Biochemistry – Page 9 – Communicable Diseases Research

Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina

아르헨티나에서 SARS-CoV-2 면역 상태, 혈청 유병률 및 회복기 혈장 평가를 위한 긴급 대응

Research Article

Published on 2021-01-142022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, 진단, 치료기술,

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

COVID-19 임상 합병증을 표적으로 하는 SARS-CoV-2 수명 주기, 병태생리학 및 합리화된 치료에 대한 통찰력

Review

Published on 2021-01-122022-08-13
Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, MERS,

[키워드] “cytokine storm” ACE2 activate Adaptive immune response adverse effect adverse effects approach approaches ARDS AT1R clinical complication collateral tissue damage complications of COVID-19 COVID-19 CTSB Cytokine storm distress expression gastrointestinal tract Host human gene hyper-cytokinemia immune responses Infection infection rate infection rates Inflammation inflammatory immune response insight life cycle life-threatening mitigate multi-organ collapse organotropism of SARS-CoV-2 pathobiology of COVID-19 Pathologies pathophysiology Phase 1 Phase 2 Propagation respiratory respiratory and gastrointestinal tract respiratory distress Respiratory distress syndrome robust SARS-CoV-2 SARS-CoV-2 life cycle Sex Signaling Support suppress syndrome systemic failure tissue tissue damage tissues TMPRSS2 Treatment Trigger triggered triggers two-phase disease Viral viral infection virus virus antigen presentation virus transmission
[DOI] 10.1186/s12929-020-00703-5 PMC 바로가기 [Article Type] Review

Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19

심각한 COVID-19 환자를 위한 임상 의사 결정 지원 프로토콜 내에서 염증 조절을 돕는 바이오마커로서의 IP-10의 잠재력에 대한 관찰 코호트 연구

Clinical Trial

Published on 2021-01-122022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Biomarker clinical decision cohort study coronavirus correlated Corticosteroid corticosteroid immunomodulatory therapy COVID-19 patient COVID-19 patients COVID-19-related complications died disease stage disease stages host protein host-pathogen interaction hyperinflammation immune immunoassay immunomodulatory therapy Inflammation intensive care intensive care unit interferon involved IP-10 Lung injury management Mortality Oxygenation Patient performed platform protocol quantitative measurement Registered Regulation respiratory Result severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severely ill COVID-19 patients Severity Score significantly single-center subsequent Support therapeutic utility Viral viral clearance virus-induced hyperinflammation while with COVID-19 γ-induced protein 10
[DOI] 10.1371/journal.pone.0245296 PMC 바로가기 [Article Type] Clinical Trial

Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study

코로나바이러스 질병-2019에 대한 치료용 혈장 교환은 사이토카인 방출 증후군을 유발했습니다. 후향적 성향 일치 대조 연구

Research Article

Published on 2021-01-072022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] 1:1 95% CI Analysis analyzed assigned both groups Cohort Control controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Critical CRS cytokine cytokine release Cytokine release syndrome Cytokines discharge disease severity duration of hospitalization evaluate Forced groups hospital hospitalized patient in both group log rank male males median age moderate Mortality non-randomized objective outcome pathogenic pathophysiology Patient plasma plasma exchange polymerase chain reaction Polymerase chain reaction testing Primary outcome progression PSM reduced Result retrospective secondary Secondary outcomes selected severity significantly standard care Standard of care supportive care survival Symptom syndrome the patient Therapeutic plasma exchange TPE treated Treatment triggered Viral viral clearance was done was used with COVID-19
[DOI] 10.1371/journal.pone.0244853 PMC 바로가기 [Article Type] Research Article

Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China

우한시 및 중국 기타 지역에서 SARS-CoV-2의 혈청형 및 무증상 보균자 현황

Research Article

Published on 2021-01-072022-08-13
Journal: PLoS Neglected Tropical Diseases [Category] Biochemistry, 진단, 치료기술,

The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis

COVID-19 범유행에 대한 만성 신장 질환 및 급성 신장 손상 관련: 체계적인 검토 및 메타 분석

Research Article

Published on 2021-01-052022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19,

