinical Virology [Category] 치료기술, [키워드] Algorithm Analysis average Cluster COVID-19 COVID-19 case COVID-19 cases COVID-19 outbreak detect detection develop Early detection eight electronic medical record epidemiological examined FIVE Healthcare provider medical record natural language processing outbreak detection Patient PCR Positive test presenting provided public health Randomly recorded Result resulting selected subsequent Symptom was tested [DOI] 10.1016/j.jcv.2022.105251 [Article Type] Research article
Evaluation of independent self-collected blood specimens for COVID-19 antibody detection among the US veteran populationRandomized Controlled Trial Published on 2022-10-012022-10-04 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] Abbott Abbott SARS-CoV-2 IgG antibody asked assays assigned Blood blood sample capillary Capillary blood collection centrifuged collected COVID COVID-19 COVID-19 antibody COVID-19 infection determine highest IgG ELISA independent Infection Million Veteran Program Mitra MVP participant Randomly SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG sensitivity specificity specimen tested Total vaccination veteran veterans was tested [DOI] 10.1016/j.diagmicrobio.2022.115770 PMC 바로가기 [Article Type] Randomized Controlled Trial
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
EQUIP emergency: can interventions to reduce racism, discrimination and stigma in EDs improve outcomes?Clinical Trial Published on 2022-09-022022-10-05 Journal: BMC health services research [Category] 임상, [키워드] activities activity age Analysis Canada Care clinical collected Community COVID 19 death Department dimension discrimination Emergency Emergency Departments Epidemic equity group Health Health disparities health equity Health inequity IMPROVE Indigenous intensity Intervention Intervention research longitudinal mounted Multiple regression overdose pandemic Patient post-intervention presenting promote question racism reduce reduction Research resource robust shown sick significant decrease significantly Stigma supported survey tested Throughout the study trauma was tested worsening [DOI] 10.1186/s12913-022-08475-4 PMC 바로가기 [Article Type] Clinical Trial