Biochemistry – Page 13 – Communicable Diseases Research

Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020

2020년 로메(토고) 고위험 인구 중 SARS-CoV-2의 유병률

Research Article

Published on 2020-11-092022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19

676명의 환자를 대상으로 한 코호트 연구에서 D-dimer가 COVID-19의 사망에 대한 중요한 위험 요소임을 나타냅니다.

Research Article

Published on 2020-11-092022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] Admission analyzed C-index C-reactive protein Clinical characteristics cohort study collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical CRP D-dimer D-dimer level D-dimer levels Dimerized plasmin fragment D hazard hazard ratio highest Hospital mortality in-hospital mortality incidence indicate information Lactate lactate dehydrogenase LDH management marker Mortality non-survivor Non-survivors on admission outcome Patient patients PCT predict procalcitonin prognostic remained Retrospective study risk factor Risk factors significantly higher stratified suggested Survivors Treatment worldwide pandemic
[DOI] 10.1371/journal.pone.0242045 PMC 바로가기 [Article Type] Research Article

Targeting ferroptosis in breast cancer

유방암의 ferroptosis 표적화

Review

Published on 2020-11-052022-08-13
Journal: Biomarker Research [Category] Biochemistry,

Development and evaluation of a rapid and simple diagnostic assay for COVID-19 based on loop-mediated isothermal amplification

루프 매개 등온 증폭을 기반으로 한 신속하고 간단한 코로나19 진단 분석법 개발 및 평가

Research Article

Published on 2020-11-042022-08-13
Journal: PLoS Neglected Tropical Diseases [Category] Biochemistry, COVID-19, SARS,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus battery caused clinical clinical evaluation coronavirus COVID-19 COVID-19 case detect development Diagnosis diagnostic Direct highly pathogenic human coronavirus isothermal amplification less Loop-mediated isothermal amplification nasal swab Novel coronavirus outbreak Patient performed platform Pneumonia point-of-care Prevent Probability Rapid required respiratory reverse transcription RNA extraction RT-LAMP rural areas SARS-CoV SARS-CoV-2 SARS-CoV-2 pneumonia severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimens spread of COVID-19 Surveillance Swab Treatment Viral Viral RNA
[DOI] 10.1371/journal.pntd.0008855 PMC 바로가기 [Article Type] Research Article

Characteristics and outcomes of hospitalised patients with acute kidney injury and COVID-19

급성신장손상 및 코로나19로 입원한 환자의 특징 및 결과

Research Article

Published on 2020-11-032022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] Acute kidney injury Admission Adult patients AKI association baseline characteristics Biochemistry Comorbidities COVID-19 Critical care death Deprivation Deterioration diagnosis of COVID-19 disease Escalation foundation hospital hospitalised patient Initially laboratory data mechanical ventilation medications Mortality multiple organ involvement observations outcome overall mortality P-value pandemic Patient patients patients with AKI patients with COVID-19 presenting Prevent Record renal renal disease renal function renal replacement therapy replacement therapy required respiratory Result retrospective retrospective review risk shown Spread the disease Trust university with COVID-19 World Health Organisation
[DOI] 10.1371/journal.pone.0241544 PMC 바로가기 [Article Type] Research Article

Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions

병원 내 COVID-19 사망률 예측인자: 연령, 성별 및 건강 상태에 따른 차이를 탐색하는 포괄적인 체계적인 검토 및 메타 분석

Research Article

Published on 2020-11-032022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] addition age albumin ALT applied AST Bilirubin C-reactive protein cardiac troponin Cardiac troponin I clinical condition clinical conditions Comorbidities Comorbidity Concentration conditions conducted confirmed COVID-19 patients COVID-19 COVID-19 mortality COVID-19 patient creatinine Critical database deaths diabete diabetes Dyspnoea effect size Factor ferritin followed by Haemoglobin Health health condition heterogeneity hospital hypertension In-hospital in-hospital mortality increased mortality interleukin-6 Kidney disease laboratory parameter Laboratory parameters LDH malignancy meta-analyses Meta-analysis meta-regression Mortality nitrogen obesity objective Odds ratio older patient older patients Patient patients Platelet Platelet count populations predictor predictors prognostic effect pulmonary disease random-effects meta-analyses registration number Result risk Sex smoking Subgroup analyses subgroup analysis systematic review the mean the MEDLINE total bilirubin troponin I urea urea nitrogen variable Web of Science
[DOI] 10.1371/journal.pone.0241742 PMC 바로가기 [Article Type] Research Article

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

코로나바이러스 세포 진입 및 복제에서 시스테인 펩티다제의 역할: 카텝신 억제제의 치료 가능성

Review

Published on 2020-11-022022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19,

[키워드] Activation antiviral drug cathepsin inhibitor Cathepsins cell entry cells chymotrypsin Coronaviral coronavirus CoV CoVs cysteine Diseases generate Host host cell humans inhibitor involved lysosomal nonstructural protein nonstructural proteins Nsps outcomes over Papain peptidase positive-sense prevalent processed replicase polyprotein replicase polyproteins Replication respiratory respiratory diseases RNA viruses severe respiratory diseases single-stranded spike glycoprotein spike glycoproteins Spike protein targets therapeutic potential treatment strategy utilization Viral Viral RNA viral RNA synthesis virus attenuation
[DOI] 10.1371/journal.ppat.1009013 PMC 바로가기 [Article Type] Review

Clinical impact of monocyte distribution width and neutrophil-to-lymphocyte ratio for distinguishing COVID-19 and influenza from other upper respiratory tract infections: A pilot study

COVID-19 및 인플루엔자를 다른 상부 호흡기 감염과 구별하기 위한 단핵구 분포 폭 및 호중구 대 림프구 비율의 임상 영향: 파일럿 연구

Research Article

Published on 2020-11-022022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020

회복된 COVID-19 사례에서 SARS-CoV-2 RNA 방출 및 회복된 COVID-19 사례 및 밀접 접촉에서 SARS-CoV-2에 대한 항체 존재, 태국, 2020년 4월-6월

Research Article

Published on 2020-10-292022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses antivirals approved blood sample Blood samples caused clearance close contact combating Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases Defense detectable disease onset Disease surveillance effective emerging disease evaluated examined Hospitalized Host host defenses IgA antibodies IgA antibody IgG IgG antibodies IgM infected individual infected individuals information levels of antibody natural history Patient pattern positive presence of antibody provide recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients remained respiratory SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus spread of COVID-19 tested Vaccine Viral viral clearance Viral RNA Viral RNA shedding
[DOI] 10.1371/journal.pone.0236905 PMC 바로가기 [Article Type] Research Article

Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data

PCR 양성 환자에서 SARS-CoV-2 IgG 항체 반응 평가: 임상 데이터에 대한 9가지 검사 비교

Research Article

Published on 2020-10-272022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] Abbott addressed antibody Antibody test Antibody testing antibody tests asymptomatic patients biosensor Clinical data Clinical practice clinical symptom Clinical symptoms controls correlated correlation COVID-19 patient DiaSorin different time points early stage epidemiological studies epitope Euroimmun explain group highlight house LIPS nine patient groups PCR positive Previous studies previous study ranged Roche S-RBD SARS-CoV-2 antibody test SARS-CoV-2 antibody testing SARS-CoV-2 antibody tests SARS-CoV-2 IgG antibody sensitivity Sensitivity and specificity serum sample serum samples Seven SNIBE specificity symptom onset target protein Variation Viral Viral antigen was performed
[DOI] 10.1371/journal.pone.0237548 PMC 바로가기 [Article Type] Research Article