Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking결정학적 스크리닝 및 컴퓨터 도킹을 통해 확인된 SARS-CoV-2의 Nsp3 매크로도메인에 대한 단편 결합Research Article Published on 2021-04-142022-08-13 Journal: Science Advances [Category] Biochemistry, COVID-19, SARS, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine diphosphate Antiviral Antiviral agents antiviral target binding catalytic chemotype chemotypes conformational coronavirus counteract Data collection differential scanning fluorimetry docking effort enzyme Fluorescence foundation fragment heterogeneity homogeneous host-mediated antiviral adenosine diphosphate–ribosylation signaling inhibitor inhibitors isothermal titration calorimetry macrodomain macrodomain-binders massive Mutation nonpathogenic nonstructural protein 3 physiological temperature protein 3 provide respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Signaling starting point starting points Structure unique virus viruses X-ray data collection [DOI] 10.1126/sciadv.abf8711 PMC 바로가기 [Article Type] Research Article
Polyester nasal swabs collected in a dry tube are a robust and inexpensive, minimal self-collection kit for SARS-CoV-2 testing건조한 튜브에 수집된 폴리에스테르 비강 면봉은 SARS-CoV-2 테스트를 위한 견고하고 저렴하며 최소한의 자가 수집 키트입니다.Research Article Published on 2021-04-142022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, [키워드] addition alternative collected Collection condition conducted COVID-19 demonstrated evaluated followed by Freeze-thaw cycle freeze-thaw cycles identify Laboratory matrix moderate molecular nasal swab nasal swabs offer Patient pediatric polyester populations qPCR required Result RNase P robust SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads Separate specimen specimen collection stability surrogate Swab swabs temperature Transport media Viral Viral RNA warm [DOI] 10.1371/journal.pone.0245423 PMC 바로가기 [Article Type] Research Article
Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review누적 및 전가된 COVID-19 사례와 SARS-CoV-2 감염의 혈청 유병률 비교: 체계적인 검토Research Article Published on 2021-04-022022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, [키워드] anti-SARS-CoV-2 IgG ascertainment Buenos Aires Community country COVID-19 COVID-19 case COVID-19 cases cumulative death estimate Germany greater herd immunity identify IgA antibodies IgA antibody IgM Infection infections magnitude majority Population proportion ranged Region reported representing Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence searched seropositive Serosurvey Serosurveys Spread subject symptomatic people Symptoms trials were assessed [DOI] 10.1371/journal.pone.0248946 PMC 바로가기 [Article Type] Research Article
Seroprevalence of hospital staff in a province with zero COVID-19 casesCOVID-19 사례가 없는 지역의 병원 직원의 혈청 유병률Research Article Published on 2021-04-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, [키워드] 95% CI Antibody test Antibody testing approved association Asymptomatic Chulalongkorn clinical close contact confirmed COVID-19 case contact with country COVID-19 COVID-19 antibody test COVID-19 case COVID-19 cases COVID-19 infection detect Gender had no healthcare hospital Hospital staff IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M incidence infection rate institutional review board IRB less male Mass screening minor symptom minor symptoms no symptoms participant PCR PCR-confirmed PCR-confirmed COVID-19 positive Prevalence Randomly Ranong response rate Result SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-CoV-2 IgM seropositive Seroprevalence silent situation Symptom tested Travel Trial registration university was tested was used [DOI] 10.1371/journal.pone.0238088 PMC 바로가기 [Article Type] Research Article
Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank영국 바이오뱅크에서 기준선 심장대사 프로파일 및 SARS-CoV-2 감염Research Article Published on 2021-04-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, [키워드] 95% confidence interval adjusted age alcohol ancestry ApoB Apolipoprotein Apolipoprotein B baseline BMI body mass body mass index cardiometabolic cardiometabolic risk factor characterized cholesterol coronavirus COVID-19 pandemic diabete diabetes Effect eliminated examined Factor HDL-C hemoglobin Hemoglobin A1c high density lipoprotein LDL-C Logistic regression low density lipoprotein objective Odds ratios pandemic participant positive profile profiles reduced Regulation remained respiratory respiratory infection responsible Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection Sepsis severe respiratory infection Sex significantly Study participants tested Triglyceride triglycerides Type type II diabete Type II Diabetes UK biobank UKB [DOI] 10.1371/journal.pone.0248602 PMC 바로가기 [Article Type] Research Article
