Biochemistry – Page 10 – Communicable Diseases Research

Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States

COVID-19로 입원한 환자의 심장 부정맥: 미국 서부 지역의 전향적 관찰 연구

Observational Study

Published on 2020-12-282022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, 임상,

Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches

SARS-COV-2에 대한 차세대 멀티에피토프 기반 백신(MEV) 설계: 면역정보학 및 인실리코 접근법

Research Article

Published on 2020-12-222022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] adjuvant Amino acid amino acids analyses antigenic antigenic proteins approach B-cell binding affinity caused conducted coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 demonstrated effective epitope Epitopes Escherichia coli Escherichia coli K-12 system flexible followed by global health security highly antigenic HLA-binding allele HLA-binding alleles human pathogenic toll-like receptors immunogenic profile in silico In silico cloning increased expression indicated K-12 linker MEV MEV codon MEV codons MEV construct MHC class MHC class I MHC class II epitopes molecular molecular docking molecular dynamics multiepitope based vaccine non-allergenic overlapping pandemic pathogenic predicted Protein respiratory Respiratory Coronavirus selected Selected epitopes severe acute respiratory coronavirus significant interaction T-cell target targets Till TLR TLR3 TLR8 Toll-like receptor Vaccine vaccine against SARS-COV-2 vaccine production
[DOI] 10.1371/journal.pone.0244176 PMC 바로가기 [Article Type] Research Article

Coronavirus vaccine development: from SARS and MERS to COVID-19

코로나바이러스 백신 개발: SARS와 MERS에서 COVID-19까지

Review

Published on 2020-12-202022-08-13
Journal: Journal of Biomedical Science [Category] Biochemistry, MERS, SARS, 진단,

Coronavirus-induced coagulopathy during the course of disease

질병 경과 중 코로나바이러스 유발 응고병증

Research Article

Published on 2020-12-172022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 바이오마커, 진단,

[키워드] Activation Administered adult COVID-19 patient adverse outcome age alteration Analysis analyzed anticoagulation Antithrombotic argatroban change Coagulation Coagulopathy comparable coronavirus coronavirus disease Course COVID-19 COVID-19 patient COVID-19 patients D-dimer D-dimer level D-dimer levels D-dimers decrease diagnosed disease elevated event fibrinogen fibrinogen level heparin heparin-induced thrombocytopenia Hospitalized hypercoagulability ICU incidence increased risk intensive care intensive care unit treatment investigated Laboratory low-molecular-weight-heparin male marker mean value observation period outpatients Patient patients died patients treated peak levels Platelet count Prophylaxis proportion prothrombin Prothrombin time receiving required Result retrospective Sensitivity analyses sensitivity analysis significant decrease single-center subsequent Switzerland the disease thrombin thrombin time thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events Thromboembolism Treatment two patients unfractionated heparin university venous ward
[DOI] 10.1371/journal.pone.0243409 PMC 바로가기 [Article Type] Research Article

Recombination events are concentrated in the spike protein region of Betacoronaviruses

재조합 이벤트는 Betacoronaviruses의 스파이크 단백질 영역에 집중되어 있습니다.

Research Article

Published on 2020-12-172022-08-13
Journal: PLoS Genetics [Category] Biochemistry, COVID-19, SARS,

[키워드] accumulate Alter Analysis analyzed approach Author betacoronaviruses change circulating Coronaviral disease severity engage event events gene flow Genome genomic region genomic variation high mutation rate high mutation rates homoplasies homoplasy host cells host tropism human disease implicated include Interaction likelihood limit limits MERS Mutation mutation rate Mutation rates mutations null model occur polymorphism Polymorphisms Population Positive selection random Recombination recombination event Region RNA virus RNA viruses SARS-CoV-2 sequence similarities sequence similarity shown Spike protein strain Strains subject tested the Sarbecovirus the spike protein variant Viral viruses
[DOI] 10.1371/journal.pgen.1009272 PMC 바로가기 [Article Type] Research Article

