Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 VaccineSARS-CoV-2에 대한 이전 감염은 비활성화된 COVID-19 백신의 1회 투여 후 증가된 보호 체액 반응과 관련이 있습니다Article Published on 2022-03-022022-09-11 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 humoral antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses assays both viruses CoronaVac COVID-19 COVID-19 vaccine detectable dose elicited ELISA evaluate FIVE Gamma had no immunization inactivated Inactivated vaccine increase in Increased indicated individual induce Lineage lineage B.1 naïve individuals Neutralizing activity neutralizing assays plaque Previous studies previous study PRNT Protective antibody protective antibody response protective antibody responses response retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose sera specific antibodies subject vaccinated individual vaccinated individuals vaccination vaccine dose vaccinees variant were measured [DOI] 10.3390/v14030510 PMC 바로가기 [Article Type] Article
Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19경증 또는 중증 COVID-19 환자와 COVID-19 백신 1차 및 2차 접종 후 항체 반응 비교Comparative Study Published on 2022-03-012022-09-11 Journal: The Korean journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Adult patients analyzed antibody formation Antibody Response Antibody responses blood sample Blood samples BNT162b2 BNT162b2 vaccine ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine collected comparable convalescent patient Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccination COVID-19 vaccine dose enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay first dose healthcare healthcare worker homologous immune response immune responses Immunity Immunoglobulin Immunoglobulin G Infection intervals Mild mRNA vaccination Patient patients SARS-CoV-2 SARS-CoV-2 variant second dose severe COVID-19 single dose Spike protein the antibody response vaccine platform Vaccines [DOI] 10.3904/kjim.2021.409 PMC 바로가기 [Article Type] Comparative Study
An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates아랍에미리트의 투석 환자에서 Sinopharm HB02 COVID19 백신의 항체 반응 및 임상 후유증 분석Article Published on 2022-03-012022-09-11 Journal: Nephrology (Carlton, Vic.) [Category] SARS, 변종, [키워드] adverse events Analysis anti-spike antibodies anti-spike antibody antibodies antibody Antibody Response Antibody responses appear baseline booster dose Case fatality rate Clinical effect Cohort Course COVID COVID-19 COVID-19 vaccination COVID19 dialysis dose examined Fatality rate General population Haemodialysis haemodialysis patients humoral immune response humoral immune responses Humoral response humoral responses immune responses individuals Infection occur Patient patients positive PROTECT reduction in response Side-effects Sinopharm Standard survival the antibody response the vaccine to define United Arab Emirate vaccination vaccination schedule Vaccine were given [DOI] 10.1111/nep.13980 PMC 바로가기 [Article Type] Article
Antibody responses to SARS-CoV-2 nucleocapsid and spike proteins in hospitalized patients with COVID-19: A multicenter, retrospective, cross-sectional study in Japan코로나19로 입원한 환자의 SARS-CoV-2 뉴클레오캡시드 및 스파이크 단백질에 대한 항체 반응: 일본의 다기관, 후향적, 횡단면 연구Multicenter Study Published on 2022-03-012022-09-11 Journal: Respiratory investigation [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] amplification Anti-spike anti-spike protein IgG antibody antibody levels Antibody Response Antibody responses automated collected coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional detect Diagnosis early-stage COVID-19 examined gene amplification healthcare worker hospitalized patient IgG IgM IgM antibodies immune immune responses Immunoglobulin Japan multicenter negative controls peaked plateau Protein retrospective SARS-CoV-2 SARS-CoV-2 nucleocapsid sera Seroconversion Serological assay serological test serology Seropositivity serum sample serum samples significant difference specificity Spike protein statistically significant symptom onset total Ig Validity were used [DOI] 10.1016/j.resinv.2021.11.006 PMC 바로가기 [Article Type] Multicenter Study
Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects기능적 B 세포 결함이 있는 원발성 면역결핍 환자에서 코로나19 메신저 RNA 백신의 면역원성과 내약성Multicenter Study Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 ACE2 blocking antibody ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody deficiency Antibody Response Antibody responses B-cell blocking activity blocking antibody BNT162b2 BNT162b2 vaccine cellular immunity Clinical management cohort of patient common variable immunodeficiency coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccine trials detectable dose effective Efficacy enzyme evaluated functional Good Good syndrome help humoral Humoral response humoral responses IFN-γ IgG antibody IgG responses immune responses immunodeficiency immunogenicity information less mAb Messenger RNA Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 neutralization not effective Patient patients Pfizer-BioNTech PID PIDs positive Primary immunodeficiencies Primary Immunodeficiency RBD RBD binding RBD-specific IgG responses Reactions reactogenicity Receptor binding domain referred to respiratory retrospective retrospective review Safe SARS-CoV-2 SARS-CoV-2 IFN-γ release assay SARS-CoV-2 spike protein SARS-CoV-2 spike protein antibody SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stimulated subject subjects T-cell immune response T-cell Response the spike protein Tolerability vaccination Vaccine was performed were excluded with COVID-19 [DOI] 10.1016/j.jaci.2021.11.022 PMC 바로가기 [Article Type] Multicenter Study
