The dimerized pentraxin-like domain of the adhesion G protein–coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forcesarticle Published on 2023-10-182024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] adhesion G protein-coupled receptor adhesion GPCR enterochromaffin cells Extracellular matrix GPR112 homodimerization mucin Paneth cells pentraxin Signal transduction small-angle X-ray scattering X-ray crystallography X-ray structure [DOI] 10.1016/j.jbc.2023.105356 PMC 바로가기 [Article Type] article
Development of the Safe and Broad-Spectrum Aldehyde and Ketoamide Mpro inhibitors Derived from the Constrained α, γ-AA Peptide ScaffoldArticle Published on 2023-06-142024-09-05 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] update2024, [키워드] Broad-spectrum activity COVID-19 Mpro inhibitor SARS-CoV-2 X-ray structure [DOI] 10.1002/chem.202300476 PMC 바로가기 [Article Type] Article
Structure of the Monkeypox virus profilin-like protein A42R reveals potential functional differences from cellular profilinsArticle Published on 2022-10-012023-06-10 Journal: Acta Crystallographica. Section F [Category] 원숭이두창, [키워드] Actin Center for Structural Genomics of Infectious Diseases Emerging infectious diseases Monkeypox poxviruses profilin profilin-like protein A42R. X-ray structure [DOI] 10.1107/S2053230X22009128 PMC 바로가기
Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitutionArticle Published on 2022-09-012022-11-16 Journal: Acta crystallographica. Section D [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor addition amino-acid Analysis base binding binding affinity binding kinetics circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants complex Contact contribute COVID-19 host-pathogen interactions in vitro in vivo model increase increase in Infection Interaction Lineage mice modulate mutant Mutation performed Q498Y RBD RBD-ACE2 RBD–ACE2 complex receptor ACE2 Receptor binding domain reveal SARS-CoV-2 SARS-CoV-2 variant shown Spike protein spike protein Q498Y mutation spike protein receptor binding domain. spike receptor-binding domain Substitution the binding affinity the RBD the SARS-CoV-2 the spike protein while wild-type counterpart X-ray X-ray structure [DOI] 10.1107/S2059798322007677 PMC 바로가기
Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2′- O -methyl transfer by SARS-CoV-2 nsp16MN 2+ SARS-COV-2 NSP16에 의한 효율적인 2'-O- 메틸 전달에 대한 기질을 정렬하는 CAP-0-RNA를 좌표Research Article Published on 2021-06-292022-09-10 Journal: Science Signaling [Category] MERS, SARS, 치료기술, [키워드] absence active site adenosylmethionine aligning Alter backbone binding biochemical capping catalysis coactivator complex conserved Coordinate coronavirus Coronaviruses Degradation Donor drug design efficient ENCODE enzyme Final generate heterodimeric Host host cell host defenses inhibitors innate response insert Interaction mammalian Messenger RNA metal ion metal ions methyl group methyltransferase mRNA nsp10 organism Prevent PROTECT resulting ribonucleotide ribonucleotides RNA RNAs SAM SARS-CoV-2 SARS-CoV-2 genome selective structural evidence Structure structures substrate substrates the SARS-CoV-2 transfer translation triggering unique Viral viral RNAs virus replication X-ray structure [DOI] 10.1126/scisignal.abh2071 PMC 바로가기 [Article Type] Research Article
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitorsReport Published on 2020-04-242022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS, [키워드] 3CL pro administration cause caused complex coronavirus coronavirus disease COVID-19 crystal structure drug target drugs ENhance enzyme exhibit functional health emergency inhibitor lung M pro Novel coronavirus pandemic pharmacokinetic plasma polyprotein protease Protein provide pyridone reveal SARS-CoV-2 SARS-CoV-2 main protease scientist targeting the SARS-CoV-2 translated unliganded Viral proteins Viral RNA virus X-ray structure [DOI] 10.1126/science.abb3405 PMC 바로가기 [Article Type] Report