Computational epitope map of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 전산 에피토프 지도Research Article Published on 2021-04-012022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, MERS, [키워드] analyses Antibody binding antibody binding site antibody binding sites Author bioinformatics candidate caused characterized COVID-19 vaccine COVID-19 vaccines epitope Epitopes expected flexible full-length glycosylated Health Health crisis highlighting host cell identify immunological impair Infection membrane molecular dynamics Molecular dynamics simulation molecular dynamics simulations patch performed primary antibody Protective Protein rigidity S proteins SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 virus Sequence conservation Spike protein stalk steric Structure structures surface area target targets the SARS-CoV-2 Vaccine design Vaccine development Viral viral entry viral envelope protein viral envelope proteins viral membrane viral surface [DOI] 10.1371/journal.pcbi.1008790 PMC 바로가기 [Article Type] Research Article
Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profilesCOVID-19 임상 표현형 및 관련 동반 질환 및 합병증 프로필 특성화Research Article Published on 2021-03-312022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] Admission Analysis association Characteristics clinical outcomes clinical phenotype clinical phenotypes Clinical practice Clustering collected Comorbidities Comorbidity Complication complications coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 phenotypes database death determine facilitate Future hazard hematologic hematological highest hospitalized patient hospitalized patients hospitals I, II identification identify IMPROVE in-hospital complication increases in Multivariable models outcome outcomes Patient patient population phenotype Phenotypes Principal component principal component analysis profile Regression model renal Research respiratory Result Retrospective analysis therapy Trial utility variable was performed with COVID-19 [DOI] 10.1371/journal.pone.0248956 PMC 바로가기 [Article Type] Research Article
Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium인간 호흡기 상피에서 SARS-CoV-2 및 SARS-CoV에 대한 서로 다른 온도 의존성 바이러스-숙주 역학Research Article Published on 2021-03-292022-08-13 Journal: PLoS Biology [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome coronavirus Affect both virus both viruses Cell culture characteristic clinical feature coronavirus coronavirus 2 CoV infection epithelial epithelial cell exhibit Host host cell host cell response host innate immune response dynamics human respiratory epithelium human-to-human transmission dynamics infected individuals Infection influence innate immune response interferon investigated Lower respiratory tract performed Phylogenetic relationship primary human airway primary human airway epithelial cell culture model pro-inflammatory response pro-inflammatory responses public health replicated Replication replication efficiency replication kinetics respiratory respiratory viruses SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread temperature temperature-dependent interferon These data time-resolved transcriptome analysis Transcriptome transcriptome analysis transmission efficiencies type I type III interferon upper respiratory epithelium upper respiratory tract Viral viral replication viral replication kinetics virus–host dynamics virus–host interaction dynamics viruses [DOI] 10.1371/journal.pbio.3001158 PMC 바로가기 [Article Type] Research Article
Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model비활성화된 광견병 바이러스 벡터 SARS-CoV-2 백신은 시리아 햄스터 모델에서 질병을 예방합니다Research Article Published on 2021-03-252022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model anticipated Asymptomatic asymptomatic infection asymptomatic infections best caused children coronavirus COVID-19 death develop disease evaluated events generate hamster hamsters highlight Human human disease illness immune response immune responses immunogenic inactivated indicated lung Lung disease Lung pathology Lungs MPLA nasal nasal turbinate nasal turbinates Neutralizing antibodies neutralizing antibody platform Pneumonia pregnant women Prevent prevented rabies Rabies virus Raby reduction in respiratory Respiratory failure robust Safe SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread Transmission trials Vaccine Vaccines vectored vaccine Viral viral replication virus weight loss worldwide pandemic [DOI] 10.1371/journal.ppat.1009383 PMC 바로가기 [Article Type] Research Article
SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, ItalySARS-COV-2 동반이환 네트워크 및 이탈리아 크레마 입원 환자의 결과Research Article Published on 2021-03-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Accuracy ACE ACE inhibitor ACE inhibitors Admission angiotensin angiotensin converting enzyme antagonist C-reactive protein caused Chain Reaction Charlson Comorbidity Index Chest CT chest X-ray Comorbidities Comorbidity Computed tomography correlated correlation Course death Deceased diagnostic Diagnostic accuracy disease distribution drug enzyme Fatality rate Follow-up gold gold standard high mortality homogenous hospital hospitalized patient ICU admission impairment individual inhibitor interstitial pneumonia Italy Laboratory males median age Multiorgan Nasopharyngeal swab negative patients network analysis Non-invasive respiratory support occurred outcome outcomes Patient patients patients older pharmacological treatments polymerase chain reaction positive respiratory Respiratory Support reverse transcriptase SARS-CoV-2 significantly study population survived Swab was performed were recorded [DOI] 10.1371/journal.pone.0248498 PMC 바로가기 [Article Type] Research Article