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

지질 방울은 SARS-CoV-2 복제 및 염증 매개체 생성을 촉진합니다

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] addition Analysis Antiviral biosynthetic CD36 Cell cell death cellular metabolism complex component contribute COVID-19 COVID-19 pandemic COVID-19 patient demonstrated described develop disease donors double-stranded droplet effort electron microscopy energy homeostasis ENhance enzyme expression function homeostasis Host host cell host cells host immunity human cell lines infected cells Infection Inflammation inflammatory mediator inhibited LDs Lipid lipid droplet lipid droplets lipid metabolism mechanism mediator mediators metabolism modulate modulation monocyte Monocytes organelle parasite Pathogenesis pathway Pathways Perspective pharmacological platform PPARγ pro-inflammatory response Protein recruit recruited reduce reduced Regulation Replication RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV2 SARS-CoV2 infection significantly Support target therapeutic intervention Therapeutic strategies therapeutic strategy Transport triggered Vero Cell Vero cells Viral viral particle Viral particles viral replication virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009127 PMC 바로가기 [Article Type] Research Article

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus
[DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article

A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection

SARS-CoV-2 검출을 위한 민감하고 저렴한 멀티플렉스 RT-qPCR 분석

Controlled Clinical Trial

Published on 2020-12-152022-08-13
Journal: PLoS Biology [Category] Biochemistry, MERS, SARS, 임상, 진단, 치료기술, 치료제,

[키워드] (coronavirus disease 2019 acute respiratory syndrome coronavirus assays benefit Better can not caused cellular collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlation COVID-19 diagnostic test diagnostic tests Efficiency false-negative rates feasibility help Herpe identify Inclusion infected individuals material MONITOR Multiplex assay multiplex RT-qPCR nose and throat Novel coronavirus novel coronavirus SARS-CoV-2 nucleic acid nucleic acid extraction nucleic acids pandemic PCR tests probe provide Quality control Quantitative reduce reduced respiratory respiratory syndrome coronavirus 2 reverse transcription PCR robust RPP30 RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 qRT-PCR severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 statistically significant supply swab sample swab samples swabbing symptomatic target Variability Viral viral nucleic acid Viral RNA viral spike
[DOI] 10.1371/journal.pbio.3001030 PMC 바로가기 [Article Type] Controlled Clinical Trial

Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study

ICU에 입원한 COVID-19 환자의 응고 프로파일: 탐색적 연구

Research Article

Published on 2020-12-152022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 치료기술,

[키워드] abnormality addressed alteration anticoagulation Antithrombin aPTT baseline both groups change characterized Coagulation coagulation tests complex Conventional COVID-19 patient D-dimer Day decrease exploratory study fibrinogen Fibrinogen levels fibrinolysis fibrinolytic groups hypercoagulability ICU in both group in both groups INR Laboratory test Laboratory tests less Longitudinal evaluation magnitude median objective organ dysfunction Patient plasma plasminogen Platelet Protein protein C protein S remained Result severity slight increase SOFA SOFA score study period two groups were measured with COVID-19
[DOI] 10.1371/journal.pone.0243604 PMC 바로가기 [Article Type] Research Article

COVID-19 mortality risk assessment: An international multi-center study

COVID-19 사망률 위험 평가: 국제 다기관 연구

Clinical Trial

Published on 2020-12-092022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 임상,

[키워드] 95% CI age Algorithm AUC Blood Blood urea nitrogen C-reactive protein calculator Clinical features Clinical findings Clinical use Cohort collected COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 positive patient creatinine data-driven demographic develop elevated Europe evaluated generate group high risk Hospital admission hospitalized COVID-19 patients hospitals IMPROVE Increased independent international multi-center Laboratory management Mortality mortality rate mortality risk nitrogen oxygen oxygen saturation Patient Patient management patients predict resource risk Risk factors significantly The United States United States urea validation cohorts variable was obtained
[DOI] 10.1371/journal.pone.0243262 PMC 바로가기 [Article Type] Clinical Trial