In Brief Unexpected serological patterns, such as continuous negative IgM and IgG expression, or exceptionally high titers of IgM were observed in a cohort of 144 COVID-19 patients. To understand the host responses behind the diverse serology, we applied 2-year clinical manifestation and longitudinal serum proteomics analysis. Our findings suggest that COVID-19 patients who do not express antibodies developed cellular immunity for viral defense and that high titers of IgM might not be favorable to COVID-19 recovery.
All Keywords
【저자키워드】 COVID-19, Inflammation, proteomics, serology, COVID-19, Coronavirus disease 2019, cellular immunity, TMT, tandem mass tag, IQR, interquartile range, nAb, Neutralizing Antibody, HDL-C, high-density lipoprotein cholesterol, LDL-C, low-density lipoprotein cholesterol, PCA, principal component analysis, TG, triglyceride, C1, complement 1, CLIA, chemiluminescence immunoassay, DEP, differentially expressed protein, EHR, electronic hospital record, nonVac, nonvaccinated, R1, 1-year follow-up, R2, 2-year follow-up, RT-PCR, reverse-transcriptase polymerase-chain-reaction, Vac, vaccinated,
【저자키워드】 COVID-19, Inflammation, proteomics, serology, COVID-19, Coronavirus disease 2019, cellular immunity, TMT, tandem mass tag, IQR, interquartile range, nAb, Neutralizing Antibody, HDL-C, high-density lipoprotein cholesterol, LDL-C, low-density lipoprotein cholesterol, PCA, principal component analysis, TG, triglyceride, C1, complement 1, CLIA, chemiluminescence immunoassay, DEP, differentially expressed protein, EHR, electronic hospital record, nonVac, nonvaccinated, R1, 1-year follow-up, R2, 2-year follow-up, RT-PCR, reverse-transcriptase polymerase-chain-reaction, Vac, vaccinated,