Lack of association between pandemic chilblains and SARS-CoV-2 infection유행성 아동과 SARS-CoV-2 감염 사이의 연관성 부족420 Published on 2022-02-252022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibodies antibody Antibody Response Antibody responses antiviral immune response assays association biopsy causative agent chilblain chilblains Cohort Connecticut coronavirus covid toe diagnose diagnosed Direct Endpoint enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Evidence evidence of First wave immune profiling immunohistochemical staining incidence infections interferon Microarray molecular Most patients pandemic Patient PCR peptide performed pernio positive robust SARS-CoV-2 SARS-COV-2 infection Sequencing seronegative serum severe acute respiratory syndrome Coronavirus Significance staining subsequent Support T cell T cell receptor T cell response T cell responses tissue tissues viral infection were assessed [DOI] 10.1073/pnas.2122090119 PMC 바로가기 [Article Type] 420
SARS-CoV-2 Induces Cytokine Responses in Human BasophilsSARS-CoV-2는 인간 호염기구에서 사이토카인 반응을 유도합니다Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation Alter Antibody Response Antibody responses basophil basophils Caco-2 Caco-2 cells CD107a CD13 CD69 characterized COVID-19 COVID-19 patients cytokine cytokine response degranulation epithelial cell epithelial cells expression help Human IL-13 IL-3 IL-4 immune Immune cell immune cells immune responses increased expression induce Inflammation Interaction marker Orientation pandemic virus PD-L1 promote reducing reported response SARS-CoV-2 SARS-CoV-2 replication surface marker surface markers virus [DOI] 10.3389/fimmu.2022.838448 PMC 바로가기 [Article Type] Article
Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation스푸트니크 백신 접종으로 유도된 기억 B 세포는 생체 외 재자극 시 SARS-CoV-2 중화 항체를 생성합니다Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody Response Antibody responses approach B cell B cell response B.1.351 Beta Cell Cohort complement correlated COVID-19 cross-neutralize dependent on Effect effective vaccine Effective vaccines Ex vivo first dose Health humoral Immunity in-depth analysis induced lentivirus majority MBC MBCs memory B memory B cells memory cell naïve neutralized performed plasma Plasma cell Produce produced recipient response responses robust SARS-CoV-2 SARS-COV-2 infection serological serum antibodies Sputnik V vaccine stimulated subject the vaccine vaccination Vaccine vaccinee variant of SARS-CoV-2 variants of SARS-CoV-2 Wuhan [DOI] 10.3389/fimmu.2022.840707 PMC 바로가기 [Article Type] Article
Implementation and Extended Evaluation of the Euroimmun Anti-SARS-CoV-2 IgG Assay and Its Contribution to the United Kingdom’s COVID-19 Public Health ResponseEuroimmun Anti-SARS-CoV-2 IgG 분석의 구현 및 확장 평가 및 영국의 COVID-19 공중 보건 대응에 대한 기여Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 IgG Antibody responses assay development Characteristics characterization coronavirus correlation COVID-19 Department DHSC Extended IgG immunoassays implementation Laboratory National neutralization Neutralizing antibodies outbreak Pathogens Precision Public Public Health England Research response SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-COV-2 infection security sensitivity serology assays specificity Surveillance tested UK Government United Kingdom [DOI] 10.1128/spectrum.02289-21 PMC 바로가기 [Article Type] Research Article
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patientsSARS-COV-2 입원 및 지역 사회 환자의 내구성 T- 세포 및 체액 반응Clinical Trial Published on 2022-02-222022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] age analyzed antibody Antibody Response Antibody responses assays Blood blood sample Blood samples boost Clinical data clinical observations collected Community Comorbidity determine diagnosed ELISA Gender Hospitalized Humoral response IFN-γ IgA IgG IgM IL-2 immune response Immunity immunosorbent impacted infected patients Infection interferon interferon-γ interleukin investigated long-term memory memory response microneutralization mononuclear cell mononuclear cells neutralization Neutralizing antibodies neutralizing antibody pandemic Patient patients peripheral Peripheral blood Peripheral blood mononuclear cells prospective cohort Protein pseudotype Re-infection recruited response Result risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virus secreting serum sample serum samples severity severity of illness specific antibodies specific antibody T-cell Response T-cell responses vaccination variant variants of concern virus-specific T-cell response virus-specific T-cell responses viruses [DOI] 10.1371/journal.pone.0261979 PMC 바로가기 [Article Type] Clinical Trial