Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study콜히친으로 치료받은 COVID-19 환자의 사망률 감소: 후향적 관찰 연구 결과Observational Study Published on 2021-03-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 임상, [키워드] 7-point ordinary scale accelerated adjusted adjusted hazard ratio association C-reactive protein Clinical improvement Colchicine colchicine group control group control patient control patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CT scan cumulative mortality diarrhea Hospitalized implicated IMPROVE Inflammatory marker inflammatory markers Inflammatory response linear lymphocyte Lymphocyte count Mortality neutrophil Neutrophil-to-lymphocyte ratio objective occurred outpatients pathway patients Pneumonia Probability proinflammatory pulmonary complications Randomized controlled trial rationale receive reduce reduced Result retrospective retrospective cohort study Retrospective study Side effect skin rashes Support supported survival the patient treated Treatment two groups Weighting [DOI] 10.1371/journal.pone.0248276 PMC 바로가기 [Article Type] Observational Study
Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patientsCOVID-19 환자의 SARS-CoV-2 특이 항체의 혈청 수준에 대한 비만의 영향Research Article Published on 2021-03-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 바이오마커, 진단, [키워드] (C-reactive protein) (nonesterified fatty acids) acute respiratory syndrome amyloid A antibody Blood BMI Body body mass body mass index C-reactive protein chronic systemic inflammation condition Corona coronavirus coronavirus disease COVID-19 COVID-19 obese patient COVID-19 obese patients COVID-19 patient COVID-19 patients CRP evaluated exacerbated expected ferritin help Humoral immunity Hypothesis identify IgG antibodies immune dysfunction Immunity IMPROVE index individual inflammaging Inflammatory inflammatory conditions inflammatory markers Inflammatory response influence marker mass NEFA nonesterified fatty acids obese obese patients obesity Predictive Predictive value pro-inflammatory Protein pulmonary inflammation reduced respiratory Result risk SAA SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG secretion serum amyloid serum amyloid A protein Serum level serum levels Severe Acute Respiratory Syndrome Corona Virus Severe acute respiratory syndrome corona virus-2 shown specific IgG antibodies systemic inflammation [DOI] 10.1371/journal.pone.0245424 PMC 바로가기 [Article Type] Research Article
The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCTAI 지원 흉부 HRCT로 평가한 COVID-19 환자의 폐 섬유증의 특성 및 진화Research Article Published on 2021-03-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] affected albumin bronchiectasis Characteristics Chest chest HRCT Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical discharge Evolution fibrosis Ground-glass opacities High-resolution HRCT IL-6 incidence independent risk factor independent risk factors interlobular septal thickening linear Mild moderate Moderate COVID-19 Most patients Patient patients patients with moderate proportion pulmonary fibrosis pulmonary inflammation resolved reticulation risk factor Risk factors significant difference significant differences significantly significantly higher was used [DOI] 10.1371/journal.pone.0248957 PMC 바로가기 [Article Type] Research Article
DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in miceSARS-CoV-2 스파이크 단백질을 인코딩하는 DNA 백신 후보는 마우스에서 강력한 체액성 및 Th1 세포 매개 면역 반응을 유발했습니다Research Article Published on 2021-03-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS, [키워드] ACE2 Antigen balance binding breadth candidate cell-mediated immune response COVID-19 Critical died DNA vaccine DNA vaccines Effective vaccines elicited expressing followed by full length full-length S geometric mean geometric mean titer geometric mean titers GMTs highest humoral IFN-γ IgG IgG1 IgG2a infection with SARS-CoV-2 inhibit Interaction limit lowest magnitude mice neutralizing antibody pandemic peptide positive cell positive cells PRNT50 PRNT50 titers Protein robust SARS-CoV-2 spike SARS-CoV-2 spike peptide SARS-CoV-2 spike protein sera splenocyte splenocytes Stimulation T cell T cell responses T cells Th1 Vaccine Viral viral RBD wild type [DOI] 10.1371/journal.pone.0248007 PMC 바로가기 [Article Type] Research Article
Immuno-informatics design of a multimeric epitope peptide based vaccine targeting SARS-CoV-2 spike glycoproteinSARS-CoV-2 스파이크 당단백질을 표적으로 하는 다중 에피토프 펩티드 기반 백신의 면역 정보학 설계Research Article Published on 2021-03-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS, [키워드] alleles antibody Antigen antigenic antigenicity approach array B cell epitope B cell epitopes CD4+ T cell CD8+ T cell Cell-mediated immunity characterized chimeric cloned Community COVID-19 Critical Cytokines decrease Developing eight elicit epitope epitope peptide Epitopes expressed fatality homologous IgM and IgG immune immune protection Immuno-informatics in silico increase in information linker mapped MERS MHC I MHC I and II alleles peptide peptide-based vaccine predicted SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein Spike protein T cell Th1 Th2 cytokines the spike protein the vaccine Toll-like receptor translational triggering Vaccine vaccine construct Vaccine design virus [DOI] 10.1371/journal.pone.0248061 PMC 바로가기 [Article Type] Research Article