[키워드] Acute kidney injury AKI applied Blood urea nitrogen calculated China Chronic kidney disease CKD Complication Continuous renal replacement therapy COVID-19 COVID-19 pandemic COVID-19 patients creatinine Critical CRRT Effect elevated indicated involved kidney Kidney disease mean difference measurement Meta-analysis nitrogen occur Odds ratio Odds ratios outcome Patient renal replacement therapy replacement therapy reported Result review risk serum creatinine severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe group severity of COVID-19 significantly increased SMD Spread susceptible systematic review the SARS-CoV-2 Trial urea
[DOI] 10.1371/journal.pone.0244779 PMC 바로가기 [Article Type] Research Article

Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis

중증 코로나19 환자의 인터루킨-6: 후향적 분석

Clinical Trial

Published on 2020-12-312022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 임상,

[키워드] Admission admitted patients AUROC Blood Blood cells blood concentration C-reactive protein China clinician collected Concentration conducted coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokine storm D-dimers demographic diagnosis of COVID-19 disease evaluate ferritin help highest ICU IL-6 IL-6 level intensive care unit interleukin-6 Interleukine-6 laboratory data Lactate lactate dehydrogenase LDH lymphocyte Lymphocytes Mortality non-survivor outcome parameter pathophysiology Patient patients patients with COVID-19 poor prognosis Predictive Predictive value repeated Result Retrospective analysis Retrospective study risk severity significant difference significantly higher Spread survivor White blood cell White blood cells
[DOI] 10.1371/journal.pone.0244628 PMC 바로가기 [Article Type] Clinical Trial

A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro

새로운 가상 스크리닝 절차는 Pralatrexate를 SARS-CoV-2 RdRp의 억제제로 식별하고 시험관 내 바이러스 복제를 감소시킵니다.

Research Article

Published on 2020-12-312022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative method alternative methods anti-viral drug applied approved drugs Azithromycin conditions coronavirus COVID-19 deep learning demonstrated develop disease drug drug candidates drug candidates targeting Drug screening drugs EC50 value EC50 values effective drug effective drugs FDA-approved drug feasibility global public health hybrid drug identify in vitro inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitors of SARS-CoV-2 inhibitory activity lack leads molecular dynamics Molecular dynamics simulation No effective drug Novel coronavirus paper potential therapeutic agent potential therapeutic agents Pralatrexate provide RdRP reduce Remdesivir Replication respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication screening procedure selected severe acute respiratory syndrome Coronavirus Spread therapeutic agents therapeutic target threat traditional methods treat Vaccine Viral viral replication Viral RNA viral RNA-dependent RNA polymerase Virtual screening virus worldwide crisis
[DOI] 10.1371/journal.pcbi.1008489 PMC 바로가기 [Article Type] Research Article

Optimizing direct RT-LAMP to detect transmissible SARS-CoV-2 from primary nasopharyngeal swab samples

1차 비인두 면봉 샘플에서 전염성 SARS-CoV-2를 검출하기 위해 직접 RT-LAMP 최적화

Research Article

Published on 2020-12-312022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술,

Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave

첫 번째 대유행 물결 이후 스페인 바르셀로나 북부 대도시 지역의 의료 종사자들 사이에서 SARS-CoV-2 IgG 특이적 항체의 혈청 유병률

Research Article

Published on 2020-12-282022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome coronavirus analyzed Anti-S1 anti-SARS-CoV-2 IgG antigens Area assays automated Barcelona caused chemiluminescence collected coronavirus coronavirus 2 COVID-19 diagnosis essential worker General population geographical area global pandemic group Health care Health care system health care systems healthcare healthcare worker Healthcare workers hospital IgG IgG SARS-CoV-2 antibodies IgG SARS-CoV-2 antibody individuals infecting limit of detection management N antigen no significant differences North Outbreaks pandemic participant Patient Patient management positive primary care PROTECT respiratory Result risk S1/S2 Safety measure Safety measures Sample SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 seroprevalence Seroprevalence serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference Spain specific antibody Spread tested
[DOI] 10.1371/journal.pone.0244348 PMC 바로가기 [Article Type] Research Article