Abstract
The prognosis of patients with severe cases of COVID-19 is poor; thus, biomarkers for earlier prediction of COVID-19 progression are vital. We measured levels of five lung injury-related biomarkers, SP-D, KL-6, presepsin, kallistatin and stratifin, in serum samples collected serially during hospitalization from 31 patients with mild/moderate or severe/critical COVID-19 pneumonia, and their predictive performances were compared. Like the previously reported presepsin, a new biomarker candidate, stratifin, was significantly elevated with the onset of severe or critical symptoms in COVID-19 patients and decreased with symptom improvement. Notably, changes in stratifin and presepsin levels were distinctly earlier than those in SP-D, KL-6 and even SpO 2 /FiO 2 values. Furthermore, serum levels of these biomarkers were significantly higher at the pre-severe stage (before the start of oxygen support) of patients who eventually advanced to severe/critical stages than in the patients who remained at the mild/moderate stage. These results were confirmed in an independent cohort, including 71 mild/moderate and 14 severe/critical patients, for whom the performance of stratifin and presepsin in discriminating between mild/moderate and pre-severe conditions of COVID-19 patients was superior to that of the SpO 2 /FiO 2 ratio. Therefore, we concluded that stratifin and presepsin could be used as prognostic biomarkers for severe COVID-19 progression.
Keywords: COVID-19; Predictive biomarker; Presepsin; Stratifin.
【저자키워드】 COVID-19, predictive biomarker, Presepsin, Stratifin., 【초록키워드】 Prognostic biomarkers, COVID-19 pneumonia, Biomarker, Biomarkers, severe COVID-19, Prognosis, Hospitalization, Pneumonia, lung, oxygen, Symptom, progression, Cohort, Patient, severe cases, Critical, patients, prognostic biomarker, COVID-19 patients, COVID-19 patient, Predictive, COVID-19 progression, serum samples, Serum level, serum levels, Stage, Severe case, kallistatin, oxygen support, stratifin, serum sample, FIVE, independent, collected, significantly, reported, the patient, remained, elevated, condition, changes in, Like, significantly higher, prognosis of patient, 【제목키워드】 Biomarker, progression, COVID-19 disease,