Higher albumin levels on admission predict better prognosis in patients with confirmed COVID-19입원 시 알부민 수치가 높을수록 COVID-19 확인된 환자의 더 나은 예후 예측Research Article Published on 2021-03-162022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] (coronavirus disease 2019 95% confidence interval acute respiratory distress acute respiratory distress syndrome adjusted adjusted relative risk Admission Admission serum albumin levels adverse event adverse events adverse outcomes albumin albumin level Analysis ARDS Biomarker Biomarkers Chain Reaction Cohort coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients COVID-19 pneumonia COVID-19 testing techniques demographics determine discharge effort evaluate events home oxygen supplementation hospital Hospital mortality Hospitalized Hypoalbuminemia ICU ICU admissions IMPROVE in-hospital complication in-hospital mortality intensive care intensive care unit lead less lower risk multivariate multivariate modified Poisson regression analysis on admission optimization outcome outcomes oxygen Patient patients with COVID-19 PCR performed Pneumonia Poisson regression polymerase chain polymerase chain reaction predict Predictive predictor Prognosis radiologic imaging readmission recorded Relative risk respiratory distress Result risk Screening patient Screening patients serum albumin significantly syndrome Venous Thromboembolism VTE [DOI] 10.1371/journal.pone.0248358 PMC 바로가기 [Article Type] Research Article
Release mechanisms of major DAMPs주요 DAMP의 방출 메커니즘Review Published on 2021-03-132022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] Activation addition anti-DAMP strategies Apoptosis ATP Cancer Cell cell death cell membrane cell-free DNA channel pores contribute Damage-associated molecular patterns DAMP DAMP release DAMP-specific mechanism DAMPs disorder disorders ectosomes effective endogenous molecule endogenous molecules Exocytosis Exosome Exosomes Extracellular extracellular cold-inducible RNA-binding protein extracellular RNA extracellular RNAs Ferroptosis focus foment heat shock proteins Histones Inflammation inflammatory mediator Inflammatory mediators live cell live cells Lysosomes mechanism mechanisms of release mediators membrane rupture molecular pattern necroptosis Necrosis NETosis Other Protein pyroptosis Release released reported secretory lysosome secretory lysosomes Sepsis tissues [DOI] 10.1007/s10495-021-01663-3 PMC 바로가기 [Article Type] Review
Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)COVID-19 치료를 위한 중재: 메타 분석 및 시험 순차 분석이 포함된 살아있는 체계적인 검토의 두 번째 판(The LIVING 프로젝트)Meta-Analysis Published on 2021-03-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 임상, 진단, 치료제, [키워드] 95% CI 95% confidence interval adjusted Admission aggregate data meta-analyses all age group all age groups all-cause mortality Analysis boundary bromhexine caused certainty certainty of evidence Clinical research Clinical significance Cochrane guidelines comparison Comparisons Corticosteroid Corticosteroids COVID-19 database Effect Effects eight events Evidence evidence of Families FIVE Fixed-effect meta-analysis futility GRADE high risk Hydroxychloroquine Immunoglobulin indicate indication indications individual patient data meta-analyses individuals information intensive care Intervention effects intravenous Intravenous immunoglobulin lack life Lopinavir Lopinavir-ritonavir mechanical ventilation meta-analyses Meta-analysis moderate Network meta-analysis no evidence of non-serious adverse non-serious adverse events on mechanical ventilation outcome outcomes participant Participants patient data performed Primary outcomes PRISMA Quality of life random error random errors random-effects meta-analyses randomized clinical trial randomized clinical trials rapidly spreading disease reached reduce reduced Remdesivir renal replacement therapy replacement therapy required Research risk risk of death risk ratio risks of bia Ritonavir searched second secondary Secondary outcomes sequential analysis Serious Adverse Event Serious Adverse Events single trial standard care statistically significant systematic review threshold Tocilizumab Treatment treatment for COVID-19 treatment intervention treatments of COVID-19 Trial Trial methodology trial sequential analyses trial sequential analysis website with COVID-19 [DOI] 10.1371/journal.pone.0248132 PMC 바로가기 [Article Type] Meta-Analysis
Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2ACE2 및 TMPRSS2의 안정적인 발현을 갖는 293T 세포를 사용하여 잘 특성화된 SARS-CoV-2 렌티바이러스 슈도바이러스 중화 분석의 확립Research Article Published on 2021-03-102022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 신약개발, 진단, [키워드] 293T 293T cell ACE2 angiotensin angiotensin converting enzyme assays cell line condition effort enzyme evaluated expressing expression generate Genetic highly pathogenic human angiotensin converting enzyme 2 lentiviral limitations neutralization neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody plasma platform Precision pseudovirus Pseudovirus neutralization assay pseudoviruses reported SARS-CoV-2 SARS-CoV-2 entry scalability sera Serine stability target cells TMPRSS2 transmembrane serine protease transmembrane serine protease 2 variety virus viruses [DOI] 10.1371/journal.pone.0248348 PMC 바로가기 [Article Type] Research Article
Bepridil is potent against SARS-CoV-2 in vitroBepridil은 시험관 내 SARS-CoV-2에 강력합니다.410 Published on 2021-03-092022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis animal model animal models Antiviral bepridil Cell characterized Clinical tests Clinical use Concentration coronavirus COVID-19 COVID-19 patients docking dose-dependent manner drug Drug administration dual ebastine effective endosomal pH food function Host human cell in vitro indicated infected cells inhibit inhibiting interfere Live virus main protease mammalian cell medication Medicine microneutralization pathogen pimozide protease raising respiratory SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus Significance small molecule Small molecules tested Vero E6 [DOI] 10.1073/pnas.2012201118 PMC 바로가기 [Article Type] 410