Abstract
The coronavirus disease 2019 (COVID-19) pandemic has been associated with high mortality worldwide. Owing to its complicated pathophysiology, diagnostic and prognostic biomarkers for effective patient management remain scarce. We analyzed kynurenine, tryptophan, and serotonin levels in the serum of patients with COVID-19 via liquid chromatography/mass spectrometry analysis. Serum serotonin levels were decreased in patients with more severe COVID-19, along with increased kynurenine and decreased tryptophan concentrations. Patients with moderate disease who subsequently worsened showed significantly lower serotonin concentrations compared with those who did not experience severe disease. Serum serotonin levels may represent a valuable biomarker for COVID-19 severity and prognosis.
【저자키워드】 COVID-19, Biomarker, Prognosis, disease severity, Serotonin, 【초록키워드】 coronavirus disease, pandemic, severe COVID-19, diagnostic, COVID-19 severity, serum, pathophysiology, management, Patient, prognostic biomarker, Concentration, Analysis, severe disease, moderate disease, high mortality, significantly lower, effective, concentrations, analyzed, patients with COVID-19, worsened, 【제목키워드】 Analysis, characterization, severity and prognosis,